Gene/Proteome Database (LMPD)

LMPD ID
LMP001166
Gene ID
2224
Species
Homo sapiens (Human)
Gene Name
farnesyl diphosphate synthase
Gene Symbol
FDPS
Synonyms
FPPS; FPS
Alternate Names
farnesyl pyrophosphate synthase; FPP synthase; FPP synthetase; geranyltranstransferase; dimethylallyltranstransferase; (2E,6E)-farnesyl diphosphate synthase; farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase
Chromosome
1
Map Location
1q22
EC Number
2.5.1.10
Summary
This gene encodes an enzyme that catalyzes the production of geranyl pyrophosphate and farnesyl pyrophosphate from isopentenyl pyrophosphate and dimethylallyl pyrophosphate. The resulting product, farnesyl pyrophosphate, is a key intermediate in cholesterol and sterol biosynthesis, a substrate for protein farnesylation and geranylgeranylation, and a ligand or agonist for certain hormone receptors and growth receptors. Drugs that inhibit this enzyme prevent the post-translational modifications of small GTPases and have been used to treat diseases related to bone resorption. Multiple pseudogenes have been found on chromosomes 1, 7, 14, 15, 21 and X. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2008]
Orthologs
View orthologs and multiple alignments for FDPS

Proteins

farnesyl pyrophosphate synthase isoform a
Refseq ID NP_001129293
Protein GI 209571582
UniProt ID P14324
mRNA ID NM_001135821
Length 419
RefSeq Status REVIEWED
MPLSRWLRSVGVFLLPAPYWAPRERWLGSLRRPSLVHGYPVLAWHSARCWCQAWTEEPRALCSSLRMNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
farnesyl pyrophosphate synthase isoform a
Refseq ID NP_001995
Protein GI 4503685
UniProt ID P14324
mRNA ID NM_002004
Length 419
RefSeq Status REVIEWED
Protein sequence is identical to GI:209571582 (mRNA isoform)
farnesyl pyrophosphate synthase isoform b
Refseq ID NP_001129294
Protein GI 209571584
UniProt ID P14324
mRNA ID NM_001135822
Length 353
RefSeq Status REVIEWED
MNGDQNSDVYAQEKQDFVQHFSQIVRVLTEDEMGHPEIGDAIARLKEVLEYNAIGGKYNRGLTVVVAFRELVEPRKQDADSLQRAWTVGWCVELLQAFFLVADDIMDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK
farnesyl pyrophosphate synthase isoform b
Refseq ID NP_001229753
Protein GI 338797808
UniProt ID P14324
mRNA ID NM_001242824
Length 353
RefSeq Status REVIEWED
Protein sequence is identical to GI:209571584 (mRNA isoform)
farnesyl pyrophosphate synthase isoform c
Refseq ID NP_001229754
Protein GI 338797810
UniProt ID P14324
mRNA ID NM_001242825
Length 248
RefSeq Status REVIEWED
MDSSLTRRGQICWYQKPGVGLDAINDANLLEACIYRLLKLYCREQPYYLNLIELFLQSSYQTEIGQTLDLLTAPQGNVDLVRFTEKRYKSIVKYKTAFYSFYLPIAAAMYMAGIDGEKEHANAKKILLEMGEFFQIQDDYLDLFGDPSVTGKIGTDIQDNKCSWLVVQCLQRATPEQYQILKENYGQKEAEKVARVKALYEELDLPAVFLQYEEDSYSHIMALIEQYAAPLPPAVFLGLARKIYKRRK

Gene Information

Entrez Gene ID
2224
Gene Name
farnesyl diphosphate synthase
Gene Symbol
FDPS
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0005829 TAS:Reactome C cytosol
GO:0005739 IEA:Ensembl C mitochondrion
GO:0005634 IDA:HPA C nucleus
GO:0004161 IEA:UniProtKB-EC F dimethylallyltranstransferase activity
GO:0004337 IEA:UniProtKB-EC F geranyltranstransferase activity
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0044822 IDA:UniProtKB F poly(A) RNA binding
GO:0006695 TAS:Reactome P cholesterol biosynthetic process
GO:0045337 IEA:UniProtKB-UniPathway P farnesyl diphosphate biosynthetic process
GO:0033384 IEA:UniProtKB-UniPathway P geranyl diphosphate biosynthetic process
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0016032 IEA:UniProtKB-KW P viral process

