Gene/Proteome Database (LMPD)

LMPD ID
LMP001097
Gene ID
5330
Species
Homo sapiens (Human)
Gene Name
phospholipase C, beta 2
Gene Symbol
PLCB2
Synonyms
PLC-beta-2
Alternate Names
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; phosphoinositide phospholipase C-beta-2
Chromosome
15
Map Location
15q15
EC Number
3.1.4.11

Proteins

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1
Refseq ID NP_004564
Protein GI 95147333
UniProt ID Q00722
mRNA ID NM_004573
Length 1185
RefSeq Status VALIDATED
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 2
Refseq ID NP_001271226
Protein GI 546231595
UniProt ID Q00722
mRNA ID NM_001284297
Length 1181
RefSeq Status VALIDATED
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 3
Refseq ID NP_001271227
Protein GI 546232005
UniProt ID Q00722
mRNA ID NM_001284298
Length 1170
RefSeq Status VALIDATED
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKNDAINPEDFPEPVYKSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAGEGTVWAGEEGTELEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRSYVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVISGQFLSERSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVFEKILMPELASLRVAVMEEGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFIFLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVASQVNGALAPTSNGSPEPRTASLEELRELKGVVKLQRRHEKELRELERRGARRWEELLQRGAAQLAELGPPGVGGVGACKLGPGKGSRKKRSLPREESAGAAPGEGPEGVDGRVRELKDRLELELLRQGEEQYECVLKRKEQHVAEQISKMMELAREKQAAELKALKETSENDTKEMKKKLETKRLERIQGMTKVTTDKMAQERLKREINNSHIQEVVQVIKQMTENLERHQEKLEEKQAACLEQIREMEKQFQKEALAEYEARMKGLEAEVKESVRACLRTCFPSEAKDKPERACECPPELCEQDPLIAKADAQESRL
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 4
Refseq ID NP_001271228
Protein GI 546231499
UniProt ID Q9BVT6
mRNA ID NM_001284299
Length 199
RefSeq Status VALIDATED
MSLLNPVLLPPKVKAYLSQGERFIKWDDETTVASPVILRVDPKGYYLYWTYQSKEMEFLDITSIRDTRFGKFAKMPKSQKLRDVFNMDFPDNSFLLKTLTVVSGPDMVDLTFHNFVSYKENVGKAWAEDVLALVKHPLTANASRSTFLDKILVKLKMQLNSEGKIPVKNFFQMFPADRKRVEAALSACHLPKGKPGGAR

Gene Information

Entrez Gene ID
5330
Gene Name
phospholipase C, beta 2
Gene Symbol
PLCB2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005509 IEA:InterPro F calcium ion binding
GO:0004435 TAS:ProtInc F phosphatidylinositol phospholipase C activity
GO:0004629 TAS:ProtInc F phospholipase C activity
GO:0004871 IEA:UniProtKB-KW F signal transducer activity
GO:0007202 TAS:ProtInc P activation of phospholipase C activity
GO:0043647 TAS:Reactome P inositol phosphate metabolic process
GO:0035556 IEA:InterPro P intracellular signal transduction
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006644 TAS:ProtInc P phospholipid metabolic process
GO:0050913 IEA:Ensembl P sensory perception of bitter taste
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0007268 TAS:Reactome P synaptic transmission

KEGG Pathway Links

KEGG Pathway ID Description
hsa04750 Inflammatory mediator regulation of TRP channels
hsa04921 Oxytocin signaling pathway
hsa04611 Platelet activation
hsa04022 cGMP-PKG signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR028403 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2
IPR000008 C2 domain
IPR011992 EF-hand domain pair
IPR014815 PLC-beta, C-terminal
IPR017946 PLC-like phosphodiesterase, TIM beta/alpha-barrel domain
IPR016280 Phosphatidylinositol-4, 5-bisphosphate phosphodiesterase beta
IPR001192 Phosphoinositide phospholipase C family
IPR000909 Phospholipase C, phosphatidylinositol-specific , X domain
IPR001711 Phospholipase C, phosphatidylinositol-specific, Y domain
IPR015359 Phospholipase C, phosphoinositol-specific, EF-hand-like

UniProt Annotations

Entry Information

Gene Name
phospholipase C, beta 2
Protein Entry
Q9BVT6_HUMAN
UniProt ID
Q9BVT6
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q00722-1; Sequence=Displayed; Name=2; IsoId=Q00722-2; Sequence=VSP_035770; Name=3; IsoId=Q00722-3; Sequence=VSP_054490; Note=No experimental confirmation available.;
Catalytic Activity 1-phosphatidyl-1D-myo-inositol 4,5- bisphosphate + H(2)O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.
Cofactor Name=Ca(2+); Xref=ChEBI
Function The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes.
Miscellaneous The receptor-mediated activation of PLC-beta-2 is most effectively mediated by one G-protein alpha subunit, alpha- 16.
Similarity Contains 1 C2 domain. {ECO
Similarity Contains 1 PI-PLC X-box domain. {ECO
Similarity Contains 1 PI-PLC Y-box domain. {ECO
Subunit Interacts with RAC1.
Web Resource Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL="http://atlasgeneticsoncology.org/Genes/PLCB2ID41743ch15q15.html";

