Gene/Proteome Database (LMPD)

LMPD ID
LMP001137
Gene ID
6256
Species
Homo sapiens (Human)
Gene Name
retinoid X receptor, alpha
Gene Symbol
RXRA
Synonyms
NR2B1
Alternate Names
retinoic acid receptor RXR-alpha; retinoid X nuclear receptor alpha; nuclear receptor subfamily 2 group B member 1
Chromosome
9
Map Location
9q34.3
Summary
Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014]
Orthologs
View orthologs and multiple alignments for RXRA

Proteins

retinoic acid receptor RXR-alpha isoform a
Refseq ID NP_002948
Protein GI 4506755
UniProt ID Q6P3U7
mRNA ID NM_002957
Length 462
RefSeq Status REVIEWED
MDTKHFLPLDFSTQVNSSLTSPTGRGSMAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
retinoic acid receptor RXR-alpha isoform b
Refseq ID NP_001278849
Protein GI 632794852
UniProt ID Q6P3U7
mRNA ID NM_001291920
Length 435
RefSeq Status REVIEWED
MAAPSLHPSLGPGIGSPGQLHSPISTLSSPINGMGPPFSVISSPMGPHSMSVPTTPTLGFSTGSPQLSSPMNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT
retinoic acid receptor RXR-alpha isoform c
Refseq ID NP_001278850
Protein GI 632794854
UniProt ID Q6P3U7
mRNA ID NM_001291921
Length 365
RefSeq Status REVIEWED
MNPVSSSEDIKPPLGLNGVLKVPAHPSGNMASFTKHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDKRQRNRCQYCRYQKCLAMGMKREAVQEERQRGKDRNENEVESTSSANEDMPVERILEAELAVEPKTETYVEANMGLNPSSPNDPVTNICQAADKQLFTLVEWAKRIPHFSELPLDDQVILLRAGWNELLIASFSHRSIAVKDGILLATGLHVHRNSAHSAGVGAIFDRVLTELVSKMRDMQMDKTELGCLRAIVLFNPDSKGLSNPAEVEALREKVYASLEAYCKHKYPEQPGRFAKLLLRLPALRSIGLKCLEHLFFFKLIGDTPIDTFLMEMLEAPHQMT