KEGG Pathway Links

KEGG Pathway ID Description
hsa05166 HTLV-I infection
hsa05164 Influenza A

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase

UniProt Annotations

Entry Information

Gene Name
farnesyl diphosphate synthase
Protein Entry
FPPS_HUMAN
UniProt ID
P14324
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P14324-1; Sequence=Displayed; Name=2; IsoId=P14324-2; Sequence=VSP_046958;
Catalytic Activity Dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate.
Catalytic Activity Geranyl diphosphate + isopentenyl diphosphate = diphosphate + (2E,6E)-farnesyl diphosphate.
Cofactor Name=Mg(2+); Xref=ChEBI
Enzyme Regulation Inactivated by interferon-induced RSAD2. This inactivation may result of disruption of lipid rafts at the plasma membrane, and thus have an antiviral effect since many enveloped viruses need lipid rafts to bud efficiently out of the cell.
Function Key enzyme in isoprenoid biosynthesis which catalyzes the formation of farnesyl diphosphate (FPP), a precursor for several classes of essential metabolites including sterols, dolichols, carotenoids, and ubiquinones. FPP also serves as substrate for protein farnesylation and geranylgeranylation. Catalyzes the sequential condensation of isopentenyl pyrophosphate with the allylic pyrophosphates, dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate.
Pathway Isoprenoid biosynthesis; farnesyl diphosphate biosynthesis; farnesyl diphosphate from geranyl diphosphate and isopentenyl diphosphate: step 1/1.
Pathway Isoprenoid biosynthesis; geranyl diphosphate biosynthesis; geranyl diphosphate from dimethylallyl diphosphate and isopentenyl diphosphate: step 1/1.
Sequence Caution Sequence=BAA03523.2; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence= ;
Similarity Belongs to the FPP/GGPP synthase family.
Subcellular Location Cytoplasm.
Subunit Homodimer. Interacts with RSAD2. Interacts with HTLV-1 protein p13(II). {ECO

Identical and Related Proteins

Unique RefSeq proteins for LMP001166 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
209571582 RefSeq NP_001129293 419 farnesyl pyrophosphate synthase isoform a
209571584 RefSeq NP_001129294 353 farnesyl pyrophosphate synthase isoform b
338797810 RefSeq NP_001229754 248 farnesyl pyrophosphate synthase isoform c

Identical Sequences to LMP001166 proteins

Reference Database Accession Length Protein Name
GI:338797810 GenBank EAW53075.1 248 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase), isoform CRA_a [Homo sapiens]
GI:209571582 GenBank JAA20636.1 419 farnesyl diphosphate synthase [Pan troglodytes]
GI:209571582 GenBank JAA28793.1 419 farnesyl diphosphate synthase [Pan troglodytes]
GI:209571582 GenBank AIC48744.1 419 FDPS, partial [synthetic construct]
GI:338797810 RefSeq XP_003949640.1 248 PREDICTED: farnesyl pyrophosphate synthase isoform X3 [Pan troglodytes]
GI:209571582 RefSeq XP_004026970.1 419 PREDICTED: farnesyl pyrophosphate synthase isoform 3 [Gorilla gorilla gorilla]
GI:209571582 RefSeq XP_004026971.1 419 PREDICTED: farnesyl pyrophosphate synthase isoform 4 [Gorilla gorilla gorilla]
GI:338797810 RefSeq XP_004026972.1 248 PREDICTED: farnesyl pyrophosphate synthase isoform 5 [Gorilla gorilla gorilla]
GI:209571584 RefSeq XP_005245020.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X2 [Homo sapiens]
GI:209571582 RefSeq XP_008968430.1 419 PREDICTED: farnesyl pyrophosphate synthase isoform X1 [Pan paniscus]
GI:209571584 RefSeq XP_008968434.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X5 [Pan paniscus]
GI:209571584 RefSeq XP_008968435.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X5 [Pan paniscus]
GI:209571584 RefSeq XP_008968436.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X5 [Pan paniscus]
GI:209571584 RefSeq XP_009431758.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X2 [Pan troglodytes]
GI:209571584 RefSeq XP_009431762.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X2 [Pan troglodytes]

Related Sequences to LMP001166 proteins

Reference Database Accession Length Protein Name
GI:209571582 DBBJ BAA03523.2 420 KIAA1293, partial [Homo sapiens]
GI:209571582 EMBL CAH91070.1 419 hypothetical protein [Pongo abelii]
GI:209571584 GenBank AAH10004.1 419 Farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) [Homo sapiens]
GI:209571582 GenBank ACM85832.1 420 Sequence 11330 from patent US 6812339
GI:209571584 GenBank AFO15179.1 419 Sequence 663 from patent US 8211634
GI:209571582 GenBank JAA09023.1 419 farnesyl diphosphate synthase [Pan troglodytes]
GI:209571584 GenBank JAA20635.1 419 farnesyl diphosphate synthase (farnesyl pyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) [Pan troglodytes]
GI:209571584 GenBank JAA20636.1 419 farnesyl diphosphate synthase [Pan troglodytes]
GI:209571584 GenBank JAA28793.1 419 farnesyl diphosphate synthase [Pan troglodytes]
GI:209571582 RefSeq NP_001125620.1 419 farnesyl pyrophosphate synthase [Pongo abelii]
GI:338797810 RefSeq NP_001229753.1 353 farnesyl pyrophosphate synthase isoform b [Homo sapiens]
GI:209571584 RefSeq XP_003949639.1 419 PREDICTED: farnesyl pyrophosphate synthase isoform X1 [Pan troglodytes]
GI:338797810 RefSeq XP_004026968.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform 1 [Gorilla gorilla gorilla]
GI:338797810 RefSeq XP_004026969.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform 2 [Gorilla gorilla gorilla]
GI:338797810 RefSeq XP_008968434.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X5 [Pan paniscus]
GI:338797810 RefSeq XP_008968435.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X5 [Pan paniscus]
GI:338797810 RefSeq XP_008968436.1 353 PREDICTED: farnesyl pyrophosphate synthase isoform X5 [Pan paniscus]
GI:209571582 RefSeq XP_009241539.1 419 PREDICTED: farnesyl pyrophosphate synthase isoform X1 [Pongo abelii]