Gene/Proteome Database (LMPD)

LMPD ID
LMP001209
Gene ID
11303
Species
Mus musculus (Mouse)
Gene Name
ATP-binding cassette, sub-family A (ABC1), member 1
Gene Symbol
Abca1
Synonyms
ABC-1; Abc1
Alternate Names
ATP-binding cassette sub-family A member 1; ATP-binding cassette 1; ATP-binding cassette transporter 1
Chromosome
4
Map Location
4 A5-B3|4 28.57 cM
Summary
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intracellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ABC1 subfamily. Members of the ABC1 subfamily comprise the only major ABC subfamily found exclusively in multicellular eukaryotes. In humans, this protein functions as a cholesterol efflux pump in the cellular lipid removal pathway. Mutations in the human gene have been associated with Tangier's disease and familial high-density lipoprotein deficiency. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for Abca1

Proteins

ATP-binding cassette sub-family A member 1
Refseq ID NP_038482
Protein GI 90568038
UniProt ID P41233
mRNA ID NM_013454
Length 2261
RefSeq Status VALIDATED
MACWPQLRLLLWKNLTFRRRQTCQLLLEVAWPLFIFLILISVRLSYPPYEQHECHFPNKAMPSAGTLPWVQGIICNANNPCFRYPTPGEAPGVVGNFNKSIVSRLFSDAQRLLLYSQRDTSIKDMHKVLRMLRQIKHPNSNLKLQDFLVDNETFSGFLQHNLSLPRSTVDSLLQANVGLQKVFLQGYQLHLASLCNGSKLEEIIQLGDAEVSALCGLPRKKLDAAERVLRYNMDILKPVVTKLNSTSHLPTQHLAEATTVLLDSLGGLAQELFSTKSWSDMRQEVMFLTNVNSSSSSTQIYQAVSRIVCGHPEGGGLKIKSLNWYEDNNYKALFGGNNTEEDVDTFYDNSTTPYCNDLMKNLESSPLSRIIWKALKPLLVGKILYTPDTPATRQVMAEVNKTFQELAVFHDLEGMWEELSPQIWTFMENSQEMDLVRTLLDSRGNDQFWEQKLDGLDWTAQDIMAFLAKNPEDVQSPNGSVYTWREAFNETNQAIQTISRFMECVNLNKLEPIPTEVRLINKSMELLDERKFWAGIVFTGITPDSVELPHHVKYKIRMDIDNVERTNKIKDGYWDPGPRADPFEDMRYVWGGFAYLQDVVEQAIIRVLTGSEKKTGVYVQQMPYPCYVDDIFLRVMSRSMPLFMTLAWIYSVAVIIKSIVYEKEARLKETMRIMGLDNGILWFSWFVSSLIPLLVSAGLLVVILKLGNLLPYSDPSVVFVFLSVFAMVTILQCFLISTLFSRANLAAACGGIIYFTLYLPYVLCVAWQDYVGFSIKIFASLLSPVAFGFGCEYFALFEEQGIGVQWDNLFESPVEEDGFNLTTAVSMMLFDTFLYGVMTWYIEAVFPGQYGIPRPWYFPCTKSYWFGEEIDEKSHPGSSQKGVSEICMEEEPTHLRLGVSIQNLVKVYRDGMKVAVDGLALNFYEGQITSFLGHNGAGKTTTMSILTGLFPPTSGTAYILGKDIRSEMSSIRQNLGVCPQHNVLFDMLTVEEHIWFYARLKGLSEKHVKAEMEQMALDVGLPPSKLKSKTSQLSGGMQRKLSVALAFVGGSKVVILDEPTAGVDPYSRRGIWELLLKYRQGRTIILSTHHMDEADILGDRIAIISHGKLCCVGSSLFLKNQLGTGYYLTLVKKDVESSLSSCRNSSSTVSCLKKEDSVSQSSSDAGLGSDHESDTLTIDVSAISNLIRKHVSEARLVEDIGHELTYVLPYEAAKEGAFVELFHEIDDRLSDLGISSYGISETTLEEIFLKVAEESGVDAETSDGTLPARRNRRAFGDKQSCLHPFTEDDAVDPNDSDIDPESRETDLLSGMDGKGSYQLKGWKLTQQQFVALLWKRLLIARRSRKGFFAQIVLPAVFVCIALVFSLIVPPFGKYPSLELQPWMYNEQYTFVSNDAPEDMGTQELLNALTKDPGFGTRCMEGNPIPDTPCLAGEEDWTISPVPQSIVDLFQNGNWTMKNPSPACQCSSDKIKKMLPVCPPGAGGLPPPQRKQKTADILQNLTGRNISDYLVKTYVQIIAKSLKNKIWVNEFRYGGFSLGVSNSQALPPSHEVNDAIKQMKKLLKLTKDSSADRFLSSLGRFMAGLDTKNNVKVWFNNKGWHAISSFLNVINNAILRANLQKGENPSQYGITAFNHPLNLTKQQLSEVALMTTSVDVLVSICVIFAMSFVPASFVVFLIQERVSKAKHLQFISGVKPVIYWLSNFVWDMCNYVVPATLVIIIFICFQQKSYVSSTNLPVLALLLLLYGWSITPLMYPASFVFKIPSTAYVVLTSVNLFIGINGSVATFVLELFTNNKLNDINDILKSVFLIFPHFCLGRGLIDMVKNQAMADALERFGENRFVSPLSWDLVGRNLFAMAVEGVVFFLITVLIQYRFFIRPRPVKAKLPPLNDEDEDVRRERQRILDGGGQNDILEIKELTKIYRRKRKPAVDRICIGIPPGECFGLLGVNGAGKSTTFKMLTGDTPVTRGDAFLNKNSILSNIHEVHQNMGYCPQFDAITELLTGREHVEFFALLRGVPEKEVGKVGEWAIRKLGLVKYGEKYASNYSGGNKRKLSTAMALIGGPPVVFLDEPTTGMDPKARRFLWNCALSIVKEGRSVVLTSHSMEECEALCTRMAIMVNGRFRCLGSVQHLKNRFGDGYTIVVRIAGSNPDLKPVQEFFGLAFPGSVLKEKHRNMLQYQLPSSLSSLARIFSILSQSKKRLHIEDYSVSQTTLDQVFVNFAKDQSDDDHLKDLSLHKNQTVVDVAVLTSFLQDEKVKESYV

