Gene/Proteome Database (LMPD)
LMPD ID
LMP001148
Gene ID
Species
Mus musculus (Mouse)
Gene Name
aldehyde dehydrogenase family 3, subfamily A2
Gene Symbol
Synonyms
AI194803; Ahd-3; Ahd-3r; Ahd3; Ahd3-r; Aldh4; Aldh4-r; FALDH
Alternate Names
fatty aldehyde dehydrogenase; aldehyde dehydrogenase 3; aldehyde dehydrogenase family 3 member A2; alcohol dehydrogenase family 3, subfamily A2; aldehyde dehydrogenase 4, liver microsomal (class 3) regulator
Chromosome
11
Map Location
11 B2|11 37.96 cM
EC Number
1.2.1.3
Proteins
| fatty aldehyde dehydrogenase | |
|---|---|
| Refseq ID | NP_031463 |
| Protein GI | 75677435 |
| UniProt ID | P47740 |
| mRNA ID | NM_007437 |
| Length | 484 |
| RefSeq Status | VALIDATED |
| MERQVLRLRQAFRSGRSRPLRFRLQQLEALRRMVQEREKEILAAIAADLSKSELNAYSHEVITILGEIDFMLGNLPELASARPAKKNLLTMMDEAYVQPEPLGVVLIIGAWNYPFVLTMQPLVGAIAAGNAAIVKPSELSENTAKILAELLPQYLDQDLYAIVNGGIPETTELLKQRFDHILYTGNTAVGKIVMEAAAKHLTPVTLELGGKSPCYIDRDCDLDVACRRIAWGKYMNCGQTCIAPDYILCEASLQNQIVQKIKETVKDFYGENIKASPDYERIINLRHFKRLQSLLKGQKIAFGGEMDEATRYLAPTILTDVDPNSKVMQEEIFGPILPIVSVKNVDEAINFINDREKPLALYVFSRNNKLIKRVIDETSSGGVTGNDVIMHFTVNSLPFGGVGASGMGAYHGKYSFDTFSHQRPCLLKGLKGESVNKLRYPPNSESKVSWAKFFLLKQFNKGRLGMLLFVCLVAVAAVIVKDQL | |
Gene Information
Entrez Gene ID
Gene Name
aldehyde dehydrogenase family 3, subfamily A2
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005783 | IDA:UniProtKB | C | endoplasmic reticulum |
| GO:0070062 | IEA:Ensembl | C | extracellular vesicular exosome |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005743 | IDA:MGI | C | mitochondrial inner membrane |
| GO:0005739 | IDA:MGI | C | mitochondrion |
| GO:0005777 | IEA:Ensembl | C | peroxisome |
| GO:0004030 | IEA:InterPro | F | aldehyde dehydrogenase [NAD(P)+] activity |
| GO:0046577 | IEA:Ensembl | F | long-chain-alcohol oxidase activity |
| GO:0050061 | IEA:Ensembl | F | long-chain-aldehyde dehydrogenase activity |
| GO:0052814 | IEA:Ensembl | F | medium-chain-aldehyde dehydrogenase activity |
| GO:0006081 | IEA:InterPro | P | cellular aldehyde metabolic process |
| GO:0007417 | IEA:Ensembl | P | central nervous system development |
| GO:0008544 | IEA:Ensembl | P | epidermis development |
| GO:0007422 | IEA:Ensembl | P | peripheral nervous system development |
| GO:0033306 | IEA:Ensembl | P | phytol metabolic process |
| GO:0006714 | IEA:Ensembl | P | sesquiterpenoid metabolic process |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR016162 | Aldehyde dehydrogenase N-terminal domain |
| IPR012394 | Aldehyde dehydrogenase NAD(P)-dependent |
| IPR015590 | Aldehyde dehydrogenase domain |
| IPR016163 | Aldehyde dehydrogenase, C-terminal |
| IPR016160 | Aldehyde dehydrogenase, cysteine active site |
| IPR029510 | Aldehyde dehydrogenase, glutamic acid active site |
| IPR016161 | Aldehyde/histidinol dehydrogenase |
UniProt Annotations
Entry Information
Gene Name
aldehyde dehydrogenase family 3, subfamily A2
Protein Entry
AL3A2_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | An aldehyde + NAD(+) + H(2)O = a carboxylate + NADH. |
| Function | Catalyzes the oxidation of long-chain aliphatic aldehydes to fatty acids. Responsible for conversion of the sphingosine 1-phosphate (S1P) degradation product hexadecenal to hexadecenoic acid (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the aldehyde dehydrogenase family. {ECO:0000305}. |
| Subcellular Location | Endoplasmic reticulum membrane; Single-pass membrane protein; Cytoplasmic side. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001148 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 75677435 | RefSeq | NP_031463 | 484 | fatty aldehyde dehydrogenase |
Identical Sequences to LMP001148 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:75677435 | DBBJ | BAE40936.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | DBBJ | BAE24523.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | DBBJ | BAE37166.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | DBBJ | BAE34928.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | DBBJ | BAE41628.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | SwissProt | P47740.2 | 484 | RecName: Full=Fatty aldehyde dehydrogenase; AltName: Full=Aldehyde dehydrogenase 3; AltName: Full=Aldehyde dehydrogenase family 3 member A2 [Mus musculus] |
Related Sequences to LMP001148 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:75677435 | DBBJ | BAC39639.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | DBBJ | BAE30991.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | DBBJ | BAE31455.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | DBBJ | BAE31505.1 | 484 | unnamed protein product [Mus musculus] |
| GI:75677435 | GenBank | AAK01550.1 | 484 | fatty aldehyde dehydrogenase [Mus musculus] |
| GI:75677435 | RefSeq | XP_006532093.1 | 487 | PREDICTED: fatty aldehyde dehydrogenase isoform X2 [Mus musculus] |