Gene/Proteome Database (LMPD)

LMPD ID
LMP001184
Gene ID
8435
Species
Homo sapiens (Human)
Gene Name
sterol O-acyltransferase 2
Gene Symbol
SOAT2
Synonyms
ACACT2; ACAT2; ARGP2
Alternate Names
sterol O-acyltransferase 2; ACAT-2; cholesterol acyltransferase 2; acyl-CoA:cholesterol acyltransferase 2; acyl Co-A: cholesterol acyltransferase 2; acyl coenzyme A:cholesterol acyltransferase 2; acyl-coenzyme A:cholesterol acyltransferase 2
Chromosome
12
Map Location
12q13.13
EC Number
2.3.1.26
Summary
Summary:This gene is a member of a small family of acyl coenzyme A:cholesterol acyltransferases. The gene encodes a membrane-bound enzyme localized in the endoplasmic reticulum that produces intracellular cholesterol esters from long-chain fatty acyl CoA and cholesterol. The cholesterol esters are then stored as cytoplasmic lipid droplets inside the cell. The enzyme is implicated in cholesterol absorption in the intestine and in the assembly and secretion of apolipoprotein B-containing lipoproteins such as very low density lipoprotein (VLDL). Several alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for SOAT2

Proteins

sterol O-acyltransferase 2
Refseq ID NP_003569
Protein GI 4507147
UniProt ID O75908
mRNA ID NM_003578
Length 522
RefSeq Status REVIEWED
MEPGGARLRLQRTEGLGGERERQPCGDGNTETHRAPDLVQWTRHMEAVKAQLLEQAQGQLRELLDRAMREAIQSYPSQDKPLPPPPPGSLSRTQEPSLGKQKVFIIRKSLLDELMEVQHFRTIYHMFIAGLCVFIISTLAIDFIDEGRLLLEFDLLIFSFGQLPLALVTWVPMFLSTLLAPYQALRLWARGTWTQATGLGCALLAAHAVVLCALPVHVAVEHQLPPASRCVLVFEQVRFLMKSYSFLREAVPGTLRARRGEGIQAPSFSSYLYFLFCPTLIYRETYPRTPYVRWNYVAKNFAQALGCVLYACFILGRLCVPVFANMSREPFSTRALVLSILHATLPGIFMLLLIFFAFLHCWLNAFAEMLRFGDRMFYRDWWNSTSFSNYYRTWNVVVHDWLYSYVYQDGLRLLGARARGVAMLGVFLVSAVAHEYIFCFVLGFFYPVMLILFLVIGGMLNFMMHDQRTGPAWNVLMWTMLFLGQGIQVSLYCQEWYARRHCPLPQATFWGLVTPRSWSCHT

Gene Information

Entrez Gene ID
8435
Gene Name
sterol O-acyltransferase 2
Gene Symbol
SOAT2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005903 IDA:BHF-UCL C brush border
GO:0005783 IDA:BHF-UCL C endoplasmic reticulum
GO:0005789 IDA:BHF-UCL C endoplasmic reticulum membrane
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0034736 IDA:BHF-UCL F cholesterol O-acyltransferase activity
GO:0015485 IDA:BHF-UCL F cholesterol binding
GO:0000062 IDA:BHF-UCL F fatty-acyl-CoA binding
GO:0016746 TAS:ProtInc F transferase activity, transferring acyl groups
GO:0033344 IMP:BHF-UCL P cholesterol efflux
GO:0034435 IDA:BHF-UCL P cholesterol esterification
GO:0042632 TAS:BHF-UCL P cholesterol homeostasis
GO:0008203 IDA:BHF-UCL P cholesterol metabolic process
GO:0030299 IC:BHF-UCL P intestinal cholesterol absorption
GO:0010742 TAS:BHF-UCL P macrophage derived foam cell differentiation
GO:0034379 IMP:BHF-UCL P very-low-density lipoprotein particle assembly

KEGG Pathway Links

KEGG Pathway ID Description
hsa00100 Steroid biosynthesis
ko00100 Steroid biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR004299 Membrane bound O-acyl transferase, MBOAT
IPR014371 Sterol O-acyltransferase, ACAT/DAG/ARE types

UniProt Annotations

Entry Information

Gene Name
sterol O-acyltransferase 2
Protein Entry
SOAT2_HUMAN
UniProt ID
O75908
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=ACAD2a; IsoId=O75908-1; Sequence=Displayed; Name=2; Synonyms=ACAD2b; IsoId=O75908-2; Sequence=VSP_057159; Note=Lower enzymatic activity; Name=3; Synonyms=ACAD2c; IsoId=O75908-3; Sequence=VSP_057158, VSP_057160; Note=Lower enzymatic activity; Name=4; IsoId=O75908-4; Sequence=VSP_057161, VSP_057162; Note=No experimental confirmation available;
Catalytic Activity Acyl-CoA + cholesterol = CoA + cholesterol ester.
Function Plays a role in lipoprotein assembly and dietary cholesterol absorption. In addition to its acyltransferase activity, it may act as a ligase. May provide cholesteryl esters for lipoprotein secretion from hepatocytes and intestinal mucosa.
Similarity Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.
Subcellular Location Endoplasmic reticulum membrane; Multi-pass membrane protein.
Subunit May form homo- or heterodimers.
Tissue Specificity Expression seems confined in hepatocytes and enterocytes.

Identical and Related Proteins

Unique RefSeq proteins for LMP001184 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4507147 RefSeq NP_003569 522 sterol O-acyltransferase 2

Identical Sequences to LMP001184 proteins

Reference Database Accession Length Protein Name
GI:4507147 GenBank AAC63998.1 522 acyl coenzyme A:cholesterol acyltransferase 2 [Homo sapiens]
GI:4507147 GenBank AAK18275.1 522 acyl-CoA:cholesterol acyltransferase-2 [Homo sapiens]
GI:4507147 GenBank EAW96665.1 522 sterol O-acyltransferase 2 [Homo sapiens]
GI:4507147 GenBank ACM85532.1 522 Sequence 11030 from patent US 6812339
GI:4507147 SwissProt O75908.1 522 RecName: Full=Sterol O-acyltransferase 2; AltName: Full=Acyl-coenzyme A:cholesterol acyltransferase 2; Short=ACAT-2; AltName: Full=Cholesterol acyltransferase 2 [Homo sapiens]

Related Sequences to LMP001184 proteins

Reference Database Accession Length Protein Name
GI:4507147 EMBL CDM22166.1 522 unnamed protein product [Homo sapiens]
GI:4507147 GenBank AAC78335.2 522 acyl Co-A: cholesterol acyltransferase-2 [Homo sapiens]
GI:4507147 GenBank AAK48829.1 522 acyl coenzyme A: cholesterol acyltransferase-2 [Homo sapiens]
GI:4507147 GenBank AAH96090.1 522 Sterol O-acyltransferase 2 [Homo sapiens]
GI:4507147 GenBank AAH96092.1 522 Sterol O-acyltransferase 2 [Homo sapiens]
GI:4507147 GenBank AAH96091.1 522 Sterol O-acyltransferase 2 [Homo sapiens]