Gene/Proteome Database (LMPD)

LMPD ID
LMP001083
Gene ID
6258
Species
Homo sapiens (Human)
Gene Name
retinoid X receptor, gamma
Gene Symbol
RXRG
Synonyms
NR2B3; RXRC
Chromosome
1
Map Location
1q22-q23
Summary
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Orthologs
View orthologs and multiple alignments for RXRG

Proteins

retinoic acid receptor RXR-gamma isoform a
Refseq ID NP_008848
Protein GI 5902068
UniProt ID P48443
mRNA ID NM_006917
Length 463
RefSeq Status REVIEWED
MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
retinoic acid receptor RXR-gamma isoform c
Refseq ID NP_001243499
Protein GI 375151577
UniProt ID F1T097
mRNA ID NM_001256570
Length 340
RefSeq Status REVIEWED
MNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT
retinoic acid receptor RXR-gamma isoform c
Refseq ID NP_001243500
Protein GI 375151581
UniProt ID P48443
mRNA ID NM_001256571
Length 340
RefSeq Status REVIEWED
Protein sequence is identical to GI:375151577 (mRNA isoform)

Gene Information

Entrez Gene ID
6258
Gene Name
retinoid X receptor, gamma
Gene Symbol
RXRG
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005654 TAS:Reactome C nucleoplasm
GO:0004886 TAS:ProtInc F 9-cis retinoic acid receptor activity
GO:0043565 IEA:Ensembl F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0010467 TAS:Reactome P gene expression
GO:0007507 IEA:Ensembl P heart development
GO:0030182 IEA:Ensembl P neuron differentiation
GO:0007422 IEA:Ensembl P peripheral nervous system development
GO:0045944 IEA:Ensembl P positive regulation of transcription from RNA polymerase II promoter
GO:0031641 IEA:Ensembl P regulation of myelination
GO:0032526 IEA:Ensembl P response to retinoic acid
GO:0007519 IEA:Ensembl P skeletal muscle tissue development
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter

KEGG Pathway Links

KEGG Pathway ID Description
hsa04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR021780 Nuclear/hormone receptor activator site AF-1
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor, gamma
Protein Entry
RXRG_HUMAN
UniProt ID
P48443
Species
Human

Comments

Comment Type Description
Domain Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity).
Interaction P10276:RARA; NbExp=3; IntAct=EBI-712405, EBI-413374;
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus {ECO
Subunit Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer.

Identical and Related Proteins

Unique RefSeq proteins for LMP001083 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
5902068 RefSeq NP_008848 463 retinoic acid receptor RXR-gamma isoform a
375151577 RefSeq NP_001243499 340 retinoic acid receptor RXR-gamma isoform c

Identical Sequences to LMP001083 proteins

Reference Database Accession Length Protein Name
GI:5902068 DBBJ BAJ83970.1 463 retinoic acid receptor RXR-gamma [Homo sapiens]
GI:5902068 GenBank ADZ17356.1 463 retinoid X nuclear receptor gamma variant 1 [Homo sapiens]
GI:5902068 GenBank AEN39531.1 463 Sequence 16 from patent US 7998986
GI:5902068 GenBank AEP73963.1 463 Sequence 22 from patent US 8013001
GI:5902068 GenBank AIC49662.1 463 RXRG, partial [synthetic construct]
GI:375151577 RefSeq NP_001243500.1 340 retinoic acid receptor RXR-gamma isoform c [Homo sapiens]
GI:5902068 RefSeq XP_003824630.1 463 PREDICTED: retinoic acid receptor RXR-gamma isoform X1 [Pan paniscus]
GI:375151577 RefSeq XP_003949681.1 340 PREDICTED: retinoic acid receptor RXR-gamma isoform X2 [Pan troglodytes]
GI:375151577 RefSeq XP_008976501.1 340 PREDICTED: retinoic acid receptor RXR-gamma isoform X2 [Pan paniscus]

Related Sequences to LMP001083 proteins

Reference Database Accession Length Protein Name
GI:375151577 DBBJ BAI45951.1 463 retinoid X receptor, gamma, partial [synthetic construct]
GI:375151577 GenBank AAH12063.1 463 Retinoid X receptor, gamma [Homo sapiens]
GI:375151577 GenBank ACE86731.1 463 retinoid X receptor, gamma protein, partial [synthetic construct]
GI:375151577 GenBank ACE87417.1 463 retinoid X receptor, gamma protein [synthetic construct]
GI:5902068 GenBank ACM81994.1 466 Sequence 7492 from patent US 6812339
GI:375151577 GenBank ACN04139.1 463 Sequence 22 from patent US 7482366
GI:375151577 RefSeq NP_008848.1 463 retinoic acid receptor RXR-gamma isoform a [Homo sapiens]
GI:5902068 RefSeq NP_001124824.1 463 retinoic acid receptor RXR-gamma [Pongo abelii]
GI:5902068 RefSeq XP_003893537.1 463 PREDICTED: retinoic acid receptor RXR-gamma isoform X1 [Papio anubis]
GI:5902068 RefSeq XP_007987890.1 463 PREDICTED: retinoic acid receptor RXR-gamma [Chlorocebus sabaeus]
GI:5902068 RefSeq XP_010371665.1 463 PREDICTED: retinoic acid receptor RXR-gamma isoform X1 [Rhinopithecus roxellana]
GI:5902068 SwissProt Q5REL6.1 463 RecName: Full=Retinoic acid receptor RXR-gamma; AltName: Full=Nuclear receptor subfamily 2 group B member 3; AltName: Full=Retinoid X receptor gamma [Pongo abelii]