Gene/Proteome Database (LMPD)

LMPD ID
LMP001145
Gene ID
9091
Species
Homo sapiens (Human)
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class Q
Gene Symbol
PIGQ
Synonyms
GPI1; c407A10.1
Chromosome
16
Map Location
16p13.3
EC Number
2.4.1.198
Summary
This gene is involved in the first step in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor is a glycolipid found on many blood cells and serves to anchor proteins to the cell surface. This gene encodes a N-acetylglucosaminyl transferase component that is part of the complex that catalyzes transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc to phosphatidylinositol (PI). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2012]
Orthologs
View orthologs and multiple alignments for PIGQ

Proteins

phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 1
Refseq ID NP_683721
Protein GI 22538453
UniProt ID Q9BRB3
mRNA ID NM_148920
Length 760
RefSeq Status REVIEWED
MVLKAFFPTCCVSTDSGLLVGRWVPEQSSAVVLAVLHFPFIPIQVKQLLAQVRQASQVGVAVLGTWCHCRQEPEESLGRFLESLGAVFPHEPWLRLCRERGGTFWSCEATHRQAPTAPGAPGEDQVMLIFYDQRQVLLSQLHLPTVLPDRQAGATTASTGGLAAVFDTVARSEVLFRSDRFDEGPVRLSHWQSEGVEASILAELARRASGPICLLLASLLSLVSAVSACRVFKLWPLSFLGSKLSTCEQLRHRLEHLTLIFSTRKAENPAQLMRKANTVASVLLDVALGLMLLSWLHGRSRIGHLADALVPVADHVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIHLMSPFVEHILWHVGLSACLGLTVALSLLSDIIALLTFHIYCFYVYGARLYCLKIHGLSSLWRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILLFLLPTTALYYLVFTLLRLLVVAVQGLIHLLVDLINSLPLYSLGLRLCRPYRLADKPTALQPRGAHLPPPQLWLPPQALLGRPVPQAVPWGAHLPLEAERGQAGLRELLARLAPPHGHSQPSALPGWHQLSWRMSCALWTLLCAPEHGRPCYHTLGLEVIGSEQMWGWPARLAALHHWHCLPWDPLPTCCGHHGGEHSNPRCPEHCPMPTLCTQVQRVRPPQQPQVEGWSPWGLPSGSALAVGVEGPCQDEPPSPRHPLAPSAEQHPASGGLKQSLTPVPSGPGPSLPEPHGVYLRMFPGEVAL
phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 2
Refseq ID NP_004195
Protein GI 22538450
UniProt ID Q9BRB3
mRNA ID NM_004204
Length 581
RefSeq Status REVIEWED
MVLKAFFPTCCVSTDSGLLVGRWVPEQSSAVVLAVLHFPFIPIQVKQLLAQVRQASQVGVAVLGTWCHCRQEPEESLGRFLESLGAVFPHEPWLRLCRERGGTFWSCEATHRQAPTAPGAPGEDQVMLIFYDQRQVLLSQLHLPTVLPDRQAGATTASTGGLAAVFDTVARSEVLFRSDRFDEGPVRLSHWQSEGVEASILAELARRASGPICLLLASLLSLVSAVSACRVFKLWPLSFLGSKLSTCEQLRHRLEHLTLIFSTRKAENPAQLMRKANTVASVLLDVALGLMLLSWLHGRSRIGHLADALVPVADHVAEELQHLLQWLMGAPAGLKMNRALDQVLGRFFLYHIHLWISYIHLMSPFVEHILWHVGLSACLGLTVALSLLSDIIALLTFHIYCFYVYGARLYCLKIHGLSSLWRLFRGKKWNVLRQRVDSCSYDLDQLFIGTLLFTILLFLLPTTALYYLVFTLLRLLVVAVQGLIHLLVDLINSLPLYSLGLRLCRPYRLAAGVKFRVLRHEAGRPLRLLMQINPLPYSRVVHTYRLPSCGCHPKHSWGALCRKLFLGELIYPWRQRGDKQD

Gene Information

Entrez Gene ID
9091
Gene Name
phosphatidylinositol glycan anchor biosynthesis, class Q
Gene Symbol
PIGQ
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 TAS:Reactome C endoplasmic reticulum membrane
GO:0000506 IEA:Ensembl C glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0017176 IEA:UniProtKB-EC F phosphatidylinositol N-acetylglucosaminyltransferase activity
GO:0006501 TAS:Reactome P C-terminal protein lipidation
GO:0005975 TAS:ProtInc P carbohydrate metabolic process
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0043687 TAS:Reactome P post-translational protein modification
GO:0016254 TAS:Reactome P preassembly of GPI anchor in ER membrane