Gene Information

Entrez Gene ID
11303
Gene Name
ATP-binding cassette, sub-family A (ABC1), member 1
Gene Symbol
Abca1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005794 IDA:MGI C Golgi apparatus
GO:0009897 IDA:MGI C external side of plasma membrane
GO:0005887 IDA:MGI C integral component of plasma membrane
GO:0043231 IDA:MGI C intracellular membrane-bounded organelle
GO:0045121 IEA:Ensembl C membrane raft
GO:0048471 IEA:Ensembl C perinuclear region of cytoplasm
GO:0045335 IEA:Ensembl C phagocytic vesicle
GO:0005886 IDA:MGI C plasma membrane
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0016887 IEA:InterPro F ATPase activity
GO:0008509 IDA:BHF-UCL F anion transmembrane transporter activity
GO:0034188 IEA:Ensembl F apolipoprotein A-I receptor activity
GO:0017127 IDA:MGI F cholesterol transporter activity
GO:0005548 IDA:MGI F phospholipid transporter activity
GO:0007186 IEA:Ensembl P G-protein coupled receptor signaling pathway
GO:0071397 IEA:Ensembl P cellular response to cholesterol
GO:0071222 IDA:UniProtKB P cellular response to lipopolysaccharide
GO:0071300 IDA:UniProtKB P cellular response to retinoic acid
GO:0033344 IDA:MGI P cholesterol efflux
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0008203 IDA:MGI P cholesterol metabolic process
GO:0016197 IEA:Ensembl P endosomal transport
GO:0034380 IEA:Ensembl P high-density lipoprotein particle assembly
GO:0050702 IEA:Ensembl P interleukin-1 beta secretion
GO:0032367 IEA:Ensembl P intracellular cholesterol transport
GO:0042158 IMP:MGI P lipoprotein biosynthetic process
GO:0042157 IMP:MGI P lipoprotein metabolic process
GO:0007040 IEA:Ensembl P lysosome organization
GO:0002790 IMP:MGI P peptide secretion
GO:0006911 IMP:MGI P phagocytosis, engulfment
GO:0033700 IDA:MGI P phospholipid efflux
GO:0055091 IEA:Ensembl P phospholipid homeostasis
GO:0045332 IMP:MGI P phospholipid translocation
GO:0060155 IEA:Ensembl P platelet dense granule organization
GO:0030819 IEA:Ensembl P positive regulation of cAMP biosynthetic process
GO:0010875 IMP:BHF-UCL P positive regulation of cholesterol efflux
GO:0006497 IMP:MGI P protein lipidation
GO:0032489 IEA:Ensembl P regulation of Cdc42 protein signal transduction
GO:0042493 IEA:Ensembl P response to drug
GO:0034616 IEA:Ensembl P response to laminar fluid shear stress
GO:0055098 IEA:Ensembl P response to low-density lipoprotein particle
GO:0007584 IEA:Ensembl P response to nutrient
GO:0043691 IMP:BHF-UCL P reverse cholesterol transport

