Gene/Proteome Database (LMPD)

LMPD ID
LMP001138
Gene ID
11669
Species
Mus musculus (Mouse)
Gene Name
aldehyde dehydrogenase 2, mitochondrial
Gene Symbol
Aldh2
Synonyms
Ahd-5; Ahd5
Alternate Names
aldehyde dehydrogenase, mitochondrial; ALDHI; AHD-M1; ALDH-E2; ALDH class 2
Chromosome
5
Map Location
5|5 F-G1
EC Number
1.2.1.3

Proteins

aldehyde dehydrogenase, mitochondrial precursor
Refseq ID NP_033786
Protein GI 6753036
UniProt ID P47738
mRNA ID NM_009656
Length 519
RefSeq Status PROVISIONAL
MLRAALTTVRRGPRLSRLLSAAATSAVPAPNHQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEGVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS
transit_peptide: 1..19 inference: non-experimental evidence, no additional details recorded note: Mitochondrion (By similarity); propagated from UniProtKB/Swiss-Prot (P47738.1) calculated_mol_wt: 2181 peptide sequence: MLRAALTTVRRGPRLSRLL mat_peptide: 20..519 product: Aldehyde dehydrogenase, mitochondrial experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P47738.1) calculated_mol_wt: 54375 peptide sequence: SAAATSAVPAPNHQPEVFCNQIFINNEWHDAVSRKTFPTVNPSTGEVICQVAEGNKEDVDKAVKAARAAFQLGSPWRRMDASDRGRLLYRLADLIERDRTYLAALETLDNGKPYVISYLVDLDMVLKCLRYYAGWADKYHGKTIPIDGDFFSYTRHEPVGVCGQIIPWNFPLLMQAWKLGPALATGNVVVMKVAEQTPLTALYVANLIKEAGFPPGVVNIVPGFGPTAGAAIASHEGVDKVAFTGSTEVGHLIQVAAGSSNLKRVTLELGGKSPNIIMSDADMDWAVEQAHFALFFNQGQCCCAGSRTFVQENVYDEFVERSVARAKSRVVGNPFDSRTEQGPQVDETQFKKILGYIKSGQQEGAKLLCGGGAAADRGYFIQPTVFGDVKDGMTIAKEEIFGPVMQILKFKTIEEVVGRANDSKYGLAAAVFTKDLDKANYLSQALQAGTVWINCYDVFGAQSPFGGYKMSGSGRELGEYGLQAYTEVKTVTVKVPQKNS

Gene Information

Entrez Gene ID
11669
Gene Name
aldehyde dehydrogenase 2, mitochondrial
Gene Symbol
Aldh2
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0004029 IEA:UniProtKB-EC F aldehyde dehydrogenase (NAD) activity
GO:0006068 IEA:UniProtKB-UniPathway P ethanol catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00561 Glycerolipid metabolism
mmu00010 Glycolysis / Gluconeogenesis
mmu00620 Pyruvate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016162 Aldehyde dehydrogenase N-terminal domain
IPR015590 Aldehyde dehydrogenase domain
IPR016163 Aldehyde dehydrogenase, C-terminal
IPR016160 Aldehyde dehydrogenase, cysteine active site
IPR029510 Aldehyde dehydrogenase, glutamic acid active site
IPR016161 Aldehyde/histidinol dehydrogenase

UniProt Annotations

Entry Information

Gene Name
aldehyde dehydrogenase 2, mitochondrial
Protein Entry
ALDH2_MOUSE
UniProt ID
P47738
Species
Mouse

Comments

Comment Type Description
Catalytic Activity An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH.
Function Is capable of converting retinaldehyde to retinoic acid.
Induction By retinoic acid; 3-5 fold increase.
Interaction Q8R104:Sirt3; NbExp=2; IntAct=EBI-2308120, EBI-6999888;
Pathway Alcohol metabolism; ethanol degradation; acetate from ethanol: step 2/2.
Similarity Belongs to the aldehyde dehydrogenase family. {ECO:0000305}.
Subcellular Location Mitochondrion matrix.
Subunit Homotetramer. {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001138 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
6753036 RefSeq NP_033786 519 aldehyde dehydrogenase, mitochondrial precursor

Identical Sequences to LMP001138 proteins

Reference Database Accession Length Protein Name
GI:6753036 GenBank EDL19720.1 519 aldehyde dehydrogenase 2, mitochondrial, isoform CRA_b [Mus musculus]
GI:6753036 GenBank AEQ84589.1 519 Sequence 83 from patent US 8039587
GI:6753036 GenBank AEU53452.1 519 Sequence 83 from patent US 8062891
GI:6753036 GenBank AGO72405.1 519 Sequence 83 from patent US 8470972
GI:6753036 GenBank AGU32396.1 519 Sequence 83 from patent US 8507277
GI:6753036 GenBank AGX48300.1 519 Sequence 83 from patent US 8541550

Related Sequences to LMP001138 proteins

Reference Database Accession Length Protein Name
GI:6753036 DBBJ BAE31741.1 519 unnamed protein product [Mus musculus]
GI:6753036 DBBJ BAE29958.1 519 unnamed protein product [Mus musculus]
GI:6753036 DBBJ BAE30012.1 519 unnamed protein product [Mus musculus]
GI:6753036 DBBJ BAE30669.1 519 unnamed protein product [Mus musculus]
GI:6753036 DBBJ BAE35596.1 519 unnamed protein product [Mus musculus]
GI:6753036 DBBJ BAE27044.1 519 unnamed protein product [Mus musculus]