Gene/Proteome Database (LMPD)

LMPD ID
LMP001195
Gene ID
5950
Species
Homo sapiens (Human)
Gene Name
retinol binding protein 4, plasma
Gene Symbol
RBP4
Synonyms
RDCCAS
Alternate Names
retinol-binding protein 4; RBP; PRBP; plasma retinol-binding protein; retinol-binding protein 4, interstitial
Chromosome
10
Map Location
10q23.33
Summary
This protein belongs to the lipocalin family and is the specific carrier for retinol (vitamin A alcohol) in the blood. It delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin which prevents its loss by filtration through the kidney glomeruli. A deficiency of vitamin A blocks secretion of the binding protein posttranslationally and results in defective delivery and supply to the epidermal cells. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for RBP4

Proteins

retinol-binding protein 4 precursor
Refseq ID NP_006735
Protein GI 55743122
UniProt ID P02753
mRNA ID NM_006744
Length 201
RefSeq Status REVIEWED
MKWVWALLLLAALGSGRAERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL
sig_peptide: 1..18 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1956 peptide sequence: MKWVWALLLLAALGSGRA mat_peptide: 19..201 product: retinol-binding protein 4 calculated_mol_wt: 21072 peptide sequence: ERDCRVSSFRVKENFDKARFSGTWYAMAKKDPEGLFLQDNIVAEFSVDETGQMSATAKGRVRLLNNWDVCADMVGTFTDTEDPAKFKMKYWGVASFLQKGNDDHWIVDTDYDTYAVQYSCRLLNLDGTCADSYSFVFSRDPNGLPPEAQKIVRQRQEELCLARQYRLIVHNGYCDGRSERNLL

Gene Information

Entrez Gene ID
5950
Gene Name
retinol binding protein 4, plasma
Gene Symbol
RBP4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005829 TAS:Reactome C cytosol
GO:0005576 TAS:Reactome C extracellular region
GO:0005615 IDA:BHF-UCL C extracellular space
GO:0070062 IDA:UniProtKB C extracellular vesicular exosome
GO:0043234 IEA:Ensembl C protein complex
GO:0016918 IEA:UniProtKB-KW F retinal binding
GO:0019841 IDA:BHF-UCL F retinol binding
GO:0034632 IC:BHF-UCL F retinol transporter activity
GO:0048738 ISS:BHF-UCL P cardiac muscle tissue development
GO:0050908 IEA:Ensembl P detection of light stimulus involved in visual perception
GO:0048562 ISS:BHF-UCL P embryonic organ morphogenesis
GO:0060059 ISS:BHF-UCL P embryonic retina morphogenesis in camera-type eye
GO:0048706 ISS:BHF-UCL P embryonic skeletal system development
GO:0001654 IMP:BHF-UCL P eye development
GO:0048807 ISS:BHF-UCL P female genitalia morphogenesis
GO:0006094 IMP:BHF-UCL P gluconeogenesis
GO:0042593 IDA:BHF-UCL P glucose homeostasis
GO:0007507 ISS:BHF-UCL P heart development
GO:0060347 ISS:BHF-UCL P heart trabecula formation
GO:0030324 ISS:BHF-UCL P lung development
GO:0030277 IDA:BHF-UCL P maintenance of gastrointestinal epithelium
GO:0008584 IEA:Ensembl P male gonad development
GO:0060044 ISS:BHF-UCL P negative regulation of cardiac muscle cell proliferation
GO:0007603 TAS:Reactome P phototransduction, visible light
GO:0051024 ISS:BHF-UCL P positive regulation of immunoglobulin secretion
GO:0032024 IMP:BHF-UCL P positive regulation of insulin secretion
GO:0045471 IEA:Ensembl P response to ethanol
GO:0032868 IEA:Ensembl P response to insulin
GO:0032526 IDA:BHF-UCL P response to retinoic acid
GO:0042574 IEA:Ensembl P retinal metabolic process
GO:0001523 TAS:Reactome P retinoid metabolic process
GO:0042572 IMP:BHF-UCL P retinol metabolic process
GO:0034633 IC:BHF-UCL P retinol transport
GO:0007283 IEA:Ensembl P spermatogenesis
GO:0060157 ISS:BHF-UCL P urinary bladder development
GO:0060065 ISS:BHF-UCL P uterus development
GO:0060068 ISS:BHF-UCL P vagina development

