Gene/Proteome Database (LMPD)

LMPD ID
LMP001078
Gene ID
8443
Species
Homo sapiens (Human)
Gene Name
glyceronephosphate O-acyltransferase
Gene Symbol
GNPAT
Synonyms
DAP-AT; DAPAT; DHAPAT
Alternate Names
dihydroxyacetone phosphate acyltransferase; DHAP-AT; glycerone-phosphate O-acyltransferase; acyl-CoA:dihydroxyacetonephosphateacyltransferase
Chromosome
1
Map Location
1q42
EC Number
2.3.1.42
Summary
This gene encodes an enzyme located in the peroxisomal membrane which is essential to the synthesis of ether phospholipids. Mutations in this gene are associated with rhizomelic chondrodysplasia punctata. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for GNPAT

Proteins

dihydroxyacetone phosphate acyltransferase
Refseq ID NP_055051
Protein GI 7657134
UniProt ID O15228
mRNA ID NM_014236
Length 680
RefSeq Status REVIEWED
MESSSSSNSYFSVGPTSPSAVVLLYSKELKKWDEFEDILEERRHVSDLKFAMKCYTPLVYKGITPCKPIDIKCSVLNSEEIHYVIKQLSKESLQSVDVLREEVSEILDEMSHKLRLGAIRFCAFTLSKVFKQIFSKVCVNEEGIQKLQRAIQEHPVVLLPSHRSYIDFLMLSFLLYNYDLPVPVIAAGMDFLGMKMVGELLRMSGAFFMRRTFGGNKLYWAVFSEYVKTMLRNGYAPVEFFLEGTRSRSAKTLTPKFGLLNIVMEPFFKREVFDTYLVPISISYDKILEETLYVYELLGVPKPKESTTGLLKARKILSENFGSIHVYFGDPVSLRSLAAGRMSRSSYNLVPRYIPQKQSEDMHAFVTEVAYKMELLQIENMVLSPWTLIVAVLLQNRPSMDFDALVEKTLWLKGLTQAFGGFLIWPDNKPAEEVVPASILLHSNIASLVKDQVILKVDSGDSEVVDGLMLQHITLLMCSAYRNQLLNIFVRPSLVAVALQMTPGFRKEDVYSCFRFLRDVFADEFIFLPGNTLKDFEEGCYLLCKSEAIQVTTKDILVTEKGNTVLEFLVGLFKPFVESYQIICKYLLSEEEDHFSEEQYLAAVRKFTSQLLDQGTSQCYDVLSSDVQKNALAACVRLGVVEKKKINNNCIFNVNEPATTKLEEMLGCKTPIGKPATAKL

Gene Information

Entrez Gene ID
8443
Gene Name
glyceronephosphate O-acyltransferase
Gene Symbol
GNPAT
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IDA:UniProtKB C membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005782 TAS:Reactome C peroxisomal matrix
GO:0005778 IDA:UniProtKB C peroxisomal membrane
GO:0005777 IDA:UniProtKB C peroxisome
GO:0016287 IDA:UniProtKB F glycerone-phosphate O-acyltransferase activity
GO:0016290 IDA:UniProtKB F palmitoyl-CoA hydrolase activity
GO:0005102 IPI:UniProtKB F receptor binding
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0021587 IEA:Ensembl P cerebellum morphogenesis
GO:0008611 IDA:UniProtKB P ether lipid biosynthetic process
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0061024 IEA:Ensembl P membrane organization
GO:0030913 IEA:Ensembl P paranodal junction assembly
GO:0006654 TAS:Reactome P phosphatidic acid biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0042493 IEA:Ensembl P response to drug
GO:0070542 IEA:Ensembl P response to fatty acid
GO:0007584 IEA:Ensembl P response to nutrient
GO:0042594 IEA:Ensembl P response to starvation
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007416 IEA:Ensembl P synapse assembly

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism
hsa04146 Peroxisome

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_1407 Plasmalogen biosynthesis
REACT_120906 Synthesis of PA

Domain Information

InterPro Annotations

Accession Description
IPR028353 Dihydroxyacetone phosphate acyltransferase
IPR022284 Glycerol-3-phosphate O-acyltransferase/Dihydroxyacetone phosphate acyltransferase
IPR002123 Phospholipid/glycerol acyltransferase

UniProt Annotations

Entry Information

Gene Name
glyceronephosphate O-acyltransferase
Protein Entry
GNPAT_HUMAN
UniProt ID
O15228
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15228-1; Sequence=Displayed; Name=2; IsoId=O15228-2; Sequence=VSP_056435; Note=No experimental confirmation available.;
Catalytic Activity Acyl-CoA + glycerone phosphate = CoA + acylglycerone phosphate.
Disease Rhizomelic chondrodysplasia punctata 2 (RCDP2) [MIM
Domain The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate.
Pathway Membrane lipid metabolism; glycerophospholipid metabolism.
Similarity Belongs to the GPAT/DAPAT family.
Subcellular Location Peroxisome membrane ; Peripheral membrane protein ; Matrix side . Note=Exclusively localized to the lumenal side of the peroxisomal membrane.
Subunit May be part of a heterotrimeric complex composed of DAP- AT, ADAP-S and a modified form of DAP-AT.

Identical and Related Proteins

Unique RefSeq proteins for LMP001078 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7657134 RefSeq NP_055051 680 dihydroxyacetone phosphate acyltransferase

Identical Sequences to LMP001078 proteins

Reference Database Accession Length Protein Name
GI:7657134 GenBank AAG17547.1 680 dihydroxyacetonephosphate acyltransferase [Homo sapiens]
GI:7657134 GenBank EAW69953.1 680 glyceronephosphate O-acyltransferase [Homo sapiens]
GI:7657134 GenBank AEF64182.1 680 Sequence 217 from patent US 7932032
GI:7657134 GenBank AFN90284.1 680 Sequence 217 from patent US 8198025
GI:7657134 GenBank AHD70843.1 680 Sequence 4311 from patent US 8586006
GI:7657134 SwissProt O15228.1 680 RecName: Full=Dihydroxyacetone phosphate acyltransferase; Short=DAP-AT; Short=DHAP-AT; AltName: Full=Acyl-CoA:dihydroxyacetonephosphateacyltransferase; AltName: Full=Glycerone-phosphate O-acyltransferase [Homo sapiens]

Related Sequences to LMP001078 proteins

Reference Database Accession Length Protein Name
GI:7657134 DBBJ BAD93119.1 693 glyceronephosphate O-acyltransferase variant, partial [Homo sapiens]
GI:7657134 DBBJ BAD96493.1 680 glyceronephosphate O-acyltransferase variant, partial [Homo sapiens]
GI:7657134 DBBJ BAD97024.1 680 glyceronephosphate O-acyltransferase variant, partial [Homo sapiens]
GI:7657134 GenBank AAH00450.1 680 Glyceronephosphate O-acyltransferase [Homo sapiens]
GI:7657134 GenBank JAA09109.1 680 glyceronephosphate O-acyltransferase [Pan troglodytes]
GI:7657134 GenBank JAA13278.1 680 glyceronephosphate O-acyltransferase [Pan troglodytes]