Gene/Proteome Database (LMPD)

LMPD ID
LMP001168
Gene ID
14081
Species
Mus musculus (Mouse)
Gene Name
acyl-CoA synthetase long-chain family member 1
Gene Symbol
Acsl1
Synonyms
Acas; Acas1; Acs; FACS; Facl2; LACS 1; LACS1
Alternate Names
long-chain-fatty-acid--CoA ligase 1; acetate-CoA ligase; acetyl-CoA synthetase; long-chain acyl-CoA synthetase 1; fatty acid Coenzyme A ligase, long chain 2; acetyl-Coenzyme A synthetase 1 (ADP forming)
Chromosome
8
Map Location
8|8 B2
EC Number
6.2.1.3
Summary
The protein encoded by this gene belongs to a family of acyl coenzyme A synthetase proteins, which convert long chain fatty acids to acyl CoA products via an ATP-dependent pathway. This enzyme is enriched in heart, liver and adipose tissue, where it functions in lipid synthesis and mitochondrial and peroxisomal beta-oxidation. In addition, it is expressed in monocytes and macrophages where it appears to have a functionally distinct role in mediating inflammatory and innate immune responses. A pseudogene of this gene is found on chromosome 5. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]
Orthologs
View orthologs and multiple alignments for Acsl1

Proteins

long-chain-fatty-acid--CoA ligase 1
Refseq ID NP_032007
Protein GI 31560705
UniProt ID P41216
mRNA ID NM_007981
Length 699
RefSeq Status REVIEWED
MEVHELFRYFRMPELIDIRQYVRTLPTNTLMGFGAFAALTTFWYATRPKALKPPCDLSMQSVEIAGTTDGIRRSAVLEDDKLLVYYYDDVRTMYDGFQRGIQVSNNGPCLGSRKPNQPYEWISYKEVAELAECIGSGLIQKGFKPCSEQFIGLFSQNRPEWVIVEQGCFSYSMVVVPLYDTLGADAITYIVNKAELSVIFADKPEKAKLLLEGVENKLTPCLKIIVIMDSYGSDLVERGKKCGVEIISLKALEDLGRVNRVKPKPPEPEDLAIICFTSGTTGNPKGAMITHQNIINDCSGFIKATESAFIASTDDVLISFLPLAHMFETVVECVMLCHGAKIGFFQGDIRLLMDDLKVLQPTIFPVVPRLLNRMFDRIFGQANTSLKRWLLDFASKRKEAELRSGIVRNNSLWDKLIFHKIQSSLGGKVRLMITGAAPVSATVLTFLRTALGCQFYEGYGQTECTAGCCLSLPGDWTAGHVGAPMPCNYVKLVDVEEMNYLASKGEGEVCVKGANVFKGYLKDPARTAEALDKDGWLHTGDIGKWLPNGTLKIIDRKKHIFKLAQGEYIAPEKIENIYLRSEAVAQVFVHGESLQAFLIAVVVPDVESLPSWAQKRGLQGSFEELCRNKDINKAILDDLLKLGKEAGLKPFEQVKGIAVHPELFSIDNGLLTPTLKAKRPELRNYFRSQIDELYATIKI

Gene Information

Entrez Gene ID
14081
Gene Name
acyl-CoA synthetase long-chain family member 1
Gene Symbol
Acsl1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IEA:UniProtKB-KW C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0005741 IEA:UniProtKB-KW C mitochondrial outer membrane
GO:0005739 IDA:MGI C mitochondrion
GO:0005778 IEA:Ensembl C peroxisomal membrane
GO:0005886 IEA:Ensembl C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0004467 IEA:UniProtKB-EC F long-chain fatty acid-CoA ligase activity
GO:0033211 IMP:MGI P adiponectin-activated signaling pathway
GO:0008610 IEA:Ensembl P lipid biosynthetic process
GO:0044539 IEA:Ensembl P long-chain fatty acid import
GO:0071902 IMP:MGI P positive regulation of protein serine/threonine kinase activity
GO:0042493 IEA:Ensembl P response to drug
GO:0007584 IEA:Ensembl P response to nutrient
GO:0034201 IEA:Ensembl P response to oleic acid
GO:0014070 IEA:Ensembl P response to organic cyclic compound
GO:0006641 IEA:Ensembl P triglyceride metabolic process
GO:0042178 IEA:Ensembl P xenobiotic catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu04920 Adipocytokine signaling pathway
mmu03320 PPAR signaling pathway
mmu04146 Peroxisome

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase long-chain family member 1
Protein Entry
ACSL1_MOUSE
UniProt ID
P41216
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + a long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
Function Activation of long-chain fatty acids for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially uses oleate, arachidonate, eicosapentaenoate and docosahexaenoate as substrates (By similarity). {ECO:0000250}.
Similarity Belongs to the ATP-dependent AMP-binding enzyme family. {ECO:0000305}.
Subcellular Location Mitochondrion outer membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Peroxisome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Microsome membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Single-pass type III membrane protein {ECO:0000250}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001168 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31560705 RefSeq NP_032007 699 long-chain-fatty-acid--CoA ligase 1

Identical Sequences to LMP001168 proteins

Reference Database Accession Length Protein Name
GI:31560705 GenBank AGX57014.1 699 Sequence 14347 from patent US 8541208
GI:31560705 RefSeq XP_006509327.1 699 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X3 [Mus musculus]
GI:31560705 RefSeq XP_006509328.1 699 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X4 [Mus musculus]
GI:31560705 RefSeq XP_006509329.1 699 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X5 [Mus musculus]
GI:31560705 RefSeq NP_001289092.1 699 long-chain-fatty-acid--CoA ligase 1 [Mus musculus]
GI:31560705 SwissProt P41216.2 699 RecName: Full=Long-chain-fatty-acid--CoA ligase 1; AltName: Full=Long-chain acyl-CoA synthetase 1; Short=LACS 1 [Mus musculus]

Related Sequences to LMP001168 proteins

Reference Database Accession Length Protein Name
GI:31560705 DBBJ BAA14136.1 699 long-chain acyl-CoA synthetase [Rattus norvegicus]
GI:31560705 GenBank AAA52193.1 699 long chain fatty acyl CoA synthetase [Mus musculus]
GI:31560705 GenBank ADT54644.1 699 Sequence 122 from patent US 7842783
GI:31560705 RefSeq XP_006253184.1 699 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X1 [Rattus norvegicus]
GI:31560705 RefSeq XP_006509325.1 758 PREDICTED: long-chain-fatty-acid--CoA ligase 1 isoform X1 [Mus musculus]
GI:31560705 SwissProt P18163.1 699 RecName: Full=Long-chain-fatty-acid--CoA ligase 1; AltName: Full=Long-chain acyl-CoA synthetase 1; Short=LACS 1; AltName: Full=Long-chain-fatty-acid--CoA ligase, liver isozyme [Rattus norvegicus]