Gene/Proteome Database (LMPD)

LMPD ID
LMP001142
Gene ID
8310
Species
Homo sapiens (Human)
Gene Name
acyl-CoA oxidase 3, pristanoyl
Gene Symbol
ACOX3
Synonyms
-
Alternate Names
peroxisomal acyl-coenzyme A oxidase 3; BRCACox; pristanoyl-CoA oxidase; branched-chain acyl-CoA oxidase; acyl-Coenzyme A oxidase 3, pristanoyl
Chromosome
4
Map Location
4p15.3
EC Number
1.3.3.6
Summary
Acyl-Coenzyme A oxidase 3 also know as pristanoyl -CoA oxidase (ACOX3)is involved in the desaturation of 2-methyl branched fatty acids in peroxisomes. Unlike the rat homolog, the human gene is expressed in very low amounts in liver such that its mRNA was undetectable by routine Northern-blot analysis or its product by immunoblotting or by enzyme activity measurements. However the human cDNA encoding a 700 amino acid protein with a peroxisomal targeting C-terminal tripeptide S-K-L was isolated and is thought to be expressed under special conditions such as specific developmental stages or in a tissue specific manner in tissues that have not yet been examined. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ACOX3

Proteins

peroxisomal acyl-coenzyme A oxidase 3 isoform a
Refseq ID NP_003492
Protein GI 156104864
UniProt ID O15254
mRNA ID NM_003501
Length 700
RefSeq Status VALIDATED
MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRGGYFSGEQAGEVLESAVLALCSQLKDDAVALVDVIAPPDFVLDSPIGRADGELYKNLWGAVLQESKVLERASWWPEFSVNKPVIGSLKSKL
peroxisomal acyl-coenzyme A oxidase 3 isoform b
Refseq ID NP_001095137
Protein GI 156104866
UniProt ID O15254
mRNA ID NM_001101667
Length 624
RefSeq Status VALIDATED
MASTVEGGDTALLPEFPRGPLDAYRARASFSWKELALFTEGEGMLRFKKTIFSALENDPLFARSPGADLSLEKYRELNFLRCKRIFEYDFLSVEDMFKSPLKVPALIQCLGMYDSSLAAKYLLHSLVFGSAVYSSGSERHLTYIQKIFRMEIFGCFALTELSHGSNTKAIRTTAHYDPATEEFIIHSPDFEAAKFWVGNMGKTATHAVVFAKLCVPGDQCHGLHPFIVQIRDPKTLLPMPGVMVGDIGKKLGQNGLDNGFAMFHKVRVPRQSLLNRMGDVTPEGTYVSPFKDVRQRFGASLGSLSSGRVSIVSLAILNLKLAVAIALRFSATRRQFGPTEEEEIPVLEYPMQQWRLLPYLAAVYALDHFSKSLFLDLVELQRGLASGDRSARQAELGREIHALASASKPLASWTTQQGIQECREACGGHGYLAMNRLGVLRDDNDPNCTYEGDNNILLQQTSNYLLGLLAHQVHDGACFRSPLKSVDFLDAYPGILDQKFEVSSVADCLDSAVALAAYKWLVCYLLRETYQKLNQEKRSGSSDFEARNKCQVSHGRPLALAFVELTVVQRFHEHVHQPSVPPSLRAVLGRLSALYALWSLSRHAALLYRAERRCSCPGRRDRSS

Gene Information

Entrez Gene ID
8310
Gene Name
acyl-CoA oxidase 3, pristanoyl
Gene Symbol
ACOX3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016020 IDA:UniProtKB C membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005782 TAS:Reactome C peroxisomal matrix
GO:0005777 IDA:UniProtKB C peroxisome
GO:0003995 IEA:InterPro F acyl-CoA dehydrogenase activity
GO:0050660 IEA:InterPro F flavin adenine dinucleotide binding
GO:0016402 TAS:Reactome F pristanoyl-CoA oxidase activity
GO:0005102 IPI:UniProtKB F receptor binding
GO:0044255 TAS:Reactome P cellular lipid metabolic process
GO:0033540 TAS:Reactome P fatty acid beta-oxidation using acyl-CoA oxidase
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa03320 PPAR signaling pathway
hsa04146 Peroxisome
hsa04024 cAMP signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR009075 Acyl-CoA dehydrogenase/oxidase C-terminal
IPR009100 Acyl-CoA dehydrogenase/oxidase, N-terminal and middle domain
IPR012258 Acyl-CoA oxidase
IPR002655 Acyl-CoA oxidase, C-terminal
IPR006091 Acyl-CoA oxidase/dehydrogenase, central domain

