Gene/Proteome Database (LMPD)
Proteins
| leukotriene A-4 hydrolase isoform 1 | |
|---|---|
| Refseq ID | NP_000886 |
| Protein GI | 4505029 |
| UniProt ID | P09960 |
| mRNA ID | NM_000895 |
| Length | 611 |
| RefSeq Status | VALIDATED |
| MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD | |
| leukotriene A-4 hydrolase isoform 2 | |
|---|---|
| Refseq ID | NP_001243572 |
| Protein GI | 4505029 |
| UniProt ID | P09960 |
| mRNA ID | NM_001256643 |
| Length | 611 |
| RefSeq Status | VALIDATED |
| MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD | |
| leukotriene A-4 hydrolase isoform 3 | |
|---|---|
| Refseq ID | NP_001243573 |
| Protein GI | 4505029 |
| UniProt ID | P09960 |
| mRNA ID | NM_001256644 |
| Length | 611 |
| RefSeq Status | VALIDATED |
| MPEIVDTCSLASPASVCRTKHLHLRCSVDFTRRTLTGTAALTVQSQEDNLRSLVLDTKDLTIEKVVINGQEVKYALGERQSYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKEHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGETPDPEDPSRKIYKFIQKVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSAYEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFNALGGWGELQNSVKTFGETHPFTKLVVDLTDIDPDVAYSSVPYEKGFALLFYLEQLLGGPEIFLGFLKAYVEKFSYKSITTDDWKDFLYSYFKDKVDVLNQVDWNAWLYSPGLPPIKPNYDMTLTNACIALSQRWITAKEDDLNSFNATDLKDLSSHQLNEFLAQTLQRAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEDAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVRTYQEHKASMHPVTAMLVGKDLKVD | |
| YP_003024027 YP_003024034 YP_003024036 | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | IDA:HPA | C | cytoplasm |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0005634 | IDA:HPA | C | nucleus |
| GO:0004177 | IDA:UniProtKB | F | aminopeptidase activity |
| GO:0004301 | IDA:UniProtKB | F | epoxide hydrolase activity |
| GO:0004463 | IDA:UniProtKB | F | leukotriene-A4 hydrolase activity |
| GO:0008237 | IEA:UniProtKB-KW | F | metallopeptidase activity |
| GO:0008233 | TAS:ProtInc | F | peptidase activity |
| GO:0044822 | IDA:UniProtKB | F | poly(A) RNA binding |
| GO:0008270 | IDA:UniProtKB | F | zinc ion binding |
| GO:0019369 | TAS:Reactome | P | arachidonic acid metabolic process |
| GO:0006954 | NAS:ProtInc | P | inflammatory response |
| GO:0019370 | IDA:UniProtKB | P | leukotriene biosynthetic process |
| GO:0006691 | TAS:Reactome | P | leukotriene metabolic process |
| GO:0043171 | IDA:UniProtKB | P | peptide catabolic process |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00590 | Arachidonic acid metabolism |
BIOCYC Pathway Links
| BIOCYC Pathway ID | Description |
|---|---|
| PWY66-375 | leukotriene biosynthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_150420 | Synthesis of Leukotrienes (LT) and Eoxins (EX) |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016024 | Armadillo-type fold |
| IPR012777 | Leukotriene A4 hydrolase |
| IPR001930 | Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase |
| IPR015211 | Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal |
| IPR014782 | Peptidase M1, membrane alanine aminopeptidase, N-terminal |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=L-LTA4; IsoId=P09960-1; Sequence=Displayed; Name=2; Synonyms=S-LTA4; IsoId=P09960-2; Sequence=VSP_041108, VSP_041109; Name=3; IsoId=P09960-3; Sequence=VSP_041107, VSP_041108, VSP_041109; Name=4; IsoId=P09960-4; Sequence=VSP_041107; Note=No experimental confirmation available.; |
| Catalytic Activity | (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate. {ECO |
| Cofactor | Name=Zn(2+); Xref=ChEBI |
| Enzyme Regulation | Inhibited by bestatin. Subject to suicide inhibition by leukotriene A4, due to the formation of a covalent adduct at Tyr-379. |
| Function | Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO |
| Pathway | Lipid metabolism; leukotriene B4 biosynthesis. |
| Ptm | Phosphorylation at Ser-416 inhibits enzymatic activity. |
| Similarity | Belongs to the peptidase M1 family. |
| Subcellular Location | Cytoplasm. |
| Subunit | Monomer. {ECO |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed in monocytes, lymphocytes, neutrophils, reticulocytes, platelets and fibroblasts. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001056 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 4505029 | RefSeq | NP_000886 | 611 | leukotriene A-4 hydrolase isoform 1 |
| 4505029 | RefSeq | NP_001243572 | 611 | leukotriene A-4 hydrolase isoform 2 |
| 4505029 | RefSeq | NP_001243573 | 611 | leukotriene A-4 hydrolase isoform 3 |
