Gene/Proteome Database (LMPD)

LMPD ID
LMP001211
Gene ID
83875
Species
Homo sapiens (Human)
Gene Name
beta-carotene oxygenase 2
Gene Symbol
BCO2
Synonyms
B-DIOX-II; BCDO2
Chromosome
11
Map Location
11q23.1
EC Number
1.13.11.71
Summary
This gene encodes an enzyme which oxidizes carotenoids such as beta-carotene during the biosynthesis of vitamin A. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]
Orthologs
View orthologs and multiple alignments for BCO2

Proteins

beta,beta-carotene 9',10'-oxygenase isoform a
Refseq ID NP_114144
Protein GI 374081849
UniProt ID B2RCV8
mRNA ID NM_031938
Length 506
RefSeq Status REVIEWED
MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTTVEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLNAPEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHFFYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITPNQNESNFLLVLDAKNFEELGRAEVPVQMPYGFHGTFIPI
beta,beta-carotene 9',10'-oxygenase isoform b
Refseq ID NP_001032367
Protein GI 374081845
UniProt ID Q9BYV7
mRNA ID NM_001037290
Length 545
RefSeq Status REVIEWED
MGNTPQKKAVFGQCRGLPCVAPLLTTVEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAAMTDNTNVNYVRYKGDYYLCTETNFMNKVDIETLEKTEKVDWSKFIAVNGATAHPHYDPDGTAYNMGNSFGPYGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLNAPEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHFFYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITPNQNESNFLLVLDAKNFEELGRAEVPVQMPYGFHGTFIPI
beta,beta-carotene 9',10'-oxygenase isoform c
Refseq ID NP_001243326
Protein GI 374081847
UniProt ID Q9BYV7
mRNA ID NM_001256397
Length 539
RefSeq Status REVIEWED
MGNTPQKKAVFGQCRGLPCVAPLLTTVEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAAMTDNTNVNYVRYKGDYYLCTETNFMNKVDIETLEKTEKVDWSKFIAVNGATAHPHYDPDGTAYNMGNSFGPYGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLNAPEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHFFYGCGFRHLVGDSLIKVDVVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITPNQNESNFLLVLDAKNFEELGRAEVPVQMPYGFHGTFIPI
beta,beta-carotene 9',10'-oxygenase isoform d
Refseq ID NP_001243327
Protein GI 374081849
UniProt ID Q9BYV7
mRNA ID NM_001256398
Length 506
RefSeq Status REVIEWED
MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTTVEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLNAPEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHFFYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITPNQNESNFLLVLDAKNFEELGRAEVPVQMPYGFHGTFIPI
beta,beta-carotene 9',10'-oxygenase isoform e
Refseq ID NP_001243329
Protein GI 374081849
UniProt ID Q9BYV7
mRNA ID NM_001256400
Length 506
RefSeq Status REVIEWED
MFFRVFLHFIRSHSATAVDFLPVMVHRLPVFKRYMGNTPQKKAVFGQCRGLPCVAPLLTTVEEAPRGISARVWGHFPKWLNGSLLRIGPGKFEFGKDKYNHWFDGMALLHQFRMAKGTVTYRSKFLQSDTYKANSAKNRIVISEFGTLALPDPCKNVFERFMSRFELPGKAAGFSYKVIRVPPEKVDLGETIHGVQVICSIASTEKGKPSYYHSFGMTRNYIIFIEQPLKMNLWKIATSKIRGKAFSDGISWEPQCNTRFHVVEKRTGQLLPGRYYSKPFVTFHQINAFEDQGCVIIDLCCQDNGRTLEVYQLQNLRKAGEGLDQVHNSAAKSFPRRFVLPLNVSLNAPEGDNLSPLSYTSASAVKQADGTIWCSHENLHQEDLEKEGGIEFPQIYYDRFSGKKYHFFYGCGFRHLVGDSLIKVDVVNKTLKVWREDGFYPSEPVFVPAPGTNEEDGGVILSVVITPNQNESNFLLVLDAKNFEELGRAEVPVQMPYGFHGTFIPI

