Gene/Proteome Database (LMPD)

LMPD ID
LMP001121
Gene ID
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase long-chain family member 6
Gene Symbol
Synonyms
ACS2; FACL6; LACS 6; LACS2; LACS5
Chromosome
5
Map Location
5q31.1
EC Number
6.2.1.3
Summary
The protein encoded by this gene catalyzes the formation of acyl-CoA from fatty acids, ATP, and CoA, using magnesium as a cofactor. The encoded protein plays a major role in fatty acid metabolism in the brain. Translocations with the ETV6 gene are causes of myelodysplastic syndrome with basophilia, acute myelogenous leukemia with eosinophilia, and acute eosinophilic leukemia. Several transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2011]
Orthologs

Proteins

long-chain-fatty-acid--CoA ligase 6 isoform a
Refseq ID NP_056071
Protein GI 327412323
UniProt ID Q9UKU0
mRNA ID NM_015256
Length 697
RefSeq Status REVIEWED
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
long-chain-fatty-acid--CoA ligase 6 isoform b
Refseq ID NP_001009185
Protein GI 57165412
UniProt ID Q9UKU0
mRNA ID NM_001009185
Length 722
RefSeq Status REVIEWED
MLTFFLVSGGSLWLFVEFVLSLLEKMQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
long-chain-fatty-acid--CoA ligase 6 isoform c
Refseq ID NP_001192176
Protein GI 57165412
UniProt ID Q9UKU0
mRNA ID NM_001205247
Length 722
RefSeq Status REVIEWED
MLTFFLVSGGSLWLFVEFVLSLLEKMQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTEKVIFPRQDDVLISFLPLAHMFERVIQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
long-chain-fatty-acid--CoA ligase 6 isoform d
Refseq ID NP_001192177
Protein GI 327412323
UniProt ID Q9UKU0
mRNA ID NM_001205248
Length 697
RefSeq Status REVIEWED
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
long-chain-fatty-acid--CoA ligase 6 isoform e
Refseq ID NP_001192179
Protein GI 327412323
UniProt ID Q9UKU0
mRNA ID NM_001205250
Length 697
RefSeq Status REVIEWED
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM
long-chain-fatty-acid--CoA ligase 6 isoform f
Refseq ID NP_001192180
Protein GI 327412323
UniProt ID Q9UKU0
mRNA ID NM_001205251
Length 697
RefSeq Status REVIEWED
MQTQEILRILRLPELGDLGQFFRSLSATTLVSMGALAAILAYWFTHRPKALQPPCNLLMQSEEVEDSGGARRSVIGSGPQLLTHYYDDARTMYQVFRRGLSISGNGPCLGFRKPKQPYQWLSYQEVADRAEFLGSGLLQHNCKACTDQFIGVFAQNRPEWIIVELACYTYSMVVVPLYDTLGPGAIRYIINTADISTVIVDKPQKAVLLLEHVERKETPGLKLIILMDPFEEALKERGQKCGVVIKSMQAVEDCGQENHQAPVPPQPDDLSIVCFTSGTTGNPKGAMLTHGNVVADFSGFLKVTESQWAPTCADVHISYLPLAHMFERMVQSVVYCHGGRVGFFQGDIRLLSDDMKALCPTIFPVVPRLLNRMYDKIFSQANTPLKRWLLEFAAKRKQAEVRSGIIRNDSIWDELFFNKIQASLGGCVRMIVTGAAPASPTVLGFLRAALGCQVYEGYGQTECTAGCTFTTPGDWTSGHVGAPLPCNHIKLVDVEELNYWACKGEGEICVRGPNVFKGYLKDPDRTKEALDSDGWLHTGDIGKWLPAGTLKIIDRKKHIFKLAQGEYVAPEKIENIYIRSQPVAQIYVHGDSLKAFLVGIVVPDPEVMPSWAQKRGIEGTYADLCTNKDLKKAILEDMVRLGKESGLHSFEQVKAIHIHSDMFSVQNGLLTPTLKAKRPELREYFKKQIEELYSISM

