Gene/Proteome Database (LMPD)

LMPD ID
LMP001063
Gene ID
13074
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 17, subfamily a, polypeptide 1
Gene Symbol
Cyp17a1
Synonyms
Cyp17; p450c17
Alternate Names
steroid 17-alpha-hydroxylase/17,20 lyase; CYPXVII; cytochrome P450c17; cytochrome P450, 17; cytochrome P450-C17; cytochrome P450 17A1; cytochrome P450, 17a1; steroid 17-alpha hydroxylase; 17-alpha-hydroxyprogesterone aldolase
Chromosome
19
Map Location
19 C3|19 38.97 cM
EC Number
1.14.99.9

Proteins

steroid 17-alpha-hydroxylase/17,20 lyase precursor
Refseq ID NP_031835
Protein GI 160948601
UniProt ID P27786
mRNA ID NM_007809
Length 507
RefSeq Status VALIDATED
MWELVGLLLLILAYFFWPKSKTPNAKFPRSLPFLPLVGSLPFLPRRGHMHANFFKLQEKYGPIYSLRLGTTTAVIVGHYQLAREVLVKKGKEFSGRPQMVTLGLLSDQGKGVAFADSSSSWQLHRKLVFSTFSLFRDDQKLEKMICQEANSLCDLILTYDGESRDLSTLIFKSVINIICTICFNISFENKDPILTTIQTFTEGIVDVLGHSDLVDIFPWLKIFPNKNLEMIKEHTKIREKTLVEMFEKCKEKFNSESLSSLTDILIQAKMNAENNNTGEGQDPSVFSDKHILVTVGDIFGAGIETTSSVLNWILAFLVHNPEVKRKIQKEIDQYVGFSRTPSFNDRTHLLMLEATIREVLRIRPVAPLLIPHKANIDSSIGEFAIPKDTHVIINLWALHHDKNEWDQPDRFMPERFLDPTGSHLITPTPSYLPFGAGPRSCIGEALARQELFIFMALLLQRFDFDVSDDKQLPCLVGDPKVVFLIDPFKVKITVRQAWKDAQVEVST
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2225 peptide sequence: MWELVGLLLLILAYFFWP

Gene Information

Entrez Gene ID
13074
Gene Name
cytochrome P450, family 17, subfamily a, polypeptide 1
Gene Symbol
Cyp17a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0030424 IDA:MGI C axon
GO:0005783 IEA:Ensembl C endoplasmic reticulum
GO:0016020 IEA:UniProtKB-KW C membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0043025 IDA:MGI C neuronal cell body
GO:0047442 IEA:UniProtKB-EC F 17-alpha-hydroxyprogesterone aldolase activity
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004508 IDA:MGI F steroid 17-alpha-monooxygenase activity
GO:0030325 IEA:Ensembl P adrenal gland development
GO:0018879 IEA:Ensembl P biphenyl metabolic process
GO:0071236 IEA:Ensembl P cellular response to antibiotic
GO:0071371 IEA:Ensembl P cellular response to gonadotropin stimulus
GO:0071222 IEA:Ensembl P cellular response to lipopolysaccharide
GO:0018894 IEA:Ensembl P dibenzo-p-dioxin metabolic process
GO:0006704 IDA:MGI P glucocorticoid biosynthetic process
GO:0021766 IEA:Ensembl P hippocampus development
GO:0042446 ISS:UniProtKB P hormone biosynthetic process
GO:0033327 IEA:Ensembl P Leydig cell differentiation
GO:0030728 IEA:Ensembl P ovulation
GO:0018958 IEA:Ensembl P phenol-containing compound metabolic process
GO:0018963 IEA:Ensembl P phthalate metabolic process
GO:0090031 IEA:Ensembl P positive regulation of steroid hormone biosynthetic process
GO:0042448 ISS:UniProtKB P progesterone metabolic process
GO:0010034 IEA:Ensembl P response to acetate
GO:0051591 IEA:Ensembl P response to cAMP
GO:0034097 IEA:Ensembl P response to cytokine
GO:0042493 IEA:Ensembl P response to drug
GO:0060992 IEA:Ensembl P response to fungicide
GO:0009635 IEA:Ensembl P response to herbicide
GO:0017085 IEA:Ensembl P response to insecticide
GO:0010212 IEA:Ensembl P response to ionizing radiation
GO:0051597 IEA:Ensembl P response to methylmercury
GO:0031667 IEA:Ensembl P response to nutrient levels
GO:0032526 IEA:Ensembl P response to retinoic acid
GO:0048545 IEA:Ensembl P response to steroid hormone
GO:0008202 ISS:UniProtKB P steroid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04913 Ovarian steroidogenesis
mmu04917 Prolactin signaling pathway
mmu00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR017972 Cytochrome P450, conserved site
IPR002401 Cytochrome P450, E-class, group I

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 17, subfamily a, polypeptide 1
Protein Entry
CP17A_MOUSE
UniProt ID
P27786
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 17-alpha-hydroxyprogesterone = androst-4-ene- 3,17-dione + acetaldehyde.
Catalytic Activity A C(21)-steroid + (reduced NADPH--hemoprotein reductase) + O(2) = a 17-alpha-hydroxy-C(21)-steroid + (oxidized NADPH--hemoprotein reductase) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Enzyme Regulation Regulated predominantly by intracellular cAMP levels.
Function Conversion of pregnenolone and progesterone to their 17- alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction. Involved in sexual development during fetal life and at puberty.
Pathway Lipid metabolism; steroid biosynthesis.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Membrane {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001063 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
160948601 RefSeq NP_031835 507 steroid 17-alpha-hydroxylase/17,20 lyase precursor

Identical Sequences to LMP001063 proteins

Reference Database Accession Length Protein Name
GI:160948601 GenBank AAA39877.1 507 cytochrome P-450 17-alpha-hydroxylse/C17-20 lyase [Mus musculus]
GI:160948601 GenBank AAT01928.1 507 cytochrome P450 17-alpha hydroxylase/17,20 lyase [Mus musculus]
GI:160948601 GenBank EDL42014.1 507 cytochrome P450, family 17, subfamily a, polypeptide 1 [Mus musculus]
GI:160948601 SwissProt P27786.1 507 RecName: Full=Steroid 17-alpha-hydroxylase/17,20 lyase; AltName: Full=17-alpha-hydroxyprogesterone aldolase; AltName: Full=CYPXVII; AltName: Full=Cytochrome P450 17A1; AltName: Full=Cytochrome P450-C17; Short=Cytochrome P450c17 [Mus musculus]

Related Sequences to LMP001063 proteins

Reference Database Accession Length Protein Name
GI:160948601 DBBJ BAE22120.1 507 unnamed protein product [Mus musculus]
GI:160948601 GenBank AAH64793.1 507 Cytochrome P450, family 17, subfamily a, polypeptide 1 [Mus musculus]
GI:160948601 GenBank AAH78898.1 507 Cytochrome P450, family 17, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:160948601 GenBank EDL94359.1 507 cytochrome P450, family 17, subfamily a, polypeptide 1 [Rattus norvegicus]
GI:160948601 RefSeq XP_006231496.1 507 PREDICTED: steroid 17-alpha-hydroxylase/17,20 lyase isoform X1 [Rattus norvegicus]
GI:160948601 RefSeq XP_006231497.1 507 PREDICTED: steroid 17-alpha-hydroxylase/17,20 lyase isoform X1 [Rattus norvegicus]