Gene/Proteome Database (LMPD)

LMPD ID
LMP001167
Gene ID
14473
Species
Mus musculus (Mouse)
Gene Name
group specific component
Gene Symbol
Gc
Synonyms
DBP; VDB
Alternate Names
vitamin D-binding protein; gc-globulin
Chromosome
5
Map Location
5 E1|5 44.32 cM

Proteins

vitamin D-binding protein precursor
Refseq ID NP_032122
Protein GI 51172612
UniProt ID P21614
mRNA ID NM_008096
Length 476
RefSeq Status VALIDATED
MKRVLVLLLALAFGHALERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQVNQLVKEVVSLTEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERKLCMAALSHQPQEFPTYVEPTNDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTKNYLSMVGSCCTSANPTVCFVKERLQMKHLSLLTTMSNRVCSQYAAYGKEKSRLSHLIKLAQKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPEHTIKICQNLSKKNSKFEECCQENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFELSRRTQVPEVFLSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS
sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1752 peptide sequence: MKRVLVLLLALAFGHA mat_peptide: 17..476 product: Vitamin D-binding protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P21614.2) calculated_mol_wt: 51866 peptide sequence: LERGRDYEKDKVCNELAMLGKEDFRSLSLILYSRKFSSSTFEQVNQLVKEVVSLTEECCAEGADPTCYDTRTSELSVKSCESDAPFPVHPGTPECCTKEGLERKLCMAALSHQPQEFPTYVEPTNDEICEAFRRDPKGFADQFLYEYSSNYGQAPLPLLVAYTKNYLSMVGSCCTSANPTVCFVKERLQMKHLSLLTTMSNRVCSQYAAYGKEKSRLSHLIKLAQKVPTANLENVLPLAEDFTEILSRCCESTSEDCMASELPEHTIKICQNLSKKNSKFEECCQENTPMNIFMCTYFMPAAEPLQLPAIKLPTGKDLCGQSTTQAMDQYTFELSRRTQVPEVFLSKVLEPTLKTLRECCDTQDSVACFSTQSPLLKRQLTSFIEKGQEMCADYSENTFTEYKKKLAERLRTKTPNTSPAELKDMVEKHSDFASKCCSINSPPLYCSSQIDAEMIDTLQS

Gene Information

Entrez Gene ID
14473
Gene Name
group specific component
Gene Symbol
Gc
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0072562 IEA:Ensembl C blood microparticle
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0003779 ISS:UniProtKB F actin binding
GO:1902118 IEA:Ensembl F calcidiol binding
GO:0051183 IEA:InterPro F vitamin transporter activity
GO:0042359 IDA:MGI P vitamin D metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
5892760 Metabolism
5892799 Metabolism of lipids and lipoproteins
5893447 Metabolism of steroid hormones and vitamin D
5893566 Vitamin D (calciferol) metabolism

Domain Information

InterPro Annotations

Accession Description
IPR000264 ALB/AFP/VDB
IPR020857 Serum albumin, conserved site
IPR020858 Serum albumin-like
IPR014760 Serum albumin, N-terminal
IPR000213 Vitamin D-binding protein
IPR015247 Vitamin D binding protein, domain III

UniProt Annotations

Entry Information

Gene Name
group specific component
Protein Entry
VTDB_MOUSE
UniProt ID
P21614
Species
Mouse

Comments

Comment Type Description
Function Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes.
Similarity Belongs to the ALB/AFP/VDB family. {ECO:0000255|PROSITE-ProRule:PRU00769}.
Similarity Contains 3 albumin domains. {ECO:0000255|PROSITE- ProRule:PRU00769}.
Subcellular Location Secreted.

Identical and Related Proteins

Unique RefSeq proteins for LMP001167 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
51172612 RefSeq NP_032122 476 vitamin D-binding protein precursor

Identical Sequences to LMP001167 proteins

Reference Database Accession Length Protein Name
GI:51172612 GenBank AAH10762.1 476 Group specific component [Mus musculus]
GI:51172612 GenBank AAH51395.2 476 Group specific component [Mus musculus]
GI:51172612 SwissProt P21614.2 476 RecName: Full=Vitamin D-binding protein; Short=DBP; Short=VDB; AltName: Full=Gc-globulin; AltName: Full=Group-specific component; Flags: Precursor [Mus musculus]

Related Sequences to LMP001167 proteins

Reference Database Accession Length Protein Name
GI:51172612 DBBJ BAB27297.1 476 unnamed protein product [Mus musculus]
GI:51172612 GenBank AAA37669.1 472 vitamin D-binding protein, partial [Mus musculus]
GI:51172612 GenBank AAA41082.1 476 vitamin D-binding protein precursor [Rattus norvegicus]
GI:51172612 GenBank AAH78891.1 476 Group specific component [Rattus norvegicus]
GI:51172612 GenBank EDL88538.1 476 group specific component, isoform CRA_b [Rattus norvegicus]
GI:51172612 RefSeq NP_036696.2 476 vitamin D-binding protein precursor [Rattus norvegicus]