Gene Information

Entrez Gene ID
Gene Name
acyl-CoA synthetase long-chain family member 6
Gene Symbol
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:UniProtKB C membrane
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005634 IEA:Ensembl C nucleus
GO:0005777 IEA:UniProtKB-KW C peroxisome
GO:0005886 NAS:UniProtKB C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0019899 IPI:UniProtKB F enzyme binding
GO:0004467 IDA:UniProtKB F long-chain fatty acid-CoA ligase activity
GO:0042803 IDA:UniProtKB F protein homodimerization activity
GO:0006637 NAS:UniProtKB P acyl-CoA metabolic process
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0032869 IEA:Ensembl P cellular response to insulin stimulus
GO:0015908 IEA:Ensembl P fatty acid transport
GO:0001676 IDA:UniProtKB P long-chain fatty acid metabolic process
GO:0035338 TAS:Reactome P long-chain fatty-acyl-CoA biosynthetic process
GO:0007405 IEA:Ensembl P neuroblast proliferation
GO:0048666 IEA:Ensembl P neuron development
GO:0008654 IEA:Ensembl P phospholipid biosynthetic process
GO:0010976 IEA:Ensembl P positive regulation of neuron projection development
GO:0010747 IEA:Ensembl P positive regulation of plasma membrane long-chain fatty acid transport
GO:0010867 IEA:Ensembl P positive regulation of triglyceride biosynthetic process
GO:0009629 IEA:Ensembl P response to gravity
GO:0001666 IEA:Ensembl P response to hypoxia
GO:0007584 IEA:Ensembl P response to nutrient
GO:0048545 IEA:Ensembl P response to steroid hormone
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0019432 TAS:Reactome P triglyceride biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04920 Adipocytokine signaling pathway
hsa03320 PPAR signaling pathway
hsa04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-387 fatty acid alpha-oxidation II

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase long-chain family member 6
Protein Entry
ACSL6_HUMAN
UniProt ID
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=9; Name=4; IsoId=Q9UKU0-4; Sequence=Displayed; Name=1; Synonyms=Long, v2; IsoId=Q9UKU0-1; Sequence=VSP_037819; Name=2; Synonyms=Short; IsoId=Q9UKU0-2; Sequence=VSP_021024, VSP_000241; Note=No experimental confirmation available.; Name=3; IsoId=Q9UKU0-3; Sequence=VSP_021024; Note=No experimental confirmation available.; Name=5; Synonyms=v4; IsoId=Q9UKU0-5; Sequence=VSP_037823; Name=6; Synonyms=v5; IsoId=Q9UKU0-6; Sequence=VSP_037821; Name=7; Synonyms=v3; IsoId=Q9UKU0-7; Sequence=VSP_037820, VSP_037822; Name=8; Synonyms=v1; IsoId=Q9UKU0-8; Sequence=VSP_037819, VSP_021024; Note=No experimental confirmation available.; Name=9; IsoId=Q9UKU0-9; Sequence=VSP_046954; Note=No experimental confirmation available.;
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI
Developmental Stage Expression is low at earlier stages of erythroid development but is very high in reticulocytes.
Disease Note=A chromosomal aberration involving ACSL6 may be a cause of acute eosinophilic leukemia (AEL). Translocation t(5;12)(q31;p13) with ETV6.
Disease Note=A chromosomal aberration involving ACSL6 may be a cause of acute myelogenous leukemia with eosinophilia. Translocation t(5;12)(q31;p13) with ETV6.
Disease Note=A chromosomal aberration involving ACSL6 may be a cause of myelodysplastic syndrome with basophilia. Translocation t(5;12)(q31;p13) with ETV6.
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid.
Sequence Caution Sequence=AAH26161.1; Type=Erroneous termination; Positions=72; Note=Translated as Arg.; Evidence= ; Sequence=BAA74860.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the ATP-dependent AMP-binding enzyme family.
Subcellular Location Mitochondrion outer membrane ; Single-pass type III membrane protein . Peroxisome membrane ; Single-pass type III membrane protein {ECO
Tissue Specificity Expressed predominantly in erythrocyte precursors, in particular in reticulocytes, fetal blood cells derived from fetal liver, hemopoietic stem cells from cord blood, bone marrow and brain.

