Gene/Proteome Database (LMPD)
LMPD ID
LMP001083
Gene ID
Species
Homo sapiens (Human)
Gene Name
retinoid X receptor, gamma
Gene Symbol
Synonyms
NR2B3; RXRC
Chromosome
1
Map Location
1q22-q23
Summary
This gene encodes a member of the retinoid X receptor (RXR) family of nuclear receptors which are involved in mediating the antiproliferative effects of retinoic acid (RA). This receptor forms dimers with the retinoic acid, thyroid hormone, and vitamin D receptors, increasing both DNA binding and transcriptional function on their respective response elements. This gene is expressed at significantly lower levels in non-small cell lung cancer cells. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jun 2010]
Orthologs
Proteins
| retinoic acid receptor RXR-gamma isoform a | |
|---|---|
| Refseq ID | NP_008848 |
| Protein GI | 5902068 |
| UniProt ID | P48443 |
| mRNA ID | NM_006917 |
| Length | 463 |
| RefSeq Status | REVIEWED |
| MYGNYSHFMKFPAGYGGSPGHTGSTSMSPSAALSTGKPMDSHPSYTDTPVSAPRTLSAVGTPLNALGSPYRVITSAMGPPSGALAAPPGINLVAPPSSQLNVVNSVSSSEDIKPLPGLPGIGNMNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT | |
| retinoic acid receptor RXR-gamma isoform c | |
|---|---|
| Refseq ID | NP_001243499 |
| Protein GI | 375151577 |
| UniProt ID | F1T097 |
| mRNA ID | NM_001256570 |
| Length | 340 |
| RefSeq Status | REVIEWED |
| MNYPSTSPGSLVKHICAICGDRSSGKHYGVYSCEGCKGFFKRTIRKDLIYTCRDNKDCLIDKRQRNRCQYCRYQKCLVMGMKREAVQEERQRSRERAESEAECATSGHEDMPVERILEAELAVEPKTESYGDMNMENSTNDPVTNICHAADKQLFTLVEWAKRIPHFSDLTLEDQVILLRAGWNELLIASFSHRSVSVQDGILLATGLHVHRSSAHSAGVGSIFDRVLTELVSKMKDMQMDKSELGCLRAIVLFNPDAKGLSNPSEVETLREKVYATLEAYTKQKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLETPLQIT | |
| retinoic acid receptor RXR-gamma isoform c | |
|---|---|
| Refseq ID | NP_001243500 |
| Protein GI | 375151581 |
| UniProt ID | P48443 |
| mRNA ID | NM_001256571 |
| Length | 340 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:375151577 (mRNA isoform) | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005654 | TAS:Reactome | C | nucleoplasm |
| GO:0004886 | TAS:ProtInc | F | 9-cis retinoic acid receptor activity |
| GO:0043565 | IEA:Ensembl | F | sequence-specific DNA binding |
| GO:0003707 | IEA:InterPro | F | steroid hormone receptor activity |
| GO:0008270 | IEA:InterPro | F | zinc ion binding |
| GO:0010467 | TAS:Reactome | P | gene expression |
| GO:0007507 | IEA:Ensembl | P | heart development |
| GO:0030182 | IEA:Ensembl | P | neuron differentiation |
| GO:0007422 | IEA:Ensembl | P | peripheral nervous system development |
| GO:0045944 | IEA:Ensembl | P | positive regulation of transcription from RNA polymerase II promoter |
| GO:0031641 | IEA:Ensembl | P | regulation of myelination |
| GO:0032526 | IEA:Ensembl | P | response to retinoic acid |
| GO:0007519 | IEA:Ensembl | P | skeletal muscle tissue development |
| GO:0006367 | TAS:Reactome | P | transcription initiation from RNA polymerase II promoter |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04919 | Thyroid hormone signaling pathway |
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR008946 | Nuclear hormone receptor, ligand-binding |
| IPR000536 | Nuclear hormone receptor, ligand-binding, core |
| IPR021780 | Nuclear/hormone receptor activator site AF-1 |
| IPR000003 | Retinoid X receptor/HNF4 |
| IPR001723 | Steroid hormone receptor |
| IPR013088 | Zinc finger, NHR/GATA-type |
