Gene/Proteome Database (LMPD)
LMPD ID
LMP001228
Gene ID
Species
Homo sapiens (Human)
Gene Name
group-specific component (vitamin D binding protein)
Gene Symbol
Synonyms
DBP; DBP/GC; GRD3; HEL-S-51; VDBG; VDBP
Alternate Names
vitamin D-binding protein; VDB; gc-globulin; vitamin D-binding alpha-globulin; epididymis secretory protein Li 51
Chromosome
4
Map Location
4q12-q13
Summary
The protein encoded by this gene belongs to the albumin gene family. It is a multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid and on the surface of many cell types. It binds to vitamin D and its plasma metabolites and transports them to target tissues. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Orthologs
Proteins
| vitamin D-binding protein isoform 1 precursor | |
|---|---|
| Refseq ID | NP_001191235 |
| Protein GI | 324021743 |
| UniProt ID | P02774 |
| mRNA ID | NM_001204306 |
| Length | 474 |
| RefSeq Status | REVIEWED |
| MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL | |
| vitamin D-binding protein isoform 1 precursor | |
|---|---|
| Refseq ID | NP_000574 |
| Protein GI | 32483410 |
| UniProt ID | P02774 |
| mRNA ID | NM_000583 |
| Length | 474 |
| RefSeq Status | REVIEWED |
| Protein sequence is identical to GI:324021743 (mRNA isoform) | |
| vitamin D-binding protein isoform 3 precursor | |
|---|---|
| Refseq ID | NP_001191236 |
| Protein GI | 324021743 |
| UniProt ID | P02774 |
| mRNA ID | NM_001204307 |
| Length | 474 |
| RefSeq Status | REVIEWED |
| MKRVLVLLLAVAFGHALERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL | |
| sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1738 peptide sequence: MKRVLVLLLAVAFGHA mat_peptide: 17..474 product: Vitamin D-binding protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02774.1) calculated_mol_wt: 51198 peptide sequence: LERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL sig_peptide: 1..16 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 1738 peptide sequence: MKRVLVLLLAVAFGHA mat_peptide: 17..474 product: Vitamin D-binding protein experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (P02774.1) calculated_mol_wt: 51198 peptide sequence: LERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL sig_peptide: 1..35 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 3898 peptide sequence: MLWSWSEERGGAARLSGRKMKRVLVLLLAVAFGHA mat_peptide: 36..493 product: vitamin D-binding protein isoform 3 calculated_mol_wt: 51198 peptide sequence: LERGRDYEKNKVCKEFSHLGKEDFTSLSLVLYSRKFPSGTFEQVSQLVKEVVSLTEACCAEGADPDCYDTRTSALSAKSCESNSPFPVHPGTAECCTKEGLERKLCMAALKHQPQEFPTYVEPTNDEICEAFRKDPKEYANQFMWEYSTNYGQAPLSLLVSYTKSYLSMVGSCCTSASPTVCFLKERLQLKHLSLLTTLSNRVCSQYAAYGEKKSRLSNLIKLAQKVPTADLEDVLPLAEDITNILSKCCESASEDCMAKELPEHTVKLCDNLSTKNSKFEDCCQEKTAMDVFVCTYFMPAAQLPELPDVELPTNKDVCDPGNTKVMDKYTFELSRRTHLPEVFLSKVLEPTLKSLGECCDVEDSTTCFNAKGPLLKKELSSFIDKGQELCADYSENTFTEYKKKLAERLKAKLPDATPTELAKLVNKHSDFASNCCSINSPPLYCDSEIDAELKNIL | |
Gene Information
Entrez Gene ID
Gene Name
group-specific component (vitamin D binding protein)
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0072562 | IDA:UniProt | C | blood microparticle |
| GO:0005829 | TAS:Reactome | C | cytosol |
| GO:0005576 | NAS:UniProtKB | C | extracellular region |
| GO:0005615 | IDA:UniProt | C | extracellular space |
| GO:0070062 | IDA:UniProtKB | C | extracellular vesicular exosome |
| GO:0043202 | TAS:Reactome | C | lysosomal lumen |
| GO:0003779 | IPI:UniProtKB | F | actin binding |
| GO:1902118 | IDA:UniProtKB | F | calcidiol binding |
| GO:0005499 | TAS:ProtInc | F | vitamin D binding |
| GO:0051183 | IEA:InterPro | F | vitamin transporter activity |
| GO:0044281 | TAS:Reactome | P | small molecule metabolic process |
| GO:0008202 | TAS:Reactome | P | steroid metabolic process |
| GO:0042359 | TAS:Reactome | P | vitamin D metabolic process |
| GO:0051180 | TAS:ProtInc | P | vitamin transport |
REACTOME Pathway Links
| REACTOME Pathway ID | Description |
|---|---|
| REACT_111217 | Metabolism |
| REACT_11057 | Metabolism of steroid hormones and vitamin D |