Identical and Related Proteins

Unique RefSeq proteins for LMP001121 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
327412323 RefSeq NP_056071 697 long-chain-fatty-acid--CoA ligase 6 isoform a
57165412 RefSeq NP_001009185 722 long-chain-fatty-acid--CoA ligase 6 isoform b
57165412 RefSeq NP_001192176 722 long-chain-fatty-acid--CoA ligase 6 isoform c
327412323 RefSeq NP_001192177 697 long-chain-fatty-acid--CoA ligase 6 isoform d
327412323 RefSeq NP_001192179 697 long-chain-fatty-acid--CoA ligase 6 isoform e
327412323 RefSeq NP_001192180 697 long-chain-fatty-acid--CoA ligase 6 isoform f

Identical Sequences to LMP001121 proteins

Reference Database Accession Length Protein Name
GI:57165412 DBBJ BAG11245.1 722 acyl-CoA synthetase long-chain family member 6, partial [synthetic construct]
GI:57165412 DBBJ BAG11245.1 722 acyl-CoA synthetase long-chain family member 6, partial [synthetic construct]
GI:327412323 GenBank EAW62358.1 697 acyl-CoA synthetase long-chain family member 6, isoform CRA_d [Homo sapiens]
GI:327412323 GenBank EAW62358.1 697 acyl-CoA synthetase long-chain family member 6, isoform CRA_d [Homo sapiens]
GI:327412323 GenBank EAW62358.1 697 acyl-CoA synthetase long-chain family member 6, isoform CRA_d [Homo sapiens]
GI:327412323 GenBank EAW62358.1 697 acyl-CoA synthetase long-chain family member 6, isoform CRA_d [Homo sapiens]

Related Sequences to LMP001121 proteins

Reference Database Accession Length Protein Name
GI:57165412 DBBJ BAA74860.1 745 KIAA0837 protein, partial [Homo sapiens]
GI:57165412 DBBJ BAA74860.1 745 KIAA0837 protein, partial [Homo sapiens]
GI:327412323 DBBJ BAG37060.1 697 unnamed protein product [Homo sapiens]
GI:327412323 DBBJ BAG37060.1 697 unnamed protein product [Homo sapiens]
GI:327412323 DBBJ BAG37060.1 697 unnamed protein product [Homo sapiens]
GI:327412323 DBBJ BAG37060.1 697 unnamed protein product [Homo sapiens]
GI:57165412 GenBank AFE65747.1 722 long-chain-fatty-acid--CoA ligase 6 isoform b [Macaca mulatta]
GI:57165412 GenBank AFE65747.1 722 long-chain-fatty-acid--CoA ligase 6 isoform b [Macaca mulatta]
GI:327412323 RefSeq NP_056071.2 722 long-chain-fatty-acid--CoA ligase 6 isoform a [Homo sapiens]
GI:327412323 RefSeq NP_056071.2 722 long-chain-fatty-acid--CoA ligase 6 isoform a [Homo sapiens]
GI:327412323 RefSeq NP_056071.2 722 long-chain-fatty-acid--CoA ligase 6 isoform a [Homo sapiens]
GI:327412323 RefSeq NP_056071.2 722 long-chain-fatty-acid--CoA ligase 6 isoform a [Homo sapiens]
GI:327412323 RefSeq XP_003829366.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:327412323 RefSeq XP_003829366.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:327412323 RefSeq XP_003829366.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:327412323 RefSeq XP_003829366.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:57165412 RefSeq XP_004042505.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 2 [Gorilla gorilla gorilla]
GI:57165412 RefSeq XP_004042505.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 2 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042506.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 3 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042506.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 3 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042506.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 3 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042506.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 3 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042507.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 4 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042507.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 4 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042507.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 4 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_004042507.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform 4 [Gorilla gorilla gorilla]
GI:327412323 RefSeq XP_008952933.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:327412323 RefSeq XP_008952933.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:327412323 RefSeq XP_008952933.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:327412323 RefSeq XP_008952933.1 697 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X3 [Pan paniscus]
GI:57165412 RefSeq XP_009207302.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Papio anubis]
GI:57165412 RefSeq XP_009207302.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Papio anubis]
GI:57165412 RefSeq XP_010358315.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Rhinopithecus roxellana]
GI:57165412 RefSeq XP_010358315.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Rhinopithecus roxellana]
GI:57165412 RefSeq XP_010337293.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Saimiri boliviensis boliviensis]
GI:57165412 RefSeq XP_010337293.1 722 PREDICTED: long-chain-fatty-acid--CoA ligase 6 isoform X1 [Saimiri boliviensis boliviensis]