KEGG Pathway Links

KEGG Pathway ID Description
hsa00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
ko00563 Glycosylphosphatidylinositol(GPI)-anchor biosynthesis
hsa01100 Metabolic pathways

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_952 Synthesis of glycosylphosphatidylinositol (GPI)

Domain Information

InterPro Annotations

Accession Description
IPR007720 N-acetylglucosaminyl transferase component

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol glycan anchor biosynthesis, class Q
Protein Entry
PIGQ_HUMAN
UniProt ID
Q9BRB3
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BRB3-1; Sequence=Displayed; Note=No experimental confirmation available.; Name=2; IsoId=Q9BRB3-2; Sequence=VSP_007281, VSP_007282; Name=3; IsoId=Q9BRB3-3; Sequence=VSP_007279, VSP_007280; Note=No experimental confirmation available.;
Catalytic Activity UDP-N-acetyl-D-glucosamine + 1-phosphatidyl- 1D-myo-inositol = UDP + 6-(N-acetyl-alpha-D-glucosaminyl)-1- phosphatidyl-1D-myo-inositol.
Function Part of the complex catalyzing the transfer of N- acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis.
Pathway Glycolipid biosynthesis; glycosylphosphatidylinositol- anchor biosynthesis.
Similarity Belongs to the PIGQ family.
Subcellular Location Membrane ; Multi-pass membrane protein .
Subunit Associates with PIGA, PIGC, PIGH, PIGP and DPM2. The latter is not essential for activity.

Identical and Related Proteins

Unique RefSeq proteins for LMP001145 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22538453 RefSeq NP_683721 760 phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 1
22538450 RefSeq NP_004195 581 phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 2

Identical Sequences to LMP001145 proteins

Reference Database Accession Length Protein Name
GI:22538453 GenBank AAH06377.1 760 Phosphatidylinositol glycan anchor biosynthesis, class Q [Homo sapiens]
GI:22538450 GenBank AAK61235.1 581 N-acetylglucosamyl transferase component GPI1 [Homo sapiens]
GI:22538450 GenBank EAW85796.1 581 phosphatidylinositol glycan, class Q, isoform CRA_b [Homo sapiens]
GI:22538450 GenBank EAW85797.1 581 phosphatidylinositol glycan, class Q, isoform CRA_b [Homo sapiens]
GI:22538450 GenBank EAW85799.1 581 phosphatidylinositol glycan, class Q, isoform CRA_b [Homo sapiens]
GI:22538453 GenBank ABM83588.1 760 phosphatidylinositol glycan anchor biosynthesis, class Q [synthetic construct]
GI:22538453 GenBank ABM86829.1 760 phosphatidylinositol glycan anchor biosynthesis, class Q, partial [synthetic construct]
GI:22538453 GenBank AIC55527.1 760 PIGQ, partial [synthetic construct]
GI:22538453 SwissProt Q9BRB3.3 760 RecName: Full=Phosphatidylinositol N-acetylglucosaminyltransferase subunit Q; AltName: Full=N-acetylglucosamyl transferase component GPI1; AltName: Full=Phosphatidylinositol-glycan biosynthesis class Q protein; Short=PIG-Q [Homo sapiens]

Related Sequences to LMP001145 proteins

Reference Database Accession Length Protein Name
GI:22538450 DBBJ BAA24948.1 581 GPI1 [Homo sapiens]
GI:22538450 DBBJ BAG36993.1 581 unnamed protein product [Homo sapiens]
GI:22538450 GenBank AAC32661.1 581 N-acetylglucosaminyl transferase component Gpi1 [Homo sapiens]
GI:22538453 GenBank EAW85795.1 760 phosphatidylinositol glycan, class Q, isoform CRA_a [Homo sapiens]
GI:22538453 GenBank EAW85797.1 581 phosphatidylinositol glycan, class Q, isoform CRA_b [Homo sapiens]
GI:22538453 GenBank EAW85800.1 760 phosphatidylinositol glycan, class Q, isoform CRA_a [Homo sapiens]
GI:22538450 GenBank JAA12172.1 581 phosphatidylinositol glycan anchor biosynthesis, class Q [Pan troglodytes]
GI:22538450 RefSeq XP_003808854.1 620 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1 [Pan paniscus]
GI:22538453 RefSeq XP_004056927.1 760 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform 2 [Gorilla gorilla gorilla]
GI:22538450 RefSeq XP_008959155.1 581 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X3 [Pan paniscus]
GI:22538453 RefSeq XP_009248522.1 598 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1 [Pongo abelii]
GI:22538453 RefSeq XP_009248523.1 598 PREDICTED: phosphatidylinositol N-acetylglucosaminyltransferase subunit Q isoform X1 [Pongo abelii]