Gene/Proteome Database (LMPD)

LMPD ID
LMP001151
Gene ID
99035
Species
Mus musculus (Mouse)
Gene Name
oleoyl-ACP hydrolase
Gene Symbol
Olah
Synonyms
AI607300; E230009B14Rik; Thedc1
Alternate Names
S-acyl fatty acid synthase thioesterase, medium chain; thioesterase II; thioesterase domain containing 1; thioesterase domain-containing protein 1
Chromosome
2
Map Location
2 A1|2
EC Number
3.1.2.14

Proteins

S-acyl fatty acid synthase thioesterase, medium chain
Refseq ID NP_666033
Protein GI 22122331
UniProt ID Q8R197
mRNA ID NM_145921
Length 265
RefSeq Status VALIDATED
METAVYAKSTRNEKVLNCLCQKPDALFKLICFPWAGGGSTHFAKWGRKINGLLEVHAVRLAGRETRFEEPFSNDIYQIAEEVVTALLPIIRDKAFAFFGHSFGSYIAFITALHLKEKYKMEPLHIFVSSASAPHSEFRPQVPDINKLSEEQIRDHLLIFGGTPKHLIEDQDFLKQCIPLLKADVDIVKKFIFDKPSKALLSRDITCFIGSEDVVKDIEGWKDITSGKFDVLKLPGDHFYLMEPNNEDFIKNYIVKCLELSSLDYF

Gene Information

Entrez Gene ID
99035
Gene Name
oleoyl-ACP hydrolase
Gene Symbol
Olah
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016295 IEA:UniProtKB-EC F myristoyl-[acyl-carrier-protein] hydrolase activity
GO:0004320 IEA:UniProtKB-EC F oleoyl-[acyl-carrier-protein] hydrolase activity
GO:0016296 IEA:UniProtKB-EC F palmitoyl-[acyl-carrier-protein] hydrolase activity
GO:0006633 IEA:UniProtKB-KW P fatty acid biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00061 Fatty acid biosynthesis
mmu00061 Fatty acid biosynthesis
mmu01100 Metabolic pathways

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY-5148 acyl-CoA hydrolysis

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR001031 Thioesterase
IPR012223 Thioesterase type II, NRPS/PKS/S-FAS

UniProt Annotations

Entry Information

Gene Name
oleoyl-ACP hydrolase
Protein Entry
SAST_MOUSE
UniProt ID
Q8R197
Species
Mouse

Comments

Comment Type Description
Catalytic Activity Oleoyl-[acyl-carrier-protein] + H(2)O = [acyl- carrier-protein] + oleate.
Function In fatty acid biosynthesis chain termination and release of the free fatty acid product is achieved by hydrolysis of the thio ester by a thioesterase I, a component of the fatty acid synthetase complex. The chain length of the released fatty acid is usually C16. However, in the mammary glands of non-ruminant mammals, and in the uropygial gland of certain waterfowl there exists a second thioesterase which releases medium-chain length fatty acids (C8 to C2) (By similarity). {ECO:0000250}.
Similarity Belongs to the thioesterase family. {ECO:0000305}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001151 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
22122331 RefSeq NP_666033 265 S-acyl fatty acid synthase thioesterase, medium chain

Identical Sequences to LMP001151 proteins

Reference Database Accession Length Protein Name
GI:22122331 DBBJ BAC39932.1 265 unnamed protein product [Mus musculus]
GI:22122331 DBBJ BAE22784.1 265 unnamed protein product [Mus musculus]
GI:22122331 GenBank AAH25001.1 265 Oleoyl-ACP hydrolase [Mus musculus]
GI:22122331 GenBank EDL07926.1 265 oleoyl-ACP hydrolase, isoform CRA_b [Mus musculus]
GI:22122331 RefSeq XP_006497634.1 265 PREDICTED: S-acyl fatty acid synthase thioesterase, medium chain isoform X1 [Mus musculus]
GI:22122331 SwissProt Q8R197.1 265 RecName: Full=S-acyl fatty acid synthase thioesterase, medium chain; AltName: Full=Oleoyl-ACP hydrolase; AltName: Full=Thioesterase II; AltName: Full=Thioesterase domain-containing protein 1 [Mus musculus]

Related Sequences to LMP001151 proteins

Reference Database Accession Length Protein Name
GI:22122331 EMBL CAA68411.1 263 unnamed protein product [Rattus norvegicus]
GI:22122331 GenBank AAA41578.1 263 S-acyl fatty acid sunthetase thio ester hydrolase, medium chain [Rattus norvegicus]
GI:22122331 GenBank AAQ52093.1 263 Sequence 3 from patent US 6593099
GI:22122331 GenBank EDL07925.1 269 oleoyl-ACP hydrolase, isoform CRA_a, partial [Mus musculus]
GI:22122331 RefSeq XP_008770108.1 263 PREDICTED: S-acyl fatty acid synthase thioesterase, medium chain isoform X1 [Rattus norvegicus]
GI:22122331 SwissProt P08635.1 263 RecName: Full=S-acyl fatty acid synthase thioesterase, medium chain; AltName: Full=Oleoyl-ACP hydrolase; AltName: Full=Thioesterase II; AltName: Full=Thioesterase domain-containing protein 1 [Rattus norvegicus]