Gene/Proteome Database (LMPD)

LMPD ID
LMP001112
Gene ID
223
Species
Homo sapiens (Human)
Gene Name
aldehyde dehydrogenase 9 family, member A1
Gene Symbol
ALDH9A1
Synonyms
ALDH4; ALDH7; ALDH9; E3; TMABADH
Chromosome
1
Map Location
1q23.1
Summary
This protein belongs to the aldehyde dehydrogenase family of proteins. It has a high activity for oxidation of gamma-aminobutyraldehyde and other amino aldehydes. The enzyme catalyzes the dehydrogenation of gamma-aminobutyraldehyde to gamma-aminobutyric acid (GABA). This isozyme is a tetramer of identical 54-kD subunits. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ALDH9A1

Proteins

4-trimethylaminobutyraldehyde dehydrogenase
Refseq ID NP_000687
Protein GI 115387104
UniProt ID P49189
mRNA ID NM_000696
Length 518
RefSeq Status REVIEWED
MFLRAGLAALSPLLRSLRPSPVAAMSTGTFVVSQPLNYRGGARVEPADASGTEKAFEPATGRVIATFTCSGEKEVNLAVQNAKAAFKIWSQKSGMERCRILLEAARIIREREDEIATMECINNGKSIFEARLDIDISWQCLEYYAGLAASMAGEHIQLPGGSFGYTRREPLGVCVGIGAWNYPFQIASWKSAPALACGNAMVFKPSPFTPVSALLLAEIYSEAGVPPGLFNVVQGGAATGQFLCQHPDVAKVSFTGSVPTGMKIMEMSAKGIKPVTLELGGKSPLIIFSDCDMNNAVKGALMANFLTQGQVCCNGTRVFVQKEILDKFTEEVVKQTQRIKIGDPLLEDTRMGPLINRPHLERVLGFVKVAKEQGAKVLCGGDIYVPEDPKLKDGYYMRPCVLTNCRDDMTCVKEEIFGPVMSILSFDTEAEVLERANDTTFGLAAGVFTRDIQRAHRVVAELQAGTCFINNYNVSPVELPFGGYKKSGFGRENGRVTIEYYSQLKTVCVEMGDVESAF

Gene Information

Entrez Gene ID
223
Gene Name
aldehyde dehydrogenase 9 family, member A1
Gene Symbol
ALDH9A1
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 IEA:Ensembl C cytosol
GO:0005739 IEA:Ensembl C mitochondrion
GO:0047105 IEA:Ensembl F 4-trimethylammoniobutyraldehyde dehydrogenase activity
GO:0051287 IEA:Ensembl F NAD binding
GO:0043176 IEA:Ensembl F amine binding
GO:0019145 IEA:Ensembl F aminobutyraldehyde dehydrogenase activity
GO:0009437 IEA:Ensembl P carnitine metabolic process
GO:0001822 IEA:Ensembl P kidney development
GO:0001889 IEA:Ensembl P liver development

KEGG Pathway Links

KEGG Pathway ID Description
hsa00010 Glycolysis / Gluconeogenesis

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-6100 L-carnitine biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_2125 Carnitine synthesis

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 9 family, member A1
Protein Entry
AL9A1_HUMAN
UniProt ID
P49189
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001112 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
115387104 RefSeq NP_000687 518 4-trimethylaminobutyraldehyde dehydrogenase

Identical Sequences to LMP001112 proteins

Reference Database Accession Length Protein Name
GI:115387104 GenBank EAW90758.1 518 aldehyde dehydrogenase 9 family, member A1 [Homo sapiens]
GI:115387104 GenBank AAI51141.1 518 Aldehyde dehydrogenase 9 family, member A1 [Homo sapiens]
GI:115387104 GenBank AAI51142.1 518 Aldehyde dehydrogenase 9 family, member A1 [Homo sapiens]
GI:115387104 GenBank ACW21199.1 518 Sequence 90 from patent US 7560233
GI:115387104 GenBank ADA20145.1 518 Sequence 1969 from patent US 7608413
GI:115387104 GenBank AEN36041.1 518 Sequence 1969 from patent US 7998689

Related Sequences to LMP001112 proteins

Reference Database Accession Length Protein Name
GI:115387104 GenBank ACM82007.1 553 Sequence 7505 from patent US 6812339
GI:115387104 GenBank JAA03811.1 518 aldehyde dehydrogenase 9 family, member A1 [Pan troglodytes]
GI:115387104 GenBank JAA11483.1 518 aldehyde dehydrogenase 9 family, member A1 [Pan troglodytes]
GI:115387104 GenBank JAA25291.1 518 aldehyde dehydrogenase 9 family, member A1 [Pan troglodytes]
GI:115387104 RefSeq NP_001126165.1 518 4-trimethylaminobutyraldehyde dehydrogenase [Pongo abelii]
GI:115387104 RefSeq XP_008976503.1 518 PREDICTED: LOW QUALITY PROTEIN: 4-trimethylaminobutyraldehyde dehydrogenase [Pan paniscus]