Gene/Proteome Database (LMPD)

LMPD ID
LMP001222
Gene ID
7941
Species
Homo sapiens (Human)
Gene Name
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Gene Symbol
PLA2G7
Synonyms
LDL-PLA2; LP-PLA2; PAFAD; PAFAH
Alternate Names
platelet-activating factor acetylhydrolase; LDL-PLA(2); gVIIA-PLA2; PAF 2-acylhydrolase; PAF acetylhydrolase; group-VIIA phospholipase A2; LDL-associated phospholipase A2; lipoprotein-associated phospholipase A2; 1-alkyl-2-acetylglycerophosphocholine esterase; 2-acetyl-1-alkylglycerophosphocholine esterase
Chromosome
6
Map Location
6p21.2-p12
EC Number
3.1.1.47
Summary
The protein encoded by this gene is a secreted enzyme that catalyzes the degradation of platelet-activating factor to biologically inactive products. Defects in this gene are a cause of platelet-activating factor acetylhydrolase deficiency. Two transcript variants encoding the same protein have been found for this gene.[provided by RefSeq, Dec 2009]
Orthologs
View orthologs and multiple alignments for PLA2G7

Proteins

platelet-activating factor acetylhydrolase precursor
Refseq ID NP_005075
Protein GI 189095271
UniProt ID Q13093
mRNA ID NM_005084
Length 441
RefSeq Status REVIEWED
MVPPKLHVLFCLCGCLAVVYPFDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN
sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2303 peptide sequence: MVPPKLHVLFCLCGCLAVVYP mat_peptide: 22..441 product: platelet-activating factor acetylhydrolase calculated_mol_wt: 47793 peptide sequence: FDWQYINPVAHMKSSAWVNKIQVLMAAASFGQTKIPRGNGPYSVGCTDLMFDHTNKGTFLRLYYPSQDNDRLDTLWIPNKEYFWGLSKFLGTHWLMGNILRLLFGSMTTPANWNSPLRPGEKYPLVVFSHGLGAFRTLYSAIGIDLASHGFIVAAVEHRDRSASATYYFKDQSAAEIGDKSWLYLRTLKQEEETHIRNEQVRQRAKECSQALSLILDIDHGKPVKNALDLKFDMEQLKDSIDREKIAVIGHSFGGATVIQTLSEDQRFRCGIALDAWMFPLGDEVYSRIPQPLFFINSEYFQYPANIIKMKKCYSPDKERKMITIRGSVHQNFADFTFATGKIIGHMLKLKGDIDSNVAIDLSNKASLAFLQKHLGLHKDFDQWDCLIEGDDENLIPGTNINTTNQHIMLQNSSGIEKYN sig_peptide: 1..21 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2303 peptide sequence: MVPPKLHVLFCLCGCLAVVYP
platelet-activating factor acetylhydrolase precursor
Refseq ID NP_001161829
Protein GI 270133071
UniProt ID Q13093
mRNA ID NM_001168357
Length 441
RefSeq Status REVIEWED
Protein sequence is identical to GI:189095271 (mRNA isoform)

Gene Information

Entrez Gene ID
7941
Gene Name
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Gene Symbol
PLA2G7
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:Ensembl C cytoplasm
GO:0005576 TAS:Reactome C extracellular region
GO:0034362 IDA:BHF-UCL C low-density lipoprotein particle
GO:0003847 IEA:UniProtKB-EC F 1-alkyl-2-acetylglycerophosphocholine esterase activity
GO:0047499 IDA:BHF-UCL F calcium-independent phospholipase A2 activity
GO:0005543 IDA:BHF-UCL F phospholipid binding
GO:0044267 TAS:Reactome P cellular protein metabolic process
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0034440 IDA:BHF-UCL P lipid oxidation
GO:0034374 IDA:BHF-UCL P low-density lipoprotein particle remodeling
GO:0034441 IDA:BHF-UCL P plasma lipoprotein particle oxidation
GO:0050729 TAS:BHF-UCL P positive regulation of inflammatory response
GO:0090026 IDA:BHF-UCL P positive regulation of monocyte chemotaxis

KEGG Pathway Links

KEGG Pathway ID Description
hsa00565 Ether lipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_160078 Peptide hormone metabolism
REACT_19189 Synthesis, secretion, and deacylation of Ghrelin

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR005065 Platelet-activating factor acetylhydrolase
IPR016715 Platelet-activating factor acetylhydrolase, eucaryote

UniProt Annotations

Entry Information

Gene Name
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
Protein Entry
PAFA_HUMAN
UniProt ID
Q13093
Species
Human

Comments

Comment Type Description
Catalytic Activity 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine + H(2)O = 1-alkyl-sn-glycero-3-phosphocholine + acetate.
Disease Asthma (ASTHMA) [MIM
Disease Atopic hypersensitivity (ATOPY) [MIM
Disease Platelet-activating factor acetylhydrolase deficiency (PAFAD) [MIM
Function Modulates the action of platelet-activating factor (PAF) by hydrolyzing the sn-2 ester bond to yield the biologically inactive lyso-PAF. Has a specificity for substrates with a short residue at the sn-2 position. It is inactive against long-chain phospholipids.
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Subcellular Location Secreted, extracellular space.
Tissue Specificity Plasma.
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pla2g7/";

Identical and Related Proteins

Unique RefSeq proteins for LMP001222 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
189095271 RefSeq NP_005075 441 platelet-activating factor acetylhydrolase precursor

Identical Sequences to LMP001222 proteins

Reference Database Accession Length Protein Name
GI:189095271 GenBank AEP61510.1 441 Sequence 23 from patent US 8026209
GI:189095271 GenBank AEU43315.1 441 Sequence 64 from patent US 8052970
GI:189095271 GenBank AEU43326.1 441 Sequence 75 from patent US 8052970
GI:189095271 GenBank AFQ78652.1 441 Sequence 1 from patent US 8241849
GI:189095271 GenBank AHE15990.1 441 Sequence 23 from patent US 8613929
GI:189095271 RefSeq XP_005249465.1 441 PREDICTED: platelet-activating factor acetylhydrolase isoform X1 [Homo sapiens]

Related Sequences to LMP001222 proteins

Reference Database Accession Length Protein Name
GI:189095271 EMBL CAA02638.1 441 unnamed protein product, partial [unidentified]
GI:189095271 GenBank ABQ01234.1 441 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma) [Homo sapiens]
GI:189095271 GenBank ABZ24361.1 441 Sequence 14 from patent US 7314742
GI:189095271 GenBank ADQ33028.1 441 phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma), partial [synthetic construct]
GI:189095271 GenBank AHD75939.1 441 Sequence 18322 from patent US 8586006
GI:189095271 GenBank AIC55359.1 441 PLA2G7, partial [synthetic construct]