KEGG Pathway Links

KEGG Pathway ID Description
mmu02010 ABC transporters
mmu04975 Fat digestion and absorption

Domain Information

InterPro Annotations

Accession Description
IPR003593 AAA+ ATPase domain
IPR026082 ABC transporter A, ABCA
IPR017871 ABC transporter, conserved site
IPR003439 ABC_transporter-like
IPR027417 P-loop containing nucleoside triphosphate hydrolase

UniProt Annotations

Entry Information

Gene Name
ATP-binding cassette, sub-family A (ABC1), member 1
Protein Entry
ABCA1_MOUSE
UniProt ID
P41233
Species
Mouse

Comments

Comment Type Description
Domain Multifunctional polypeptide with two homologous halves, each containing a hydrophobic membrane-anchoring domain and an ATP binding cassette (ABC) domain.
Function cAMP-dependent and sulfonylurea-sensitive anion transporter. Key gatekeeper influencing intracellular cholesterol transport (By similarity). {ECO:0000250}.
Induction Down-regulated by endotoxins (LPS) or cytokines (TNF and IL-1) in J774 macrophages. The down-regulation by endotoxin in macrophages is not likely to be mediated by the liver X receptor/retinoic X receptor (LXR/RXR). {ECO:0000269|PubMed:12032171}.
Ptm Palmitoylation by DHHC8 is essential for membrane localization. {ECO:0000250}.
Ptm Phosphorylation on Ser-2054 regulates phospholipid efflux. {ECO:0000250}.
Sequence Caution Sequence=AAG39073.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA53530.1; Type=Erroneous initiation; Evidence={ECO:0000305};
Similarity Belongs to the ABC transporter superfamily. ABCA family. {ECO:0000305}.
Similarity Contains 2 ABC transporter domains. {ECO:0000255|PROSITE-ProRule:PRU00434}.
Subcellular Location Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Subunit Interacts with MEGF10. {ECO:0000269|PubMed:17205124}.
Tissue Specificity Widely expressed in adult tissues. Highest levels are found in pregnant uterus and uterus.

Identical and Related Proteins

Unique RefSeq proteins for LMP001209 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
90568038 RefSeq NP_038482 2261 ATP-binding cassette sub-family A member 1

Identical Sequences to LMP001209 proteins

Reference Database Accession Length Protein Name
GI:90568038 GenBank EDL02285.1 2261 ATP-binding cassette, sub-family A (ABC1), member 1, isoform CRA_a [Mus musculus]
GI:90568038 GenBank AAI72713.1 2261 ATP-binding cassette, sub-family A (ABC1), member 1 [synthetic construct]
GI:90568038 GenBank AAI56411.1 2261 ATP-binding cassette, sub-family A (ABC1), member 1, partial [synthetic construct]
GI:90568038 SwissProt P41233.4 2261 RecName: Full=ATP-binding cassette sub-family A member 1; AltName: Full=ATP-binding cassette transporter 1; Short=ABC-1; Short=ATP-binding cassette 1 [Mus musculus]

Related Sequences to LMP001209 proteins

Reference Database Accession Length Protein Name
GI:90568038 GenBank AAT23866.1 2261 Sequence 118 from patent US 6713300
GI:90568038 GenBank ABL56231.1 2261 Sequence 118 from patent US 7141420
GI:90568038 GenBank ABP15714.1 2261 Sequence 118 from patent US 7189511
GI:90568038 GenBank ABP23443.1 2261 Sequence 118 from patent US 7192579
GI:90568038 GenBank AFD49308.1 2261 Sequence 118 from patent US 8129353
GI:90568038 RefSeq XP_006537618.1 2263 PREDICTED: ATP-binding cassette sub-family A member 1 isoform X2 [Mus musculus]