Gene/Proteome Database (LMPD)

LMPD ID
LMP001204
Gene ID
56075
Species
Mus musculus (Mouse)
Gene Name
prenyl (solanesyl) diphosphate synthase, subunit 1
Gene Symbol
Pdss1
Synonyms
2610203G20Rik; 2700031G06Rik; TPT; TPT 1; Tprt; mDLP1; mSPS1
Alternate Names
decaprenyl-diphosphate synthase subunit 1; trans-prenyltransferase 1; solanesyl-diphosphate synthase subunit 1; decaprenyl pyrophosphate synthase subunit 1; subunit 1 of solanesyl diphosphate synthase; decaprenyl pyrophosphate synthetase subunit 1; all-trans-decaprenyl-diphosphate synthase subunit 1
Chromosome
2
Map Location
2 A3|2
EC Number
2.5.1.91

Proteins

decaprenyl-diphosphate synthase subunit 1
Refseq ID NP_062374
Protein GI 90577181
UniProt ID Q33DR2
mRNA ID NM_019501
Length 409
RefSeq Status VALIDATED
MAMRWSCWRRGCSWRPTAVGSPRRERPGCVEPLGTRAASDTRAQIPYFSLMKILMSASPTMHSISQFHQRTPAMCSCRQTQSGEKYSDPFKLGWRDLKGLYEDIRKELHISTRELKDMSEYYFDGKGKAFRPIIVVLMARACNIHHNNAREMQASQRSIALVAEMIHTATLVHDDVIDDASSRRGKHTVNKIWGEKKAVLAGDLILSAASVALARIGNTAVVSMLAQVIEDLVRGEFLQLGSKENENERFAHYLEKTFKKTASLIANSCKAVSVLGCPDPVVHEIAYQYGKNVGIAFQLIDDVLDFTSCSDQMGKPTSADLKLGIATGPVLFACQQFPEMNAMIMRRFSLPGDVDRARQYVLQSDGVQQTTYLAQQYCHKAVREIRKLRPSTERDALIQLSESVLTRDK

Gene Information

Entrez Gene ID
56075
Gene Name
prenyl (solanesyl) diphosphate synthase, subunit 1
Gene Symbol
Pdss1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005739 IDA:MGI C mitochondrion
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0046982 IDA:HGNC F protein heterodimerization activity
GO:0000010 IEA:Ensembl F trans-hexaprenyltranstransferase activity
GO:0008299 IDA:HGNC P isoprenoid biosynthetic process
GO:0051290 IPI:MGI P protein heterotetramerization
GO:0006744 IDA:HGNC P ubiquinone biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
ko00900 Terpenoid backbone biosynthesis
mmu00900 Terpenoid backbone biosynthesis

REACTOME Pathway Links

REACTOME Pathway ID Description
5892760 Metabolism
5894069 Ubiquinol biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008949 Isoprenoid synthase domain
IPR000092 Polyprenyl synthetase
IPR017446 Polyprenyl synthetase-related

UniProt Annotations

Entry Information

Gene Name
prenyl (solanesyl) diphosphate synthase, subunit 1
Protein Entry
DPS1_MOUSE
UniProt ID
Q33DR2
Species
Mouse

Comments

Comment Type Description
Catalytic Activity (2E,6E)-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate. {ECO:0000269|PubMed:16262699}.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000250}; Note=Binds 3 Mg(2+) ions per subunit. {ECO:0000250};
Function Supplies decaprenyl diphosphate, the precursor for the side chain of the isoprenoid quinones ubiquinone-10. {ECO:0000269|PubMed:16262699}.
Pathway Cofactor biosynthesis; ubiquinone biosynthesis.
Sequence Caution Sequence=AAD24462.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH26820.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the FPP/GGPP synthase family. {ECO:0000305}.
Subcellular Location Mitochondrion {ECO:0000305}.
Subunit Heterotetramer of 2 DPS1/TPRT and 2 DLP1 subunits. {ECO:0000269|PubMed:16262699}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001204 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
90577181 RefSeq NP_062374 409 decaprenyl-diphosphate synthase subunit 1

Identical Sequences to LMP001204 proteins

Reference Database Accession Length Protein Name
GI:90577181 DBBJ BAE48219.1 409 subunit 1 of solanesyl diphosphate synthase [Mus musculus]
GI:90577181 SwissProt Q33DR2.1 409 RecName: Full=Decaprenyl-diphosphate synthase subunit 1; AltName: Full=All-trans-decaprenyl-diphosphate synthase subunit 1; AltName: Full=Decaprenyl pyrophosphate synthase subunit 1; AltName: Full=Solanesyl-diphosphate synthase subunit 1; AltName: Full=Trans-prenyltransferase 1; Short=TPT 1 [Mus musculus]

Related Sequences to LMP001204 proteins

Reference Database Accession Length Protein Name
GI:90577181 GenBank AAI07275.2 385 Pdss1 protein, partial [Mus musculus]
GI:90577181 GenBank EDL83936.1 409 rCG40823, isoform CRA_b [Rattus norvegicus]
GI:90577181 RefSeq XP_002725353.2 500 PREDICTED: decaprenyl-diphosphate synthase subunit 1 isoform X1 [Rattus norvegicus]
GI:90577181 RefSeq XP_003751782.2 500 PREDICTED: decaprenyl-diphosphate synthase subunit 1 isoform X1 [Rattus norvegicus]
GI:90577181 RefSeq XP_008772271.1 513 PREDICTED: decaprenyl-diphosphate synthase subunit 1 isoform X2 [Rattus norvegicus]
GI:90577181 RefSeq XP_008770145.1 513 PREDICTED: decaprenyl-diphosphate synthase subunit 1 isoform X2 [Rattus norvegicus]