Gene/Proteome Database (LMPD)

LMPD ID
LMP001079
Gene ID
51102
Species
Homo sapiens (Human)
Gene Name
mitochondrial trans-2-enoyl-CoA reductase
Gene Symbol
MECR
Synonyms
CGI-63; FASN2B; NRBF1
Alternate Names
trans-2-enoyl-CoA reductase, mitochondrial; nuclear receptor binding factor 1; mitochondrial 2-enoyl thioester reductase; homolog of yeast 2-enoyl thioester reductase
Chromosome
1
Map Location
1p35.3
EC Number
1.3.1.38

Proteins

trans-2-enoyl-CoA reductase, mitochondrial isoform a
Refseq ID NP_057095
Protein GI 544346134
UniProt ID Q9BV79
mRNA ID NM_016011
Length 373
RefSeq Status VALIDATED
MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGDPAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGLLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM
transit_peptide: 1..53 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (Potential); propagated from UniProtKB/Swiss-Prot (Q9BV79.2) calculated_mol_wt: 5778 peptide sequence: MWVCSTLWRVRTPARQWRGLLPASGCHGPAASSYSASAEPARVRALVYGHHGD mat_peptide: 54..373 product: Trans-2-enoyl-CoA reductase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q9BV79.2) calculated_mol_wt: 34668 peptide sequence: PAKVVELKNLELAAVRGSDVRVKMLAAPINPSDINMIQGNYGLLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM
trans-2-enoyl-CoA reductase, mitochondrial isoform b
Refseq ID NP_001019903
Protein GI 544346114
UniProt ID Q9BV79
mRNA ID NM_001024732
Length 297
RefSeq Status VALIDATED
MLAAPINPSDINMIQGNYGLLPELPAVGGNEGVAQVVAVGSNVTGLKPGDWVIPANAGLGTWRTEAVFSEEALIQVPSDIPLQSAATLGVNPCTAYRMLMDFEQLQPGDSVIQNASNSGVGQAVIQIAAALGLRTINVVRDRPDIQKLSDRLKSLGAEHVITEEELRRPEMKNFFKDMPQPRLALNCVGGKSSTELLRQLARGGTMVTYGGMAKQPVVASVSLLIFKDLKLRGFWLSQWKKDHSPDQFKELILTLCDLIRRGQLTAPACSQVPLQDYQSALEASMKPFISSKQILTM

Gene Information

Entrez Gene ID
51102
Gene Name
mitochondrial trans-2-enoyl-CoA reductase
Gene Symbol
MECR
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:UniProtKB C mitochondrion
GO:0019166 IDA:UniProtKB F trans-2-enoyl-CoA reductase (NADPH) activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process
GO:0006631 IDA:UniProtKB P fatty acid metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00062 Fatty acid elongation
hsa01212 Fatty acid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR013154 Alcohol dehydrogenase GroES-like
IPR002085 Alcohol dehydrogenase superfamily, zinc-type
IPR013149 Alcohol dehydrogenase, C-terminal
IPR011032 GroES (chaperonin 10)-like
IPR016040 NAD(P)-binding domain

UniProt Annotations

Entry Information

Gene Name
mitochondrial trans-2-enoyl-CoA reductase
Protein Entry
MECR_HUMAN
UniProt ID
Q9BV79
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV79-1; Sequence=Displayed; Name=2; IsoId=Q9BV79-2; Sequence=VSP_041131; Note=No experimental confirmation available.;
Biophysicochemical Properties Kinetic parameters: KM=37 uM for trans-2-hexenoyl-CoA {ECO
Catalytic Activity Acyl-CoA + NADP(+) = trans-2,3-dehydroacyl-CoA + NADPH. {ECO
Function Oxidoreductase with a preference for short and medium chain substrates, including trans-2-hexenoyl-CoA (C6), trans-2- decenoyl-CoA (C10), and trans-2-hexadecenoyl-CoA (C16). May play a role in mitochondrial fatty acid synthesis.
Sequence Caution Sequence=AAD34058.1; Type=Frameshift; Positions=14, 19; Evidence= ;
Similarity Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.
Subcellular Location Mitochondrion .
Subunit Homodimer. {ECO
Tissue Specificity Highly expressed in skeletal and heart muscle. Expressed at lower level in placenta, liver, kidney and pancreas. Weakly or not expressed in lung.

Identical and Related Proteins

Unique RefSeq proteins for LMP001079 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
544346134 RefSeq NP_057095 373 trans-2-enoyl-CoA reductase, mitochondrial isoform a
544346114 RefSeq NP_001019903 297 trans-2-enoyl-CoA reductase, mitochondrial isoform b

Identical Sequences to LMP001079 proteins

Reference Database Accession Length Protein Name
GI:544346114 DBBJ BAG52984.1 297 unnamed protein product [Homo sapiens]
GI:544346134 DBBJ BAI46777.1 373 mitochondrial trans-2-enoyl-CoA reductase, partial [synthetic construct]
GI:544346134 GenBank AAH01419.1 373 Mitochondrial trans-2-enoyl-CoA reductase [Homo sapiens]
GI:544346134 GenBank EAX07654.1 373 mitochondrial trans-2-enoyl-CoA reductase, isoform CRA_b [Homo sapiens]
GI:544346114 GenBank EAX07655.1 297 mitochondrial trans-2-enoyl-CoA reductase, isoform CRA_c [Homo sapiens]
GI:544346134 GenBank ADZ15732.1 373 mitochondrial trans-2-enoyl-CoA reductase, partial [synthetic construct]
GI:544346134 GenBank AIC56381.1 373 MECR, partial [synthetic construct]

Related Sequences to LMP001079 proteins

Reference Database Accession Length Protein Name
GI:544346114 DBBJ BAI46777.1 373 mitochondrial trans-2-enoyl-CoA reductase, partial [synthetic construct]
GI:544346134 EMBL CAG32984.1 373 CGI-63 [Homo sapiens]
GI:544346114 GenBank AAD34058.1 373 CGI-63 protein [Homo sapiens]
GI:544346114 GenBank AAH01419.1 373 Mitochondrial trans-2-enoyl-CoA reductase [Homo sapiens]
GI:544346114 GenBank ADZ15732.1 373 mitochondrial trans-2-enoyl-CoA reductase, partial [synthetic construct]
GI:544346134 GenBank EHH49700.1 373 hypothetical protein EGM_00407 [Macaca fascicularis]
GI:544346114 GenBank AIC56381.1 373 MECR, partial [synthetic construct]
GI:544346134 RefSeq XP_001156115.1 373 PREDICTED: trans-2-enoyl-CoA reductase, mitochondrial isoform X2 [Pan troglodytes]
GI:544346134 RefSeq XP_003828155.1 373 PREDICTED: trans-2-enoyl-CoA reductase, mitochondrial isoform X1 [Pan paniscus]
GI:544346134 RefSeq XP_004025368.1 373 PREDICTED: trans-2-enoyl-CoA reductase, mitochondrial isoform 1 [Gorilla gorilla gorilla]
GI:544346114 RefSeq NP_057095.3 373 trans-2-enoyl-CoA reductase, mitochondrial isoform a [Homo sapiens]
GI:544346134 SwissProt Q9BV79.2 373 RecName: Full=Trans-2-enoyl-CoA reductase, mitochondrial; AltName: Full=Nuclear receptor-binding factor 1; Short=HsNrbf-1; Short=NRBF-1; Flags: Precursor [Homo sapiens]