Gene/Proteome Database (LMPD)

LMPD ID
LMP001096
Gene ID
3292
Species
Homo sapiens (Human)
Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Gene Symbol
HSD17B1
Synonyms
EDH17B2; EDHB17; HSD17; SDR28C1
Alternate Names
estradiol 17-beta-dehydrogenase 1; E2DH; 20-alpha-HSD; 17-beta-HSD 1; estradiol 17-beta-dehydrogenase-1; 20 alpha-hydroxysteroid dehydrogenase; 17-beta-hydroxysteroid dehydrogenase type 1; placental 17-beta-hydroxysteroid dehydrogenase; hydroxysteroid (17-beta) dehydrogenase 1 isoform; short chain dehydrogenase/reductase family 28CE, member 1
Chromosome
17
Map Location
17q11-q21
EC Number
1.1.1.62

Proteins

estradiol 17-beta-dehydrogenase 1
Refseq ID NP_000404
Protein GI 223718074
UniProt ID P14061
mRNA ID NM_000413
Length 328
RefSeq Status VALIDATED
MARTVVLITGCSSGIGLHLAVRLASDPSQSFKVYATLRDLKTQGRLWEAARALACPPGSLETLQLDVRDSKSVAAARERVTEGRVDVLVCNAGLGLLGPLEALGEDAVASVLDVNVVGTVRMLQAFLPDMKRRGSGRVLVTGSVGGLMGLPFNDVYCASKFALEGLCESLAVLLLPFGVHLSLIECGPVHTAFMEKVLGSPEEVLDRTDIHTFHRFYQYLAHSKQVFREAAQNPEEVAEVFLTALRAPKPTLRYFTTERFLPLLRMRLDDPSGSNYVTAMHREVFGDVPAKAEAGAEAGGGAGPGAEDEAGRGAVGDPELGDPPAAPQ

Gene Information

Entrez Gene ID
3292
Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Gene Symbol
HSD17B1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0031965 IDA:HPA C nuclear membrane
GO:0005634 IDA:HPA C nucleus
GO:0003824 TAS:ProtInc F catalytic activity
GO:0004303 TAS:Reactome F estradiol 17-beta-dehydrogenase activity
GO:0060348 IEA:Ensembl P bone development
GO:0071248 IEA:Ensembl P cellular response to metal ion
GO:0006703 TAS:Reactome P estrogen biosynthetic process
GO:0008210 TAS:ProtInc P estrogen metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006694 TAS:ProtInc P steroid biosynthetic process
GO:0008202 TAS:Reactome P steroid metabolic process
GO:0061370 IEA:Ensembl P testosterone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04913 Ovarian steroidogenesis
ko04913 Ovarian steroidogenesis
hsa00140 Steroid hormone biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR011348 17beta-dehydrogenase
IPR002347 Glucose/ribitol dehydrogenase
IPR016040 NAD(P)-binding domain
IPR002198 Short-chain dehydrogenase/reductase SDR
IPR020904 Short-chain dehydrogenase/reductase, conserved site

UniProt Annotations

Entry Information

Gene Name
hydroxysteroid (17-beta) dehydrogenase 1
Protein Entry
DHB1_HUMAN
UniProt ID
P14061
Species
Human

Comments

Comment Type Description
Catalytic Activity 17-beta-estradiol + NAD(P)(+) = estrone + NAD(P)H.
Function Favors the reduction of estrogens and androgens. Also has 20-alpha-HSD activity. Uses preferentially NADH.
Pathway Steroid biosynthesis; estrogen biosynthesis.
Similarity Belongs to the short-chain dehydrogenases/reductases (SDR) family.
Subcellular Location Cytoplasm.
Subunit Homodimer.
Web Resource Name=SHMPD; Note=The Singapore human mutation and polymorphism database; URL="http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=HSD17B1";

Identical and Related Proteins

Unique RefSeq proteins for LMP001096 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
223718074 RefSeq NP_000404 328 estradiol 17-beta-dehydrogenase 1

Identical Sequences to LMP001096 proteins

Reference Database Accession Length Protein Name
GI:223718074 SwissProt P14061.3 328 RecName: Full=Estradiol 17-beta-dehydrogenase 1; AltName: Full=17-beta-hydroxysteroid dehydrogenase type 1; Short=17-beta-HSD 1; AltName: Full=20 alpha-hydroxysteroid dehydrogenase; Short=20-alpha-HSD; AltName: Full=E2DH; AltName: Full=Placental 17-beta-hydroxysteroid dehydrogenase [Homo sapiens]

Related Sequences to LMP001096 proteins

Reference Database Accession Length Protein Name
GI:223718074 DBBJ BAG54583.1 328 unnamed protein product [Homo sapiens]
GI:223718074 EMBL CAA31792.1 328 unnamed protein product [Homo sapiens]
GI:223718074 GenBank AAI04753.1 328 Hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapiens]
GI:223718074 GenBank AAI11936.1 328 Hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapiens]
GI:223718074 GenBank EAW60836.1 328 hydroxysteroid (17-beta) dehydrogenase 1 [Homo sapiens]
GI:223718074 GenBank AIC54581.1 328 HSD17B1, partial [synthetic construct]