Gene/Proteome Database (LMPD)

LMPD ID
LMP001125
Gene ID
5949
Species
Homo sapiens (Human)
Gene Name
retinol binding protein 3, interstitial
Gene Symbol
RBP3
Synonyms
D10S64; D10S65; D10S66; IRBP; RBPI; RP66
Alternate Names
retinol-binding protein 3; interphotoreceptor retinoid-binding protein
Chromosome
10
Map Location
10q11.2
Summary
Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene duplication events. In the gene, the boundaries of these domains are not defined by exon-intron junctions, as might have been expected. The first three homology domains and part of the fourth are all encoded by the first large exon, which is 3,180 base pairs long. The remainder of the fourth domain is encoded in the last three exons, which are 191, 143, and approximately 740 base pairs long, respectively. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for RBP3

Proteins

retinol-binding protein 3 precursor
Refseq ID NP_002891
Protein GI 4506453
UniProt ID P10745
mRNA ID NM_002900
Length 1247
RefSeq Status REVIEWED
MMREWVLLMSVLLCGLAGPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL
sig_peptide: 1..17 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1966 peptide sequence: MMREWVLLMSVLLCGLA mat_peptide: 18..1247 product: retinol-binding protein 3 calculated_mol_wt: 133416 peptide sequence: GPTHLFQPSLVLDMAKVLLDNYCFPENLLGMQEAIQQAIKSHEILSISDPQTLASVLTAGVQSSLNDPRLVISYEPSTPEPPPQVPALTSLSEEELLAWLQRGLRHEVLEGNVGYLRVDSVPGQEVLSMMGEFLVAHVWGNLMGTSALVLDLRHCTGGQVSGIPYIISYLHPGNTILHVDTIYNRPSNTTTEIWTLPQVLGERYGADKDVVVLTSSQTRGVAEDIAHILKQMRRAIVVGERTGGGALDLRKLRIGESDFFFTVPVSRSLGPLGGGSQTWEGSGVLPCVGTPAEQALEKALAILTLRSALPGVVHCLQEVLKDYYTLVDRVPTLLQHLASMDFSTVVSEEDLVTKLNAGLQAASEDPRLLVRAIGPTETPSWPAPDAAAEDSPGVAPELPEDEAIRQALVDSVFQVSVLPGNVGYLRFDSFADASVLGVLAPYVLRQVWEPLQDTEHLIMDLRHNPGGPSSAVPLLLSYFQGPEAGPVHLFTTYDRRTNITQEHFSHMELPGPRYSTQRGVYLLTSHRTATAAEEFAFLMQSLGWATLVGEITAGNLLHTRTVPLLDTPEGSLALTVPVLTFIDNHGEAWLGGGVVPDAIVLAEEALDKAQEVLEFHQSLGALVEGTGHLLEAHYARPEVVGQTSALLRAKLAQGAYRTAVDLESLASQLTADLQEVSGDHRLLVFHSPGELVVEEAPPPPPAVPSPEELTYLIEALFKTEVLPGQLGYLRFDAMAELETVKAVGPQLVRLVWQQLVDTAALVIDLRYNPGSYSTAIPLLCSYFFEAEPRQHLYSVFDRATSKVTEVWTLPQVAGQRYGSHKDLYILMSHTSGSAAEAFAHTMQDLQRATVIGEPTAGGALSVGIYQVGSSPLYASMPTQMAMSATTGKAWDLAGVEPDITVPMSEALSIAQDIVALRAKVPTVLQTAGKLVADNYASAELGAKMATKLSGLQSRYSRVTSEVALAEILGADLQMLSGDPHLKAAHIPENAKDRIPGIVPMQIPSPEVFEELIKFSFHTNVLEDNIGYLRFDMFGDGELLTQVSRLLVEHIWKKIMHTDAMIIDMRFNIGGPTSSIPILCSYFFDEGPPVLLDKIYSRPDDSVSELWTHAQVVGERYGSKKSMVILTSSVTAGTAEEFTYIMKRLGRALVIGEVTSGGCQPPQTYHVDDTNLYLTIPTARSVGASDGSSWEGVGVTPHVVVPAEEALARAKEMLQHNQLRVKRSPGLQDHL

Gene Information

Entrez Gene ID
5949
Gene Name
retinol binding protein 3, interstitial
Gene Symbol
RBP3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:UniProtKB C extracellular space
GO:0033165 IEA:Ensembl C interphotoreceptor matrix
GO:0031982 IDA:UniProtKB C vesicle
GO:0016918 IEA:UniProtKB-KW F retinal binding
GO:0005501 TAS:ProtInc F retinoid binding
GO:0019841 IEA:Ensembl F retinol binding
GO:0008236 IEA:InterPro F serine-type peptidase activity
GO:0006629 TAS:ProtInc P lipid metabolic process
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:0001523 TAS:Reactome P retinoid metabolic process
GO:0006810 IEA:UniProtKB-KW P transport
GO:0007601 TAS:ProtInc P visual perception

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160102 Diseases associated with visual transduction
REACT_160156 The canonical retinoid cycle in rods (twilight vision)
REACT_160083 The retinoid cycle in cones (daylight vision)
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR029045 ClpP/crotonase-like domain
IPR005151 Tail specific protease

UniProt Annotations

Entry Information

Gene Name
retinol binding protein 3, interstitial
Protein Entry
RET3_HUMAN
UniProt ID
P10745
Species
Human

Comments

Comment Type Description
Caution It is uncertain whether Met-1 or Met-2 is the initiator.
Disease Retinitis pigmentosa 66 (RP66) [MIM
Function IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina.
Sequence Caution Sequence=AAC18875.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the peptidase S41A family.
Subcellular Location Secreted, extracellular space, extracellular matrix, interphotoreceptor matrix. Note=Interphotoreceptor matrix that permeates the space between the retina and the contiguous layer of pigment epithelium cells.

Identical and Related Proteins

Unique RefSeq proteins for LMP001125 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4506453 RefSeq NP_002891 1247 retinol-binding protein 3 precursor

Identical Sequences to LMP001125 proteins

Reference Database Accession Length Protein Name
GI:4506453 GenBank AAA59453.1 1247 interstitial retinol-binding protein 3 [Homo sapiens]
GI:4506453 GenBank AAA36126.1 1247 IRBP precursor [Homo sapiens]
GI:4506453 GenBank EAW50659.1 1247 retinol binding protein 3, interstitial [Homo sapiens]
GI:4506453 SwissProt P10745.2 1247 RecName: Full=Retinol-binding protein 3; AltName: Full=Interphotoreceptor retinoid-binding protein; Short=IRBP; AltName: Full=Interstitial retinol-binding protein; Flags: Precursor [Homo sapiens]

Related Sequences to LMP001125 proteins

Reference Database Accession Length Protein Name
GI:4506453 DBBJ BAJ84061.1 1247 retinol-binding protein 3 [Homo sapiens]
GI:4506453 GenBank AAA59188.1 1246 retinol-binding protein [Homo sapiens]
GI:4506453 GenBank AAC18875.1 1246 interstitial retinol-binding protein precursor [Homo sapiens]
GI:4506453 GenBank AAH39844.1 1247 Retinol binding protein 3, interstitial [Homo sapiens]
GI:4506453 GenBank ACM82328.1 1287 Sequence 7826 from patent US 6812339
GI:4506453 PRF - 1246 interstitial retinol binding protein [Homo sapiens]