| REACT_13523 | Vitamin D (calciferol) metabolism |
Domain Information
UniProt Annotations
Entry Information
Gene Name
group-specific component (vitamin D binding protein)
Protein Entry
VTDB_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=P02774-1; Sequence=Displayed; Name=2; IsoId=P02774-2; Sequence=VSP_038427; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.; Name=3; IsoId=P02774-3; Sequence=VSP_044523; Note=No experimental confirmation available.; |
| Function | Multifunctional protein found in plasma, ascitic fluid, cerebrospinal fluid, and urine and on the surface of many cell types. In plasma, it carries the vitamin D sterols and prevents polymerization of actin by binding its monomers. DBP associates with membrane-bound immunoglobulin on the surface of B-lymphocytes and with IgG Fc receptor on the membranes of T-lymphocytes. |
| Polymorphism | Over 80 variants of human DBP have been identified. The three most common alleles are called GC*1F, GC*1S, and GC*2. The sequence shown is that of the GC*2 allele. |
| Sequence Caution | Sequence=BAG60654.1; Type=Erroneous translation; Note=Wrong choice of CDS.; Evidence= ; |
| Similarity | Belongs to the ALB/AFP/VDB family. |
| Similarity | Contains 3 albumin domains. {ECO |
| Subcellular Location | Secreted. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001228 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 324021743 | RefSeq | NP_001191235 | 474 | vitamin D-binding protein isoform 1 precursor |
| 324021743 | RefSeq | NP_001191236 | 474 | vitamin D-binding protein isoform 3 precursor |
Identical Sequences to LMP001228 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:324021743 | GenBank | ACR85574.1 | 474 | Sequence 133 from patent US 7521195 |
| GI:324021743 | GenBank | ACR85574.1 | 474 | Sequence 133 from patent US 7521195 |
| GI:324021743 | GenBank | ADS58854.1 | 474 | Sequence 5 from patent US 7807392 |
| GI:324021743 | GenBank | ADS58854.1 | 474 | Sequence 5 from patent US 7807392 |
| GI:324021743 | GenBank | ADT51100.1 | 474 | Sequence 3117 from patent US 7842467 |
| GI:324021743 | GenBank | ADT51100.1 | 474 | Sequence 3117 from patent US 7842467 |
| GI:324021743 | GenBank | AEQ43827.1 | 474 | Sequence 25 from patent US 8034773 |
| GI:324021743 | GenBank | AEQ43827.1 | 474 | Sequence 25 from patent US 8034773 |
| GI:324021743 | GenBank | AHE01212.1 | 474 | Sequence 56128 from patent US 8586006 |
| GI:324021743 | GenBank | AHE01212.1 | 474 | Sequence 56128 from patent US 8586006 |
| GI:324021743 | RefSeq | NP_000574.2 | 474 | vitamin D-binding protein isoform 1 precursor [Homo sapiens] |
| GI:324021743 | RefSeq | NP_000574.2 | 474 | vitamin D-binding protein isoform 1 precursor [Homo sapiens] |
Related Sequences to LMP001228 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:324021743 | DBBJ | BAF83516.1 | 474 | unnamed protein product [Homo sapiens] |
| GI:324021743 | DBBJ | BAF83516.1 | 474 | unnamed protein product [Homo sapiens] |
| GI:324021743 | DBBJ | BAF98744.1 | 474 | unnamed protein product [Homo sapiens] |
| GI:324021743 | DBBJ | BAF98744.1 | 474 | unnamed protein product [Homo sapiens] |
| GI:324021743 | GenBank | AAH57228.1 | 474 | Group-specific component (vitamin D binding protein) [Homo sapiens] |
| GI:324021743 | GenBank | AAH57228.1 | 474 | Group-specific component (vitamin D binding protein) [Homo sapiens] |
| GI:324021743 | GenBank | AIC54443.1 | 474 | GC, partial [synthetic construct] |
| GI:324021743 | GenBank | AIC54443.1 | 474 | GC, partial [synthetic construct] |
| GI:324021743 | RefSeq | NP_001191236.1 | 493 | vitamin D-binding protein isoform 3 precursor [Homo sapiens] |
| GI:324021743 | RefSeq | NP_001191236.1 | 493 | vitamin D-binding protein isoform 3 precursor [Homo sapiens] |
| GI:324021743 | RefSeq | XP_004038844.1 | 474 | PREDICTED: vitamin D-binding protein isoform 2 [Gorilla gorilla gorilla] |
| GI:324021743 | RefSeq | XP_004038844.1 | 474 | PREDICTED: vitamin D-binding protein isoform 2 [Gorilla gorilla gorilla] |