Gene/Proteome Database (LMPD)
LMPD ID
LMP001196
Gene ID
Species
Homo sapiens (Human)
Gene Name
dehydrogenase/reductase (SDR family) member 3
Gene Symbol
Synonyms
DD83.1; RDH17; Rsdr1; SDR1; SDR16C1; retSDR1
Alternate Names
short-chain dehydrogenase/reductase 3; short-chain dehydrogenase/reductase 1; retinal short-chain dehydrogenase/reductase 1; short chain dehydrogenase/reductase family 16C, member 1
Chromosome
1
Map Location
1p36.1
EC Number
1.1.1.300
Summary
Short-chain dehydrogenases/reductases (SDRs), such as DHRS3, catalyze the oxidation/reduction of a wide range of substrates, including retinoids and steroids (Haeseleer and Palczewski, 2000 [PubMed 10800688]).[supplied by OMIM, Jun 2009]
Orthologs
Proteins
| short-chain dehydrogenase/reductase 3 | |
|---|---|
| Refseq ID | NP_004744 |
| Protein GI | 31543615 |
| UniProt ID | O75911 |
| mRNA ID | NM_004753 |
| Length | 302 |
| RefSeq Status | VALIDATED |
| MVWKRLGALVMFPLQMIYLVVKAAVGLVLPAKLRDLSRENVLITGGGRGIGRQLAREFAERGARKIVLWGRTEKCLKETTEEIRQMGTECHYFICDVGNREEVYQTAKAVREKVGDITILVNNAAVVHGKSLMDSDDDALLKSQHINTLGQFWTTKAFLPRMLELQNGHIVCLNSVLALSAIPGAIDYCTSKASAFAFMESLTLGLLDCPGVSATTVLPFHTSTEMFQGMRVRFPNLFPPLKPETVARRTVEAVQLNQALLLLPWTMHALVILKSILPQAALEEIHKFSGTYTCMNTFKGRT | |
Gene Information
Entrez Gene ID
Gene Name
dehydrogenase/reductase (SDR family) member 3
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0042622 | TAS:Reactome | C | photoreceptor outer segment membrane |
| GO:0052650 | IEA:UniProtKB-EC | F | NADP-retinol dehydrogenase activity |
| GO:0009055 | TAS:UniProtKB | F | electron carrier activity |
| GO:0000166 | TAS:ProtInc | F | nucleotide binding |
| GO:0004745 | IEA:Ensembl | F | retinol dehydrogenase activity |
| GO:0060349 | IEA:Ensembl | P | bone morphogenesis |
| GO:0060411 | IEA:Ensembl | P | cardiac septum morphogenesis |
| GO:0048387 | IEA:Ensembl | P | negative regulation of retinoic acid receptor signaling pathway |
| GO:0003151 | IEA:Ensembl | P | outflow tract morphogenesis |
| GO:0060021 | IEA:Ensembl | P | palate development |
| GO:0007603 | TAS:Reactome | P | phototransduction, visible light |
| GO:0030278 | IEA:Ensembl | P | regulation of ossification |
| GO:0001523 | TAS:Reactome | P | retinoid metabolic process |
| GO:0042572 | TAS:UniProtKB | P | retinol metabolic process |
| GO:0007601 | TAS:ProtInc | P | visual perception |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| hsa00830 | Retinol metabolism |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_160083 | The retinoid cycle in cones (daylight vision) |
| REACT_160125 | Visual phototransduction |
Domain Information
UniProt Annotations
Entry Information
Gene Name
dehydrogenase/reductase (SDR family) member 3
Protein Entry
DHRS3_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O75911-1; Sequence=Displayed; Name=2; IsoId=O75911-2; Sequence=VSP_013256, VSP_013257; Note=No experimental confirmation available.; |
| Catalytic Activity | All-trans-retinol + NADP(+) = all-trans- retinal + NADPH. |
| Function | Catalyzes the reduction of all-trans-retinal to all- trans-retinol in the presence of NADPH. |
| Induction | By retinoic acid. |
| Miscellaneous | Located in a region of chromosome 1 which is often deleted in aggressive neuroblastoma tumors. |
| Sequence Caution | Sequence=AAQ88460.1; Type=Frameshift; Positions=15; Evidence= ; |
| Similarity | Belongs to the short-chain dehydrogenases/reductases (SDR) family. |
| Subcellular Location | Membrane ; Multi-pass membrane protein . |
| Tissue Specificity | Widely expressed with highest levels found in heart, placenta, lung, liver, kidney, pancreas, thyroid, testis, stomach, trachea and spinal cord. Lower levels found in skeletal muscle, intestine and lymph node. No expression detected in brain. In the retina, expressed in cone but not rod outer segments. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001196 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31543615 | RefSeq | NP_004744 | 302 | short-chain dehydrogenase/reductase 3 |
Identical Sequences to LMP001196 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31543615 | GenBank | JAA12222.1 | 302 | dehydrogenase/reductase (SDR family) member 3 [Pan troglodytes] |
| GI:31543615 | GenBank | JAA26881.1 | 302 | dehydrogenase/reductase (SDR family) member 3 [Pan troglodytes] |
| GI:31543615 | GenBank | JAA38781.1 | 302 | dehydrogenase/reductase (SDR family) member 3 [Pan troglodytes] |
| GI:31543615 | GenBank | AHD76184.1 | 302 | Sequence 19457 from patent US 8586006 |
| GI:31543615 | GenBank | AIC55549.1 | 302 | DHRS3, partial [synthetic construct] |
| GI:31543615 | RefSeq | XP_004024713.1 | 302 | PREDICTED: short-chain dehydrogenase/reductase 3 [Gorilla gorilla gorilla] |
Related Sequences to LMP001196 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31543615 | DBBJ | BAG35800.1 | 302 | unnamed protein product [Homo sapiens] |
| GI:31543615 | GenBank | AAC63263.1 | 302 | retinal short-chain dehydrogenase/reductase retSDR1 [Homo sapiens] |
| GI:31543615 | GenBank | AAD55402.1 | 302 | short-chain dehydrogenase/reductase 1 [Homo sapiens] |
| GI:31543615 | GenBank | EHH14339.1 | 302 | hypothetical protein EGK_00247 [Macaca mulatta] |
| GI:31543615 | GenBank | EHH49540.1 | 302 | hypothetical protein EGM_00217 [Macaca fascicularis] |
| GI:31543615 | RefSeq | XP_010370030.1 | 302 | PREDICTED: short-chain dehydrogenase/reductase 3 [Rhinopithecus roxellana] |