Gene/Proteome Database (LMPD)
LMPD ID
LMP001055
Gene ID
Species
Homo sapiens (Human)
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
Synonyms
AGR16; EDG-5; EDG5; Gpcr13; H218; LPB2; S1P2
Alternate Names
sphingosine 1-phosphate receptor 2; S1P receptor 2; S1P receptor EDG5; S1P receptor Edg-5; sphingosine 1-phosphate receptor Edg-5; endothelial differentiation G-protein coupled receptor 5; endothelial differentiation, sphingolipid G-protein-coupled receptor, 5
Chromosome
19
Map Location
19p13.2
Summary
This gene encodes a member of the G protein-coupled receptors, as well as the EDG family of proteins. This protein participates in sphingosine 1-phosphate-induced cell proliferation, survival, and transcriptional activation [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| sphingosine 1-phosphate receptor 2 | |
|---|---|
| Refseq ID | NP_004221 |
| Protein GI | 134244587 |
| UniProt ID | O95136 |
| mRNA ID | NM_004230 |
| Length | 353 |
| RefSeq Status | VALIDATED |
| MGSLYSEYLNPNKVQEHYNYTKETLETQETTSRQVASAFIVILCCAIVVENLLVLIAVARNSKFHSAMYLFLGNLAASDLLAGVAFVANTLLSGSVTLRLTPVQWFAREGSAFITLSASVFSLLAIAIERHVAIAKVKLYGSDKSCRMLLLIGASWLISLVLGGLPILGWNCLGHLEACSTVLPLYAKHYVLCVVTIFSIILLAIVALYVRIYCVVRSSHADMAAPQTLALLKTVTIVLGVFIVCWLPAFSILLLDYACPVHSCPILYKAHYFFAVSTLNSLLNPVIYTWRSRDLRREVLRPLQCWRPGVGVQGRRRGGTPGHHLLPLRSSSSLERGMHMPTSPTFLEGNTVV | |
Gene Information
Entrez Gene ID
Gene Name
sphingosine-1-phosphate receptor 2
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IDA:UniProtKB | C | plasma membrane |
| GO:0004930 | TAS:ProtInc | F | G-protein coupled receptor activity |
| GO:0001664 | IPI:UniProtKB | F | G-protein coupled receptor binding |
| GO:0005178 | IPI:UniProtKB | F | integrin binding |
| GO:0008289 | TAS:ProtInc | F | lipid binding |
| GO:0038036 | IEA:InterPro | F | sphingosine-1-phosphate receptor activity |
| GO:0007186 | TAS:ProtInc | P | G-protein coupled receptor signaling pathway |
| GO:0000187 | TAS:ProtInc | P | activation of MAPK activity |
| GO:0090394 | IEA:Ensembl | P | negative regulation of excitatory postsynaptic membrane potential |
| GO:0008284 | TAS:ProtInc | P | positive regulation of cell proliferation |
| GO:1903142 | IMP:UniProtKB | P | positive regulation of establishment of endothelial barrier |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_19231 | G alpha (i) signalling events |
| REACT_18365 | Lysosphingolipid and LPA receptors |
Domain Information
UniProt Annotations
Entry Information
Gene Name
sphingosine-1-phosphate receptor 2
Protein Entry
S1PR2_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Function | Receptor for the lysosphingolipid sphingosine 1- phosphate (S1P). S1P is a bioactive lysophospholipid that elicits diverse physiological effect on most types of cells and tissues. When expressed in rat HTC4 hepatoma cells, is capable of mediating S1P-induced cell proliferation and suppression of apoptosis. |
| Similarity | Belongs to the G-protein coupled receptor 1 family. |
| Subcellular Location | Cell membrane; Multi-pass membrane protein. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001055 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 134244587 | RefSeq | NP_004221 | 353 | sphingosine 1-phosphate receptor 2 |
Identical Sequences to LMP001055 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:134244587 | GenBank | AAH69598.1 | 353 | Sphingosine-1-phosphate receptor 2 [Homo sapiens] |
| GI:134244587 | GenBank | AAU98839.1 | 353 | Sequence 23 from patent US 6730663 |
| GI:134244587 | GenBank | EAW84081.1 | 353 | endothelial differentiation, sphingolipid G-protein-coupled receptor, 5, isoform CRA_a [Homo sapiens] |
| GI:134244587 | GenBank | EAW84082.1 | 353 | endothelial differentiation, sphingolipid G-protein-coupled receptor, 5, isoform CRA_a [Homo sapiens] |
| GI:134244587 | GenBank | AIC50320.1 | 353 | S1PR2, partial [synthetic construct] |
| GI:134244587 | RefSeq | XP_006722999.1 | 353 | PREDICTED: sphingosine 1-phosphate receptor 2 isoform X1 [Homo sapiens] |
Related Sequences to LMP001055 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:134244587 | GenBank | AAN99224.1 | 353 | Sequence 4 from patent US 6482609 |
| GI:134244587 | GenBank | AAN99225.1 | 353 | Sequence 5 from patent US 6482609 |
| GI:134244587 | GenBank | AAN99226.1 | 353 | Sequence 6 from patent US 6482609 |
| GI:134244587 | GenBank | AAN99229.1 | 353 | Sequence 12 from patent US 6482609 |
| GI:134244587 | GenBank | AAQ31803.1 | 353 | Sequence 19 from patent US 6566096 |
| GI:134244587 | GenBank | ABH85911.1 | 353 | Sequence 22 from patent US 7052850 |