Gene/Proteome Database (LMPD)

LMPD ID
LMP001129
Gene ID
12426
Species
Mus musculus (Mouse)
Gene Name
cholecystokinin B receptor
Gene Symbol
Cckbr
Synonyms
CCK2R; CCKR-2
Alternate Names
gastrin/cholecystokinin type B receptor; CCK-BR; CCK2-R; CCK-B receptor; CCK2/gastrin receptor; CCK-B/gastrin receptor; cholecystokinin-2 receptor
Chromosome
7
Map Location
7 E3|7 55.86 cM

Proteins

gastrin/cholecystokinin type B receptor
Refseq ID NP_031653
Protein GI 7106265
UniProt ID P56481
mRNA ID NM_007627
Length 453
RefSeq Status PROVISIONAL
MDLLKLNRSLQGPGPGSGSSLCRPGVSLLNSSSAGNLSCETPRIRGTGTRELELTIRITLYAVIFLMSVGGNVLIIVVLGLSRRLRTVTNAFLLSLAVSDLLLAVACMPFTLLPNLMGTFIFGTVICKAVSYLMGVSVSVSTLNLAAIALERYSAICRPLQARVWQTRSHAARVILATWLLSGLLMVPYPVYTVVQPVGPRILQCMHLWPSERVQQMWSVLLLILLFFIPGVVMAVAYGLISRELYLGLRFDGDNDSETQSRVRNQGGLPGGAAAPGPVHQNGGCRHVTSLTGEDSDGCYVQLPRSRLEMTTLTTPTTGPGPGPRPNQAKLLAKKRVVRMLLVIVLLFFVCWLPVYSANTWRAFDGPGARRALAGAPISFIHLLSYTSACANPLVYCFMHRRFRQACLDTCARCCPRPPRARPRPLPDEDPPTPSIASLSRLSYTTISTLGPG

Gene Information

Entrez Gene ID
12426
Gene Name
cholecystokinin B receptor
Gene Symbol
Cckbr
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0016020 IDA:MGI C membrane
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0015054 ISS:UniProtKB F gastrin receptor activity
GO:0048565 IMP:MGI P digestive tract development
GO:0001696 IMP:MGI P gastric acid secretion
GO:0048732 IMP:MGI P gland development
GO:0008284 ISS:UniProtKB P positive regulation of cell proliferation
GO:0007204 ISS:UniProtKB P positive regulation of cytosolic calcium ion concentration

KEGG Pathway Links

KEGG Pathway ID Description
mmu04020 Calcium signaling pathway
mmu04971 Gastric acid secretion

Domain Information

InterPro Annotations

Accession Description
IPR009126 Cholecystokinin receptor
IPR000276 G protein-coupled receptor, rhodopsin-like
IPR017452 GPCR, rhodopsin-like, 7TM
IPR000314 Gastrin receptor

UniProt Annotations

Entry Information

Gene Name
cholecystokinin B receptor
Protein Entry
GASR_MOUSE
UniProt ID
P56481
Species
Mouse

Comments

Comment Type Description
Function Receptor for gastrin and cholecystokinin. The CKK-B receptors occur throughout the central nervous system where they modulate anxiety, analgesia, arousal, and neuroleptic activity. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system (By similarity). {ECO:0000250}.
Similarity Belongs to the G-protein coupled receptor 1 family. {ECO:0000255|PROSITE-ProRule:PRU00521}.
Subcellular Location Cell membrane; Multi-pass membrane protein.

Identical and Related Proteins

Unique RefSeq proteins for LMP001129 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
7106265 RefSeq NP_031653 453 gastrin/cholecystokinin type B receptor

Identical Sequences to LMP001129 proteins

Reference Database Accession Length Protein Name
GI:7106265 DBBJ BAC25881.1 453 unnamed protein product [Mus musculus]
GI:7106265 GenBank AAG09801.1 453 cholecystokinin-B receptor [Mus musculus]
GI:7106265 GenBank AAI03532.1 453 Cholecystokinin B receptor [Mus musculus]
GI:7106265 GenBank AAI03539.1 453 Cholecystokinin B receptor [Mus musculus]
GI:7106265 GenBank EDL16771.1 453 cholecystokinin B receptor [Mus musculus]
GI:7106265 SwissProt P56481.1 453 RecName: Full=Gastrin/cholecystokinin type B receptor; Short=CCK-B receptor; Short=CCK-BR; AltName: Full=Cholecystokinin-2 receptor; Short=CCK2-R [Mus musculus]

Related Sequences to LMP001129 proteins

Reference Database Accession Length Protein Name
GI:7106265 DBBJ BAC35337.1 453 unnamed protein product [Mus musculus]
GI:7106265 GenBank AAA40925.1 452 cholecystokinin receptor [Rattus norvegicus]
GI:7106265 GenBank AAI03531.1 452 Cholecystokinin B receptor [Mus musculus]
GI:7106265 GenBank EDM18047.1 452 cholecystokinin B receptor, isoform CRA_a [Rattus norvegicus]
GI:7106265 RefSeq XP_006507343.1 452 PREDICTED: gastrin/cholecystokinin type B receptor isoform X1 [Mus musculus]
GI:7106265 SwissProt P30553.1 452 RecName: Full=Gastrin/cholecystokinin type B receptor; Short=CCK-B receptor; Short=CCK-BR; AltName: Full=Cholecystokinin-2 receptor; Short=CCK2-R [Rattus norvegicus]