Gene Information

Entrez Gene ID
6256
Gene Name
retinoid X receptor, alpha
Gene Symbol
RXRA
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000790 IDA:BHF-UCL C nuclear chromatin
GO:0005654 TAS:Reactome C nucleoplasm
GO:0005634 IDA:UniProtKB C nucleus
GO:0004886 TAS:ProtInc F 9-cis retinoic acid receptor activity
GO:0031490 IEA:Ensembl F chromatin DNA binding
GO:0003677 IDA:MGI F DNA binding
GO:0019899 IPI:UniProtKB F enzyme binding
GO:0004879 IDA:BHF-UCL F ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0046982 IDA:UniProtKB F protein heterodimerization activity
GO:0003708 TAS:BHF-UCL F retinoic acid receptor activity
GO:0044323 IDA:UniProtKB F retinoic acid-responsive element binding
GO:0000977 IDA:MGI F RNA polymerase II regulatory region sequence-specific DNA binding
GO:0003700 IDA:UniProtKB F sequence-specific DNA binding transcription factor activity
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0003713 TAS:ProtInc F transcription coactivator activity
GO:0042809 IPI:BHF-UCL F vitamin D receptor binding
GO:0008270 IEA:InterPro F zinc ion binding
GO:0043010 IEA:Ensembl P camera-type eye development
GO:0060038 IEA:Ensembl P cardiac muscle cell proliferation
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0008203 TAS:BHF-UCL P cholesterol metabolic process
GO:0007566 IEA:Ensembl P embryo implantation
GO:0010467 TAS:Reactome P gene expression
GO:0001701 IEA:Ensembl P in utero embryonic development
GO:0001893 IEA:Ensembl P maternal placenta development
GO:0019048 IDA:UniProtKB P modulation by virus of host morphology or physiology
GO:0000122 IDA:BHF-UCL P negative regulation of transcription from RNA polymerase II promoter
GO:0035357 IDA:UniProtKB P peroxisome proliferator activated receptor signaling pathway
GO:0045944 IDA:UniProtKB P positive regulation of transcription from RNA polymerase II promoter
GO:0051289 IDA:MGI P protein homotetramerization
GO:0060687 IEA:Ensembl P regulation of branching involved in prostate gland morphogenesis
GO:0032526 IMP:BHF-UCL P response to retinoic acid
GO:0048384 IMP:BHF-UCL P retinoic acid receptor signaling pathway
GO:0060528 IEA:Ensembl P secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006367 TAS:Reactome P transcription initiation from RNA polymerase II promoter
GO:0055012 IEA:Ensembl P ventricular cardiac muscle cell differentiation
GO:0055010 IEA:Ensembl P ventricular cardiac muscle tissue morphogenesis
GO:0006766 TAS:ProtInc P vitamin metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04932 Non-alcoholic fatty liver disease (NAFLD)
hsa04151 PI3K-Akt signaling pathway
hsa04919 Thyroid hormone signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR021780 Nuclear/hormone receptor activator site AF-1
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR000003 Retinoid X receptor/HNF4
IPR001723 Steroid hormone receptor
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
retinoid X receptor, alpha
Protein Entry
Q6P3U7_HUMAN
UniProt ID
Q6P3U7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P19793-1; Sequence=Displayed; Name=2; IsoId=P19793-2; Sequence=VSP_056565; Note=No experimental confirmation available.;
Domain Composed of three domains: a modulating N-terminal domain (AF1 domain), a DNA-binding domain and a C-terminal ligand-binding domain (AF2 domain).
Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RAR/RXR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. The high affinity ligand for RXRs is 9-cis retinoic acid. RXRA serves as a common heterodimeric partner for a number of nuclear receptors. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence of ligand, the RXR-RAR heterodimers associate with a multiprotein complex containing transcription corepressors that induce histone acetylation, chromatin condensation and transcriptional suppression. On ligand binding, the corepressors dissociate from the receptors and associate with the coactivators leading to transcriptional activation. The RXRA/PPARA heterodimer is required for PPARA transcriptional activity on fatty acid oxidation genes such as ACOX1 and the P450 system genes. {ECO
Interaction Q03463:- (xeno); NbExp=3; IntAct=EBI-78598, EBI-9159704; Q71SY5:MED25; NbExp=4; IntAct=EBI-78598, EBI-394558; Q15788:NCOA1; NbExp=5; IntAct=EBI-78598, EBI-455189; Q9JLI4:Ncoa6 (xeno); NbExp=2; IntAct=EBI-78598, EBI-286271; P27986:PIK3R1; NbExp=8; IntAct=EBI-78598, EBI-79464; P10276:RARA; NbExp=4; IntAct=EBI-78598, EBI-413374; P42224:STAT1; NbExp=2; IntAct=EBI-78598, EBI-1057697;
Ptm Phosphorylated on serine and threonine residues mainly in the N-terminal modulating domain. Constiutively phosphorylated on Ser- 21 in the presence or absence of ligand. Under stress conditions, hyperphosphorylated by activated JNK on Ser-56, Ser-70, Thr-82 and Ser-260 (By similarity). Phosphorylated on Ser-27, in vitro, by PKA. This phosphorylation is required for repression of cAMP- mediated transcriptional activity of RARA. {ECO
Ptm Sumoylation negatively regulates transcriptional activity. Desumoylated specifically by SENP6.
Similarity Belongs to the nuclear hormone receptor family. NR2 subfamily.
Similarity Contains 1 nuclear receptor DNA-binding domain.
Subcellular Location Nucleus {ECO
Subunit Homodimer. Heterodimer with RARA; required for ligand- dependent retinoic acid receptor transcriptional activity. Heterodimer with PPARA (via the leucine-like zipper in the LBD); the interaction is required for PPARA transcriptional activity. Also heterodimerizes with PPARG. Interacts with NCOA3 and NCOA6 coactivators. Interacts with FAM120B (By similarity). Interacts with PELP1, SENP6, SFPQ, DNTTIP2 and RNF8. Interacts (via the DNA binding domain) with HCV core protein; the interaction enhances the transcriptional activities of the RXRA/RARA and the RXRA/PPARA heterodimers. Interacts with PRMT2. Interacts with ASXL1 (By similarity). Interacts with BHLHE40/DEC1, BHLHE41/DEC2, NCOR1 and NCOR2. Interacts in a ligand-dependent fashion with MED1 and NCOA1. {ECO
Tissue Specificity Highly expressed in liver, also found in lung, kidney and heart.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/rxra/";
Web Resource Name=Wikipedia; Note=Retinoid X receptor entry; URL="http://en.wikipedia.org/wiki/Retinoid_X_receptor";

