Gene/Proteome Database (LMPD)

LMPD ID
LMP001082
Gene ID
18783
Species
Mus musculus (Mouse)
Gene Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene Symbol
Pla2g4a
Synonyms
Pla2g4; cPLA2; cPLA2alpha
Alternate Names
cytosolic phospholipase A2; cPLA2-alpha; Type IV PLA2; cytosolic PLA2; phospholipase A2, group 4; phospholipase A2 group IVA; Cytosolic phospholipase A2 (CPLA2)
Chromosome
1
Map Location
1 G1|1 63.51 cM
EC Number
3.1.1.4

Proteins

cytosolic phospholipase A2
Refseq ID NP_032895
Protein GI 6679369
UniProt ID P47713
mRNA ID NM_008869
Length 748
RefSeq Status PROVISIONAL
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGTFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFPVSSMKVGEKKEVPFIFNQVTEMILEMSLEVCSCPDLRFSMALCDQEKTFRQQRKENIKENMKKLLGPKKSEGLYSTRDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYIAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIQNRMSMTLSSLKEKVNAARCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQNKGSTMEEELENITAKHIVSNDSSDSDDEAQGPKGTENEEAEKEYQSDNQASWVHRMLMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLRDFSSQDSFDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDTSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDVEKDCPTIIHFVLANINFRKYKAPGVLRETKEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMYFNTLNNIDVIKDAIVESIEYRRQNPSRCSVSLSNVEARKFFNKEFLSKPTV

Gene Information

Entrez Gene ID
18783
Gene Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Gene Symbol
Pla2g4a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:MGI C Golgi apparatus
GO:0031410 IEA:UniProtKB-KW C cytoplasmic vesicle
GO:0005829 IDA:UniProtKB C cytosol
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0005509 ISS:UniProtKB F calcium ion binding
GO:0047498 IEA:Ensembl F calcium-dependent phospholipase A2 activity
GO:0005544 ISS:UniProtKB F calcium-dependent phospholipid binding
GO:0004622 IEA:UniProtKB-EC F lysophospholipase activity
GO:0004623 IDA:UniProtKB F phospholipase A2 activity
GO:0050482 IDA:UniProtKB P arachidonic acid secretion
GO:0071236 IDA:MGI P cellular response to antibiotic
GO:0046456 IMP:MGI P icosanoid biosynthetic process
GO:0009395 IEA:InterPro P phospholipid catabolic process
GO:0042127 IGI:MGI P regulation of cell proliferation

KEGG Pathway Links

KEGG Pathway ID Description
mmu04750 Inflammatory mediator regulation of TRP channels
mmu04921 Oxytocin signaling pathway
mmu04611 Platelet activation
mmu04014 Ras signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR016035 Acyl transferase/acyl hydrolase/lysophospholipase
IPR000008 C2 domain
IPR002642 Lysophospholipase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)
Protein Entry
PA24A_MOUSE
UniProt ID
P47713
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 2-lysophosphatidylcholine + H(2)O = glycerophosphocholine + a carboxylate.
Catalytic Activity Phosphatidylcholine + H(2)O = 1- acylglycerophosphocholine + a carboxylate.
Domain The N-terminal C2 domain associates with lipid membranes upon calcium binding. It modulates enzyme activity by presenting the active site to its substrate in response to elevations of cytosolic Ca(2+) (By similarity). {ECO:0000250}.
Enzyme Regulation Stimulated by agonists such as ATP, EGF, thrombin and bradykinin as well as by cytosolic Ca(2+).
Function Selectively hydrolyzes arachidonyl phospholipids in the sn-2 position releasing arachidonic acid. Together with its lysophospholipid activity, it is implicated in the initiation of the inflammatory response.
Ptm Activated by phosphorylation at both Ser-505 and Ser-726. {ECO:0000269|PubMed:10978317, ECO:0000269|PubMed:19144319}.
Similarity Contains 1 C2 domain. {ECO:0000255|PROSITE- ProRule:PRU00041}.
Similarity Contains 1 PLA2c domain. {ECO:0000255|PROSITE- ProRule:PRU00555}.
Subcellular Location Cytoplasm. Cytoplasmic vesicle. Note=Translocates to membrane vesicles in a calcium-dependent fashion.

Identical and Related Proteins

Unique RefSeq proteins for LMP001082 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6679369 RefSeq NP_032895 748 cytosolic phospholipase A2

Identical Sequences to LMP001082 proteins

Reference Database Accession Length Protein Name
GI:6679369 DBBJ BAE26047.1 748 unnamed protein product [Mus musculus]
GI:6679369 EMBL CAF06393.1 748 unnamed protein product [Mus musculus]
GI:6679369 GenBank AAH03816.1 748 Phospholipase A2, group IVA (cytosolic, calcium-dependent) [Mus musculus]
GI:6679369 GenBank EDL39489.1 748 phospholipase A2, group IVA (cytosolic, calcium-dependent) [Mus musculus]
GI:6679369 GenBank AEU43261.1 748 Sequence 10 from patent US 8052970
GI:6679369 GenBank AEU43320.1 748 Sequence 69 from patent US 8052970

Related Sequences to LMP001082 proteins

Reference Database Accession Length Protein Name
GI:6679369 GenBank AAH70940.1 752 Phospholipase A2, group IVA (cytosolic, calcium-dependent) [Rattus norvegicus]
GI:6679369 GenBank EDM09590.1 752 phospholipase A2, group IVA (cytosolic, calcium-dependent) [Rattus norvegicus]
GI:6679369 GenBank AEU43258.1 752 Sequence 7 from patent US 8052970
GI:6679369 GenBank AEU43310.1 752 Sequence 59 from patent US 8052970
GI:6679369 RefSeq NP_598235.2 752 cytosolic phospholipase A2 [Rattus norvegicus]
GI:6679369 SwissProt P50393.1 752 RecName: Full=Cytosolic phospholipase A2; Short=cPLA2; AltName: Full=Phospholipase A2 group IVA; Includes: RecName: Full=Phospholipase A2; AltName: Full=Phosphatidylcholine 2-acylhydrolase; Includes: RecName: Full=Lysophospholipase [Rattus norvegicus]