Gene Information

Entrez Gene ID
83875
Gene Name
beta-carotene oxygenase 2
Gene Symbol
BCO2
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005622 IC:UniProtKB C intracellular
GO:0005739 ISS:BHF-UCL C mitochondrion
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0016702 IDA:UniProtKB F oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0016121 IDA:BHF-UCL P carotene catabolic process
GO:0016119 IDA:UniProtKB P carotene metabolic process
GO:0016116 ISS:BHF-UCL P carotenoid metabolic process
GO:0055114 IDA:BHF-UCL P oxidation-reduction process
GO:0051881 ISS:BHF-UCL P regulation of mitochondrial membrane potential
GO:2000377 ISS:BHF-UCL P regulation of reactive oxygen species metabolic process
GO:0042574 NAS:UniProtKB P retinal metabolic process
GO:0042573 NAS:UniProtKB P retinoic acid metabolic process

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160102 Diseases associated with visual transduction
REACT_24968 Retinoid metabolism and transport
REACT_160125 Visual phototransduction

Domain Information

InterPro Annotations

Accession Description
IPR004294 Carotenoid oxygenase

UniProt Annotations

Entry Information

Gene Name
beta-carotene oxygenase 2
Protein Entry
BCDO2_HUMAN
UniProt ID
Q9BYV7
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=5; Name=1; IsoId=Q9BYV7-1; Sequence=Displayed; Name=2; IsoId=Q9BYV7-2; Sequence=VSP_008599; Note=No experimental confirmation available.; Name=4; IsoId=Q9BYV7-4; Sequence=VSP_008599, VSP_008600; Note=No experimental confirmation available.; Name=5; IsoId=Q9BYV7-5; Sequence=VSP_046916; Note=No experimental confirmation available.; Name=6; IsoId=Q9BYV7-6; Sequence=VSP_046915; Note=No experimental confirmation available.;
Catalytic Activity All-trans-beta-carotene + O(2) = all-trans- 10'-apo-beta-carotenal + beta-ionone.
Cofactor Name=Fe(2+); Xref=ChEBI
Function Asymmetrically cleaves beta-carotene at the 9',10' double bond resulting in the formation of beta-apo-10'-carotenal and beta-ionone. Besides beta-carotene, lycopene is also oxidatively cleaved. The apocarotenals formed by this enzyme may be the precursors for the biosynthesis of retinoic acid or exert unknown physiological effects.
Sequence Caution Sequence=CAC27994.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence= ;
Similarity Belongs to the carotenoid oxygenase family.
Subcellular Location Mitochondrion .
Tissue Specificity Highly expressed in retinal pigment epithelium. Also expressed in stomach, small intestine, liver, testis, kidney, adrenal gland, pancreas, heart, skeletal muscle and prostate (at protein level).

Identical and Related Proteins

Unique RefSeq proteins for LMP001211 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
374081849 RefSeq NP_114144 506 beta,beta-carotene 9',10'-oxygenase isoform a
374081845 RefSeq NP_001032367 545 beta,beta-carotene 9',10'-oxygenase isoform b
374081847 RefSeq NP_001243326 539 beta,beta-carotene 9',10'-oxygenase isoform c
374081849 RefSeq NP_001243327 506 beta,beta-carotene 9',10'-oxygenase isoform d
374081849 RefSeq NP_001243329 506 beta,beta-carotene 9',10'-oxygenase isoform e

Identical Sequences to LMP001211 proteins

Reference Database Accession Length Protein Name
GI:374081847 DBBJ BAB55379.1 539 unnamed protein product [Homo sapiens]
GI:374081847 EMBL CAE89890.1 539 unnamed protein product [Homo sapiens]
GI:374081845 GenBank AAK69433.1 545 putative carotene dioxygenase [Homo sapiens]
GI:374081849 GenBank AAH41656.2 506 BCO2 protein [Homo sapiens]
GI:374081849 GenBank AAH41656.2 506 BCO2 protein [Homo sapiens]
GI:374081849 GenBank AAH41656.2 506 BCO2 protein [Homo sapiens]
GI:374081849 GenBank EAW67192.1 506 beta-carotene dioxygenase 2, isoform CRA_d [Homo sapiens]
GI:374081849 GenBank EAW67192.1 506 beta-carotene dioxygenase 2, isoform CRA_d [Homo sapiens]
GI:374081849 GenBank EAW67192.1 506 beta-carotene dioxygenase 2, isoform CRA_d [Homo sapiens]

