Gene/Proteome Database (LMPD)
LMPD ID
LMP001191
Gene ID
Species
Homo sapiens (Human)
Gene Name
glutathione peroxidase 3 (plasma)
Gene Symbol
Synonyms
GPx-P; GSHPx-3; GSHPx-P
Alternate Names
glutathione peroxidase 3; GPx-3; plasma glutathione peroxidase; extracellular glutathione peroxidase
Chromosome
5
Map Location
5q23
EC Number
1.11.1.9
Summary
This gene product belongs to the glutathione peroxidase family, which functions in the detoxification of hydrogen peroxide. It contains a selenocysteine (Sec) residue at its active site. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008]
Orthologs
Proteins
| glutathione peroxidase 3 precursor | |
|---|---|
| Refseq ID | NP_002075 |
| Protein GI | 6006001 |
| UniProt ID | P22352 |
| mRNA ID | NM_002084 |
| Length | 226 |
| RefSeq Status | REVIEWED |
| MARLLQASCLLSLLLAGFVSQSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK | |
| sig_peptide: 1..20 calculated_mol_wt: 2107 peptide sequence: MARLLQASCLLSLLLAGFVS mat_peptide: 21..226 product: glutathione peroxidase 3 calculated_mol_wt: 23464 peptide sequence: QSRGQEKSKMDCHGGISGTIYEYGALTIDGEEYIPFKQYAGKYVLFVNVASYUGLTGQYIELNALQEELAPFGLVILGFPCNQFGKQEPGENSEILPTLKYVRPGGGFVPNFQLFEKGDVNGEKEQKFYTFLKNSCPPTSELLGTSDRLFWEPMKVHDIRWNFEKFLVGPDGIPIMRWHHRTTVSNVKMDILSYMRRQAALGVKRK | |
Gene Information
Entrez Gene ID
Gene Name
glutathione peroxidase 3 (plasma)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005576 | TAS:Reactome | C | extracellular region |
| GO:0005615 | IDA:UniProtKB | C | extracellular space |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0004602 | IDA:UniProtKB | F | glutathione peroxidase activity |
| GO:0008430 | IDA:UniProtKB | F | selenium binding |
| GO:0008134 | TAS:UniProtKB | F | transcription factor binding |
| GO:0042744 | TAS:UniProtKB | P | hydrogen peroxide catabolic process |
| GO:0051289 | IDA:UniProtKB | P | protein homotetramerization |
| GO:0006982 | TAS:UniProtKB | P | response to lipid hydroperoxide |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa04918 | Thyroid hormone synthesis |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_172715 | Detoxification of Reactive Oxygen Species |
Domain Information
UniProt Annotations
Entry Information
Gene Name
glutathione peroxidase 3 (plasma)
Protein Entry
GPX3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | 2 glutathione + H(2)O(2) = glutathione disulfide + 2 H(2)O. |
| Function | Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. |
| Ptm | The N-terminus is blocked. |
| Similarity | Belongs to the glutathione peroxidase family. |
| Subcellular Location | Secreted. |
| Subunit | Homotetramer. |
| Tissue Specificity | Secreted in plasma. |
| Web Resource | Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/gpx3/"; |
| Web Resource | Name=Wikipedia; Note=Glutathione peroxidase entry; URL="http://en.wikipedia.org/wiki/Glutathione_peroxidase"; |
Identical and Related Proteins
Unique RefSeq proteins for LMP001191 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 6006001 | RefSeq | NP_002075 | 226 | glutathione peroxidase 3 precursor |
Identical Sequences to LMP001191 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6006001 | EMBL | CAA41228.2 | 226 | glutathione peroxidase [Homo sapiens] |
| GI:6006001 | GenBank | AAH50378.2 | 226 | Glutathione peroxidase 3 (plasma) [Homo sapiens] |
| GI:6006001 | GenBank | AAH13601.1 | 226 | Glutathione peroxidase 3 (plasma) [Homo sapiens] |
| GI:6006001 | GenBank | AAH35841.1 | 226 | Glutathione peroxidase 3 (plasma) [Homo sapiens] |
| GI:6006001 | RefSeq | NP_001108629.1 | 226 | glutathione peroxidase 3 precursor [Pan troglodytes] |
| GI:6006001 | SwissProt | P22352.2 | 226 | RecName: Full=Glutathione peroxidase 3; Short=GPx-3; Short=GSHPx-3; AltName: Full=Extracellular glutathione peroxidase; AltName: Full=Plasma glutathione peroxidase; Short=GPx-P; Short=GSHPx-P; Flags: Precursor [Homo sapiens] |
Related Sequences to LMP001191 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:6006001 | DBBJ | BAA00525.1 | 226 | glutathione peroxidase [Homo sapiens] |
| GI:6006001 | GenBank | AAN95303.1 | 226 | Sequence 4 from patent US 6468774 |
| GI:6006001 | GenBank | AAV20726.1 | 226 | Sequence 986 from patent US 6753314 |
| GI:6006001 | GenBank | ABW61003.1 | 226 | Sequence 52 from patent US 7279294 |
| GI:6006001 | GenBank | AGU27941.1 | 226 | Sequence 31 from patent US 8497078 |
| GI:6006001 | GenBank | AHD69489.1 | 226 | Sequence 503 from patent US 8586006 |