| IPR001628 | Zinc finger, nuclear hormone receptor-type |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Domain | Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain. |
| Function | Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid (By similarity). |
| Interaction | P10276:RARA; NbExp=3; IntAct=EBI-712405, EBI-413374; |
| Similarity | Belongs to the nuclear hormone receptor family. NR2 subfamily. |
| Similarity | Contains 1 nuclear receptor DNA-binding domain. |
| Subcellular Location | Nucleus {ECO |
| Subunit | Homodimer. Heterodimer with a RAR molecule. Binds DNA preferentially as a RAR/RXR heterodimer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001083 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 5902068 | RefSeq | NP_008848 | 463 | retinoic acid receptor RXR-gamma isoform a |
| 375151577 | RefSeq | NP_001243499 | 340 | retinoic acid receptor RXR-gamma isoform c |
Identical Sequences to LMP001083 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:5902068 | DBBJ | BAJ83970.1 | 463 | retinoic acid receptor RXR-gamma [Homo sapiens] |
| GI:5902068 | GenBank | ADZ17356.1 | 463 | retinoid X nuclear receptor gamma variant 1 [Homo sapiens] |
| GI:5902068 | GenBank | AEN39531.1 | 463 | Sequence 16 from patent US 7998986 |
| GI:5902068 | GenBank | AEP73963.1 | 463 | Sequence 22 from patent US 8013001 |
| GI:5902068 | GenBank | AIC49662.1 | 463 | RXRG, partial [synthetic construct] |
| GI:375151577 | RefSeq | NP_001243500.1 | 340 | retinoic acid receptor RXR-gamma isoform c [Homo sapiens] |
| GI:5902068 | RefSeq | XP_003824630.1 | 463 | PREDICTED: retinoic acid receptor RXR-gamma isoform X1 [Pan paniscus] |
| GI:375151577 | RefSeq | XP_003949681.1 | 340 | PREDICTED: retinoic acid receptor RXR-gamma isoform X2 [Pan troglodytes] |
| GI:375151577 | RefSeq | XP_008976501.1 | 340 | PREDICTED: retinoic acid receptor RXR-gamma isoform X2 [Pan paniscus] |
Related Sequences to LMP001083 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:375151577 | DBBJ | BAI45951.1 | 463 | retinoid X receptor, gamma, partial [synthetic construct] |
| GI:375151577 | GenBank | AAH12063.1 | 463 | Retinoid X receptor, gamma [Homo sapiens] |
| GI:375151577 | GenBank | ACE86731.1 | 463 | retinoid X receptor, gamma protein, partial [synthetic construct] |
| GI:375151577 | GenBank | ACE87417.1 | 463 | retinoid X receptor, gamma protein [synthetic construct] |
| GI:5902068 | GenBank | ACM81994.1 | 466 | Sequence 7492 from patent US 6812339 |
| GI:375151577 | GenBank | ACN04139.1 | 463 | Sequence 22 from patent US 7482366 |
| GI:375151577 | RefSeq | NP_008848.1 | 463 | retinoic acid receptor RXR-gamma isoform a [Homo sapiens] |
| GI:5902068 | RefSeq | NP_001124824.1 | 463 | retinoic acid receptor RXR-gamma [Pongo abelii] |
| GI:5902068 | RefSeq | XP_003893537.1 | 463 | PREDICTED: retinoic acid receptor RXR-gamma isoform X1 [Papio anubis] |
| GI:5902068 | RefSeq | XP_007987890.1 | 463 | PREDICTED: retinoic acid receptor RXR-gamma [Chlorocebus sabaeus] |
| GI:5902068 | RefSeq | XP_010371665.1 | 463 | PREDICTED: retinoic acid receptor RXR-gamma isoform X1 [Rhinopithecus roxellana] |
| GI:5902068 | SwissProt | Q5REL6.1 | 463 | RecName: Full=Retinoic acid receptor RXR-gamma; AltName: Full=Nuclear receptor subfamily 2 group B member 3; AltName: Full=Retinoid X receptor gamma [Pongo abelii] |