Related Sequences to LMP001211 proteins

Reference Database Accession Length Protein Name
GI:374081845 DBBJ BAG37705.1 556 unnamed protein product [Homo sapiens]
GI:374081847 DBBJ BAG37705.1 556 unnamed protein product [Homo sapiens]
GI:374081847 GenBank AAK69433.1 545 putative carotene dioxygenase [Homo sapiens]
GI:374081845 GenBank EAW67189.1 579 beta-carotene dioxygenase 2, isoform CRA_a [Homo sapiens]
GI:374081847 GenBank EAW67189.1 579 beta-carotene dioxygenase 2, isoform CRA_a [Homo sapiens]
GI:374081847 GenBank EAW67193.1 539 beta-carotene dioxygenase 2, isoform CRA_e [Homo sapiens]
GI:374081845 GenBank EAW67194.1 545 beta-carotene dioxygenase 2, isoform CRA_f [Homo sapiens]
GI:374081847 GenBank EAW67194.1 545 beta-carotene dioxygenase 2, isoform CRA_f [Homo sapiens]
GI:374081849 GenBank ACA05950.1 483 beta,beta-carotene 9',10'-dioxygenase variant 3 [Homo sapiens]
GI:374081849 GenBank ACA05950.1 483 beta,beta-carotene 9',10'-dioxygenase variant 3 [Homo sapiens]
GI:374081849 GenBank ACA05950.1 483 beta,beta-carotene 9',10'-dioxygenase variant 3 [Homo sapiens]
GI:374081845 GenBank ACA05951.1 556 beta,beta-carotene 9',10'-dioxygenase variant 2 [Homo sapiens]
GI:374081845 GenBank ACA05952.1 579 beta,beta-carotene 9',10'-dioxygenase variant 1 [Homo sapiens]
GI:374081847 RefSeq NP_001032367.2 545 beta,beta-carotene 9',10'-oxygenase isoform b [Homo sapiens]
GI:374081849 RefSeq XP_003794795.1 505 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform 2 [Otolemur garnettii]
GI:374081849 RefSeq XP_003794795.1 505 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform 2 [Otolemur garnettii]
GI:374081849 RefSeq XP_003794795.1 505 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform 2 [Otolemur garnettii]
GI:374081849 RefSeq XP_005579697.1 508 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X5 [Macaca fascicularis]
GI:374081849 RefSeq XP_005579697.1 508 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X5 [Macaca fascicularis]
GI:374081849 RefSeq XP_005579697.1 508 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X5 [Macaca fascicularis]
GI:374081849 RefSeq XP_005667395.1 514 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X8 [Sus scrofa]
GI:374081849 RefSeq XP_005667395.1 514 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X8 [Sus scrofa]
GI:374081849 RefSeq XP_005667395.1 514 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X8 [Sus scrofa]
GI:374081849 RefSeq XP_008063761.1 512 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X3 [Tarsius syrichta]
GI:374081849 RefSeq XP_008063761.1 512 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X3 [Tarsius syrichta]
GI:374081849 RefSeq XP_008063761.1 512 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X3 [Tarsius syrichta]
GI:374081849 RefSeq XP_010332863.1 532 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X2 [Saimiri boliviensis boliviensis]
GI:374081849 RefSeq XP_010332863.1 532 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X2 [Saimiri boliviensis boliviensis]
GI:374081849 RefSeq XP_010332863.1 532 PREDICTED: beta,beta-carotene 9',10'-oxygenase isoform X2 [Saimiri boliviensis boliviensis]
GI:374081845 SwissProt Q9BYV7.5 579 RecName: Full=Beta,beta-carotene 9',10'-oxygenase; AltName: Full=B-diox-II; AltName: Full=Beta-carotene dioxygenase 2 [Homo sapiens]