UniProt Annotations

Entry Information

Gene Name
acyl-CoA oxidase 3, pristanoyl
Protein Entry
ACOX3_HUMAN
UniProt ID
O15254
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O15254-1; Sequence=Displayed; Name=2; IsoId=O15254-2; Sequence=VSP_023355, VSP_023356; Note=No experimental confirmation available.;
Catalytic Activity Acyl-CoA + O(2) = trans-2,3-dehydroacyl-CoA + H(2)O(2).
Cofactor Name=FAD; Xref=ChEBI
Function Oxidizes the CoA-esters of 2-methyl-branched fatty acids.
Pathway Lipid metabolism; peroxisomal fatty acid beta-oxidation.
Similarity Belongs to the acyl-CoA oxidase family.
Subcellular Location Peroxisome .

Identical and Related Proteins

Unique RefSeq proteins for LMP001142 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
156104864 RefSeq NP_003492 700 peroxisomal acyl-coenzyme A oxidase 3 isoform a
156104866 RefSeq NP_001095137 624 peroxisomal acyl-coenzyme A oxidase 3 isoform b

Identical Sequences to LMP001142 proteins

Reference Database Accession Length Protein Name
GI:156104866 EMBL CBU96016.1 624 unnamed protein product [Homo sapiens]
GI:156104864 GenBank EAW82340.1 700 acyl-Coenzyme A oxidase 3, pristanoyl, isoform CRA_b [Homo sapiens]
GI:156104866 GenBank AGX52693.1 624 Sequence 5741 from patent US 8541208
GI:156104866 GenBank AGX57630.1 624 Sequence 15603 from patent US 8541208
GI:156104866 GenBank AGX63414.1 624 Sequence 26932 from patent US 8541208
GI:156104866 GenBank AIC50079.1 624 ACOX3, partial [synthetic construct]
GI:156104864 RefSeq XP_005248068.1 700 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [Homo sapiens]
GI:156104866 RefSeq XP_005248070.1 624 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 isoform X3 [Homo sapiens]
GI:156104864 SwissProt O15254.2 700 RecName: Full=Peroxisomal acyl-coenzyme A oxidase 3; AltName: Full=Branched-chain acyl-CoA oxidase; Short=BRCACox; AltName: Full=Pristanoyl-CoA oxidase [Homo sapiens]

Related Sequences to LMP001142 proteins

Reference Database Accession Length Protein Name
GI:156104864 DBBJ BAG36053.1 700 unnamed protein product [Homo sapiens]
GI:156104864 EMBL CBF65746.1 700 unnamed protein product [Homo sapiens]
GI:156104864 EMBL CBU85836.1 700 unnamed protein product [Homo sapiens]
GI:156104864 EMBL CBU90617.1 700 unnamed protein product [Homo sapiens]
GI:156104864 EMBL CBU96033.1 700 unnamed protein product [Homo sapiens]
GI:156104864 GenBank EAW82339.1 731 acyl-Coenzyme A oxidase 3, pristanoyl, isoform CRA_a [Homo sapiens]
GI:156104866 GenBank EAW82339.1 731 acyl-Coenzyme A oxidase 3, pristanoyl, isoform CRA_a [Homo sapiens]
GI:156104866 GenBank EAW82340.1 700 acyl-Coenzyme A oxidase 3, pristanoyl, isoform CRA_b [Homo sapiens]
GI:156104866 GenBank EAW82341.1 655 acyl-Coenzyme A oxidase 3, pristanoyl, isoform CRA_c [Homo sapiens]
GI:156104866 RefSeq NP_003492.2 700 peroxisomal acyl-coenzyme A oxidase 3 isoform a [Homo sapiens]
GI:156104866 RefSeq XP_005248068.1 700 PREDICTED: peroxisomal acyl-coenzyme A oxidase 3 isoform X1 [Homo sapiens]
GI:156104866 SwissProt O15254.2 700 RecName: Full=Peroxisomal acyl-coenzyme A oxidase 3; AltName: Full=Branched-chain acyl-CoA oxidase; Short=BRCACox; AltName: Full=Pristanoyl-CoA oxidase [Homo sapiens]