Identical and Related Proteins

Unique RefSeq proteins for LMP001097 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
95147333 RefSeq NP_004564 1185 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1
546231595 RefSeq NP_001271226 1181 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 2
546232005 RefSeq NP_001271227 1170 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 3
546231499 RefSeq NP_001271228 199 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 4

Identical Sequences to LMP001097 proteins

Reference Database Accession Length Protein Name
GI:546231595 EMBL CBF62882.1 1181 unnamed protein product [Homo sapiens]
GI:546231595 EMBL CBU87758.1 1181 unnamed protein product [Homo sapiens]
GI:546231595 EMBL CBU96705.1 1181 unnamed protein product [Homo sapiens]
GI:546231499 GenBank AAH00939.1 199 PLCB2 protein [Homo sapiens]
GI:546231499 GenBank AAH09009.1 199 PLCB2 protein [Homo sapiens]
GI:546231499 GenBank AAP35551.1 199 phospholipase C, beta 2 [Homo sapiens]
GI:546231499 GenBank EAW92402.1 199 phospholipase C, beta 2, isoform CRA_a [Homo sapiens]
GI:546232005 GenBank AAI36468.1 1170 PLCB2 protein [Homo sapiens]
GI:546231595 GenBank AED62135.1 1181 Sequence 17 from patent US 7902154
GI:546231595 GenBank AGX54693.1 1181 Sequence 9742 from patent US 8541208
GI:546231595 GenBank AGX64133.1 1181 Sequence 28376 from patent US 8541208
GI:95147333 SwissProt Q00722.2 1185 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; AltName: Full=Phosphoinositide phospholipase C-beta-2; AltName: Full=Phospholipase C-beta-2; Short=PLC-beta-2 [Homo sapiens]

Related Sequences to LMP001097 proteins

Reference Database Accession Length Protein Name
GI:546231499 EMBL CBF74549.1 1181 unnamed protein product [Homo sapiens]
GI:95147333 EMBL CBF74549.1 1181 unnamed protein product [Homo sapiens]
GI:95147333 EMBL CBF62882.1 1181 unnamed protein product [Homo sapiens]
GI:546231499 EMBL CBF62882.1 1181 unnamed protein product [Homo sapiens]
GI:546231499 GenBank AAP36256.1 200 Homo sapiens phospholipase C, beta 2, partial [synthetic construct]
GI:546231595 GenBank ACM84946.1 1212 Sequence 10444 from patent US 6812339
GI:546231595 RefSeq NP_004564.2 1185 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform 1 [Homo sapiens]
GI:95147333 RefSeq XP_003826613.1 1185 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X2 [Pan paniscus]
GI:546232005 RefSeq XP_003900814.1 1170 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [Papio anubis]
GI:546231595 RefSeq XP_006720634.1 1184 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7 [Homo sapiens]
GI:95147333 RefSeq XP_006720634.1 1184 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7 [Homo sapiens]
GI:546232005 RefSeq XP_006720634.1 1184 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7 [Homo sapiens]
GI:546232005 RefSeq XP_008015237.1 1170 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [Chlorocebus sabaeus]
GI:546231499 RefSeq XP_009003816.1 199 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X7 [Callithrix jacchus]
GI:546231499 RefSeq XP_008950212.1 199 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X1 [Pan paniscus]
GI:546232005 RefSeq XP_008950214.1 1181 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3 [Pan paniscus]
GI:546231595 RefSeq XP_008950214.1 1181 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3 [Pan paniscus]
GI:95147333 RefSeq XP_009427075.1 1185 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X3 [Pan troglodytes]
GI:95147333 RefSeq XP_009427076.1 1184 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [Pan troglodytes]
GI:546232005 RefSeq XP_009427076.1 1184 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X4 [Pan troglodytes]
GI:546231499 RefSeq XP_009427083.1 199 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X10 [Pan troglodytes]
GI:546232005 RefSeq XP_009427084.1 1181 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X11 [Pan troglodytes]
GI:546231595 RefSeq XP_009427084.1 1181 PREDICTED: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2 isoform X11 [Pan troglodytes]
GI:546231595 SwissProt Q00722.2 1185 RecName: Full=1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-2; AltName: Full=Phosphoinositide phospholipase C-beta-2; AltName: Full=Phospholipase C-beta-2; Short=PLC-beta-2 [Homo sapiens]