Identical and Related Proteins

Unique RefSeq proteins for LMP001137 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4506755 RefSeq NP_002948 462 retinoic acid receptor RXR-alpha isoform a
632794852 RefSeq NP_001278849 435 retinoic acid receptor RXR-alpha isoform b
632794854 RefSeq NP_001278850 365 retinoic acid receptor RXR-alpha isoform c

Identical Sequences to LMP001137 proteins

Reference Database Accession Length Protein Name
GI:632794854 DBBJ BAG54745.1 365 unnamed protein product [Homo sapiens]
GI:4506755 GenBank AEN39528.1 462 Sequence 10 from patent US 7998986
GI:4506755 GenBank AEP73961.1 462 Sequence 18 from patent US 8013001
GI:4506755 GenBank AFE79585.1 462 retinoic acid receptor RXR-alpha [Macaca mulatta]
GI:4506755 GenBank AFH33516.1 462 retinoic acid receptor RXR-alpha [Macaca mulatta]
GI:4506755 GenBank AFL58955.1 462 Sequence 1 from patent US 8105798
GI:4506755 GenBank AHL57925.1 462 Sequence 382 from patent US 8647822
GI:632794854 PDB 4NQA 365 Chain A, Crystal Structure Of Liganded Hrxr-alpha/hlxr-beta Heterodimer On Dna
GI:632794854 PDB 4NQA 365 Chain H, Crystal Structure Of Liganded Hrxr-alpha/hlxr-beta Heterodimer On Dna
GI:632794854 RefSeq XP_003822498.1 365 PREDICTED: retinoic acid receptor RXR-alpha isoform X2 [Pan paniscus]
GI:632794852 RefSeq XP_008974288.1 435 PREDICTED: retinoic acid receptor RXR-alpha isoform X1 [Pan paniscus]
GI:632794852 RefSeq XP_010371073.1 435 PREDICTED: retinoic acid receptor RXR-alpha isoform X1 [Rhinopithecus roxellana]
GI:632794852 RefSeq XP_010371074.1 435 PREDICTED: retinoic acid receptor RXR-alpha isoform X1 [Rhinopithecus roxellana]
GI:632794854 RefSeq XP_010371075.1 365 PREDICTED: retinoic acid receptor RXR-alpha isoform X2 [Rhinopithecus roxellana]

Related Sequences to LMP001137 proteins

Reference Database Accession Length Protein Name
GI:632794852 EMBL CAJ28057.1 462 unnamed protein product [synthetic construct]
GI:632794852 GenBank AAC95154.1 479 retinoic acid receptor RXR [Cloning vector pERV3]
GI:632794854 GenBank AAC95154.1 479 retinoic acid receptor RXR [Cloning vector pERV3]
GI:4506755 GenBank AAC95154.1 479 retinoic acid receptor RXR [Cloning vector pERV3]
GI:4506755 GenBank AAG02188.1 472 retinoid-X-receptor [Cloning vector pFB-ERV]
GI:632794852 GenBank AAG02188.1 472 retinoid-X-receptor [Cloning vector pFB-ERV]
GI:632794854 GenBank AAG02188.1 472 retinoid-X-receptor [Cloning vector pFB-ERV]
GI:4506755 GenBank AAH63827.1 516 RXRA protein, partial [Homo sapiens]
GI:632794852 GenBank ABA07290.1 462 Sequence 4 from patent US 6906057
GI:632794852 GenBank ACN04137.1 462 Sequence 18 from patent US 7482366
GI:4506755 GenBank JAA13499.1 462 retinoid X receptor, alpha [Pan troglodytes]
GI:4506755 GenBank JAA31907.1 462 retinoid X receptor, alpha [Pan troglodytes]
GI:4506755 GenBank JAA43560.1 462 retinoid X receptor, alpha [Pan troglodytes]
GI:632794852 GenBank AHL57925.1 462 Sequence 382 from patent US 8647822
GI:632794854 RefSeq NP_001278849.1 435 retinoic acid receptor RXR-alpha isoform b [Homo sapiens]
GI:632794854 RefSeq XP_008974288.1 435 PREDICTED: retinoic acid receptor RXR-alpha isoform X1 [Pan paniscus]
GI:632794854 RefSeq XP_010371073.1 435 PREDICTED: retinoic acid receptor RXR-alpha isoform X1 [Rhinopithecus roxellana]
GI:632794854 RefSeq XP_010371074.1 435 PREDICTED: retinoic acid receptor RXR-alpha isoform X1 [Rhinopithecus roxellana]