Identical Sequences to LMP001056 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505029 | GenBank | JAA38358.1 | 611 | leukotriene A4 hydrolase [Pan troglodytes] |
| GI:4505029 | GenBank | JAA38358.1 | 611 | leukotriene A4 hydrolase [Pan troglodytes] |
| GI:4505029 | GenBank | JAA38358.1 | 611 | leukotriene A4 hydrolase [Pan troglodytes] |
| GI:4505029 | GenBank | AHD74953.1 | 611 | Sequence 15657 from patent US 8586006 |
| GI:4505029 | GenBank | AHD74953.1 | 611 | Sequence 15657 from patent US 8586006 |
| GI:4505029 | GenBank | AHD74953.1 | 611 | Sequence 15657 from patent US 8586006 |
| GI:4505029 | PDB | 4DPR | 611 | Chain A, Structure Of Human Leukotriene A4 Hydrolase In Complex With Inhibitor Captopril |
| GI:4505029 | PDB | 4DPR | 611 | Chain A, Structure Of Human Leukotriene A4 Hydrolase In Complex With Inhibitor Captopril |
| GI:4505029 | PDB | 4DPR | 611 | Chain A, Structure Of Human Leukotriene A4 Hydrolase In Complex With Inhibitor Captopril |
| GI:4505029 | PDB | 4L2L | 611 | Chain A, Human Leukotriene A4 Hydrolase Complexed With Ligand 4-(4- Benzylphenyl)thiazol-2-amine |
| GI:4505029 | PDB | 4L2L | 611 | Chain A, Human Leukotriene A4 Hydrolase Complexed With Ligand 4-(4- Benzylphenyl)thiazol-2-amine |
| GI:4505029 | PDB | 4L2L | 611 | Chain A, Human Leukotriene A4 Hydrolase Complexed With Ligand 4-(4- Benzylphenyl)thiazol-2-amine |
| GI:4505029 | PDB | 4MKT | 611 | Chain A, Human Leukotriene A4 Hydrolase In Complex With Pro-gly-pro Analogue And 4-(4-benzylphenyl)thiazol-2-amine |
| GI:4505029 | PDB | 4MKT | 611 | Chain A, Human Leukotriene A4 Hydrolase In Complex With Pro-gly-pro Analogue And 4-(4-benzylphenyl)thiazol-2-amine |
| GI:4505029 | PDB | 4MKT | 611 | Chain A, Human Leukotriene A4 Hydrolase In Complex With Pro-gly-pro Analogue And 4-(4-benzylphenyl)thiazol-2-amine |
| GI:4505029 | PDB | 4MS6 | 611 | Chain A, Human Leukotriene A4 Hydrolase In Complex With Pro-gly-pro Analogue |
| GI:4505029 | PDB | 4MS6 | 611 | Chain A, Human Leukotriene A4 Hydrolase In Complex With Pro-gly-pro Analogue |
| GI:4505029 | PDB | 4MS6 | 611 | Chain A, Human Leukotriene A4 Hydrolase In Complex With Pro-gly-pro Analogue |
Related Sequences to LMP001056 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:4505029 | DBBJ | BAK63698.1 | 611 | leukotriene A-4 hydrolase [Pan troglodytes] |
| GI:4505029 | DBBJ | BAK63698.1 | 611 | leukotriene A-4 hydrolase [Pan troglodytes] |
| GI:4505029 | DBBJ | BAK63698.1 | 611 | leukotriene A-4 hydrolase [Pan troglodytes] |
| GI:4505029 | PDB | 1H19 | 611 | Chain A, Structure Of [e271q] Leukotriene A4 Hydrolase |
| GI:4505029 | PDB | 1H19 | 611 | Chain A, Structure Of [e271q] Leukotriene A4 Hydrolase |
| GI:4505029 | PDB | 1H19 | 611 | Chain A, Structure Of [e271q] Leukotriene A4 Hydrolase |
| GI:4505029 | PDB | 3CHP | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With (3s)-3-Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl) Amino]butanoic Acid |
| GI:4505029 | PDB | 3CHP | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With (3s)-3-Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl) Amino]butanoic Acid |
| GI:4505029 | PDB | 3CHP | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With (3s)-3-Amino-4-Oxo-4-[(4-Phenylmethoxyphenyl) Amino]butanoic Acid |
| GI:4505029 | PDB | 3CHQ | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With N5-[4-(Phenylmethoxy)phenyl]-L-Glutamine |
| GI:4505029 | PDB | 3CHQ | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With N5-[4-(Phenylmethoxy)phenyl]-L-Glutamine |
| GI:4505029 | PDB | 3CHQ | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With N5-[4-(Phenylmethoxy)phenyl]-L-Glutamine |
| GI:4505029 | PDB | 3CHR | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With 4-Amino-N-[4-(Phenylmethoxy)phenyl]-Butanamide |
| GI:4505029 | PDB | 3CHR | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With 4-Amino-N-[4-(Phenylmethoxy)phenyl]-Butanamide |
| GI:4505029 | PDB | 3CHR | 610 | Chain A, Crystal Structure Of Leukotriene A4 Hydrolase In Complex With 4-Amino-N-[4-(Phenylmethoxy)phenyl]-Butanamide |
| GI:4505029 | RefSeq | NP_001267011.1 | 611 | leukotriene A-4 hydrolase [Pan troglodytes] |
| GI:4505029 | RefSeq | NP_001267011.1 | 611 | leukotriene A-4 hydrolase [Pan troglodytes] |
| GI:4505029 | RefSeq | NP_001267011.1 | 611 | leukotriene A-4 hydrolase [Pan troglodytes] |