Gene/Proteome Database (LMPD)

LMPD ID
LMP001147
Gene ID
643418
Species
Homo sapiens (Human)
Gene Name
lipase, family member N
Gene Symbol
LIPN
Synonyms
ARCI8; LI4; LIPL4; bA186O14.3
Alternate Names
lipase member N; lipase-like abhydrolase domain-containing protein 4
Chromosome
10
Map Location
10q23.31
EC Number
3.1.1.-
Summary
The gene encodes a lipase that is highly expressed in granular keratinocytes in the epidermis, and plays a role in the differentiation of keratinocytes. Mutations in this gene are associated with lamellar ichthyosis type 4. [provided by RefSeq, Dec 2011]
Orthologs
View orthologs and multiple alignments for LIPN

Proteins

lipase member N precursor
Refseq ID NP_001095939
Protein GI 156447044
UniProt ID Q5VXI9
mRNA ID NM_001102469
Length 398
RefSeq Status REVIEWED
MMWLLLTTTCLICGTLNAGGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKYPTGIFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKAYS
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1999 peptide sequence: MMWLLLTTTCLICGTLNA mat_peptide: 19..398 product: Lipase member N experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q5VXI9.2) calculated_mol_wt: 43554 peptide sequence: GGFLDLENEVNPEVWMNTSEIIIYNGYPSEEYEVTTEDGYILLVNRIPYGRTHARSTGPRPVVYMQHALFADNAYWLENYANGSLGFLLADAGYDVWMGNSRGNTWSRRHKTLSETDEKFWAFSFDEMAKYDLPGVIDFIVNKTGQEKLYFIGHSLGTTIGFVAFSTMPELAQRIKMNFALGPTISFKYPTGIFTRFFLLPNSIIKAVFGTKGFFLEDKKTKIASTKICNNKILWLICSEFMSLWAGSNKKNMNQSRMDVYMSHAPTGSSVHNILHIKQLYHSDEFRAYDWGNDADNMKHYNQSHPPIYDLTAMKVPTAIWAGGHDVLVTPQDVARILPQIKSLHYFKLLPDWNHFDFVWGLDAPQRMYSEIIALMKAYS

Gene Information

Entrez Gene ID
643418
Gene Name
lipase, family member N
Gene Symbol
LIPN
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0016788 IEA:InterPro F hydrolase activity, acting on ester bonds
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1
IPR025483 Lipase, eukaryotic
IPR006693 Partial AB-hydrolase lipase domain

UniProt Annotations

Entry Information

Gene Name
lipase, family member N
Protein Entry
LIPN_HUMAN
UniProt ID
Q5VXI9
Species
Human

Comments

Comment Type Description
Developmental Stage Up-regulated during epidermal differentiation.
Disease Ichthyosis, congenital, autosomal recessive 8 (ARCI8) [MIM
Function Plays a highly specific role in the last step of keratinocyte differentiation. May have an essential function in lipid metabolism of the most differentiated epidermal layers.
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Subcellular Location Secreted .
Tissue Specificity Highly expressed in the epidermis in the granular keratinocytes. Also detected in other tissues, although at much lower levels, including lung and spleen.

Identical and Related Proteins

Unique RefSeq proteins for LMP001147 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
156447044 RefSeq NP_001095939 398 lipase member N precursor

Identical Sequences to LMP001147 proteins

Reference Database Accession Length Protein Name
GI:156447044 GenBank ABR08388.1 398 lipase N [Homo sapiens]
GI:156447044 RefSeq XP_005270106.1 398 PREDICTED: lipase member N isoform X1 [Homo sapiens]
GI:156447044 SwissProt Q5VXI9.2 398 RecName: Full=Lipase member N; AltName: Full=Lipase-like abhydrolase domain-containing protein 4; Flags: Precursor [Homo sapiens]

Related Sequences to LMP001147 proteins

Reference Database Accession Length Protein Name
GI:156447044 GenBank EHH19202.1 398 hypothetical protein EGK_19870 [Macaca mulatta]
GI:156447044 RefSeq XP_001082459.2 398 PREDICTED: lipase member N-like [Macaca mulatta]
GI:156447044 RefSeq XP_003255228.1 398 PREDICTED: lipase member N [Nomascus leucogenys]
GI:156447044 RefSeq XP_521546.3 398 PREDICTED: lipase member N [Pan troglodytes]
GI:156447044 RefSeq XP_003810557.1 398 PREDICTED: lipase member N [Pan paniscus]
GI:156447044 RefSeq XP_004049793.1 398 PREDICTED: lipase member N [Gorilla gorilla gorilla]