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_24968 Retinoid metabolism and transport
REACT_160156 The canonical retinoid cycle in rods (twilight vision)

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR002345 Lipocalin
IPR022272 Lipocalin family conserved site
IPR022271 Lipocalin, ApoD type
IPR000566 Lipocalin/cytosolic fatty-acid binding domain
IPR002449 Retinol binding protein/Purpurin

UniProt Annotations

Entry Information

Gene Name
retinol binding protein 4, plasma
Protein Entry
RET4_HUMAN
UniProt ID
P02753
Species
Human

Comments

Comment Type Description
Disease Retinal dystrophy, iris coloboma, and comedogenic acne syndrome (RDCCAS) [MIM
Function Delivers retinol from the liver stores to the peripheral tissues. In plasma, the RBP-retinol complex interacts with transthyretin, this prevents its loss by filtration through the kidney glomeruli.
Interaction O55245:TTR (xeno); NbExp=2; IntAct=EBI-2116134, EBI-7038226;
Mass Spectrometry Mass=20162; Method=MALDI; Range=19-194; Evidence= ;
Mass Spectrometry Mass=20534; Method=MALDI; Range=19-197; Evidence= ;
Mass Spectrometry Mass=21063.46; Mass_error=1.88; Method=Electrospray; Range=17-199; Evidence= ;
Sequence Caution Sequence=AAF69622.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the calycin superfamily. Lipocalin family.
Subcellular Location Secreted.
Web Resource Name=Mutations of the RBP4 gene; Note=Retina International's Scientific Newsletter; URL="http://www.retina-international.org/files/sci-news/rlbp4mut.htm";
Web Resource Name=Wikipedia; Note=Retinol-binding protein 4 entry; URL="http://en.wikipedia.org/wiki/Retinol_binding_protein_4";

Identical and Related Proteins

Unique RefSeq proteins for LMP001195 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
55743122 RefSeq NP_006735 201 retinol-binding protein 4 precursor

Identical Sequences to LMP001195 proteins

Reference Database Accession Length Protein Name
GI:55743122 GenBank AED39039.1 201 Sequence 887 from patent US 7883858
GI:55743122 GenBank JAA12288.1 201 retinol binding protein 4, plasma [Pan troglodytes]
GI:55743122 GenBank AHE01347.1 201 Sequence 56263 from patent US 8586006
GI:55743122 RefSeq XP_008948942.1 201 PREDICTED: retinol-binding protein 4 [Pan paniscus]
GI:55743122 RefSeq XP_009457151.1 201 PREDICTED: retinol-binding protein 4 isoform X1 [Pan troglodytes]
GI:55743122 RefSeq XP_009457152.1 201 PREDICTED: retinol-binding protein 4 isoform X1 [Pan troglodytes]

Related Sequences to LMP001195 proteins

Reference Database Accession Length Protein Name
GI:55743122 GenBank AAH20633.1 201 Retinol binding protein 4, plasma [Homo sapiens]
GI:55743122 RefSeq XP_003904062.1 201 PREDICTED: retinol-binding protein 4 [Papio anubis]
GI:55743122 RefSeq XP_005270080.1 265 PREDICTED: retinol-binding protein 4 isoform X1 [Homo sapiens]
GI:55743122 RefSeq XP_007961780.1 265 PREDICTED: retinol-binding protein 4 isoform X1 [Chlorocebus sabaeus]
GI:55743122 RefSeq XP_007961783.1 201 PREDICTED: retinol-binding protein 4 isoform X2 [Chlorocebus sabaeus]
GI:55743122 RefSeq XP_009213253.1 201 PREDICTED: retinol-binding protein 4 [Papio anubis]