Gene/Proteome Database (LMPD)

LMPD ID
LMP001248
Gene ID
2167
Species
Homo sapiens (Human)
Gene Name
fatty acid binding protein 4, adipocyte
Gene Symbol
FABP4
Synonyms
A-FABP; AFABP; ALBP; HEL-S-104; aP2
Chromosome
8
Map Location
8q21
Summary
FABP4 encodes the fatty acid binding protein found in adipocytes. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for FABP4

Proteins

fatty acid-binding protein, adipocyte
Refseq ID NP_001433
Protein GI 4557579
UniProt ID P15090
mRNA ID NM_001442
Length 132
RefSeq Status REVIEWED
MCDAFVGTWKLVSSENFDDYMKEVGVGFATRKVAGMAKPNMIISVNGDVITIKSESTFKNTEISFILGQEFDEVTADDRKVKSTITLDGGVLVHVQKWDGKSTTIKRKREDDKLVVECVMKGVTSTRVYERA

Gene Information

Entrez Gene ID
2167
Gene Name
fatty acid binding protein 4, adipocyte
Gene Symbol
FABP4
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IDA:HPA C cytoplasm
GO:0008289 IEA:UniProtKB-KW F lipid binding
GO:0005215 IEA:InterPro F transporter activity
GO:0050873 IEA:Ensembl P brown fat cell differentiation
GO:0071285 IEA:Ensembl P cellular response to lithium ion
GO:0042632 IEA:Ensembl P cholesterol homeostasis
GO:0001816 IEA:Ensembl P cytokine production
GO:0006469 IEA:Ensembl P negative regulation of protein kinase activity
GO:0045892 IEA:Ensembl P negative regulation of transcription, DNA-templated
GO:0050729 IEA:Ensembl P positive regulation of inflammatory response
GO:0050872 IEA:Ensembl P white fat cell differentiation

KEGG Pathway Links

KEGG Pathway ID Description
hsa03320 PPAR signaling pathway
ko03320 PPAR signaling pathway

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_494 Hormone-sensitive lipase (HSL)-mediated triacylglycerol hydrolysis
REACT_27161 Transcriptional regulation of white adipocyte differentiation

Domain Information

InterPro Annotations

Accession Description
IPR012674 Calycin
IPR011038 Calycin-like
IPR000463 Cytosolic fatty-acid binding
IPR000566 Lipocalin/cytosolic fatty-acid binding domain

UniProt Annotations

Entry Information

Gene Name
fatty acid binding protein 4, adipocyte
Protein Entry
FABP4_HUMAN
UniProt ID
P15090
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001248 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
4557579 RefSeq NP_001433 132 fatty acid-binding protein, adipocyte

Identical Sequences to LMP001248 proteins

Reference Database Accession Length Protein Name
GI:4557579 GenBank ADU05469.1 132 fatty acid binding protein 4, adipocyte [Homo sapiens]
GI:4557579 GenBank ADZ16076.1 132 fatty acid binding protein 4, adipocyte, partial [synthetic construct]
GI:4557579 GenBank AHD75465.1 132 Sequence 17228 from patent US 8586006
GI:4557579 GenBank AIC48729.1 132 FABP4, partial [synthetic construct]
GI:4557579 RefSeq XP_003831316.1 132 PREDICTED: fatty acid-binding protein, adipocyte [Pan paniscus]
GI:4557579 RefSeq XP_004047248.1 132 PREDICTED: fatty acid-binding protein, adipocyte [Gorilla gorilla gorilla]

Related Sequences to LMP001248 proteins

Reference Database Accession Length Protein Name
GI:4557579 GenBank AAP36447.1 133 Homo sapiens fatty acid binding protein 4, adipocyte, partial [synthetic construct]
GI:4557579 GenBank AAX29478.1 133 fatty acid binding protein 4 adipocyte, partial [synthetic construct]
GI:4557579 GenBank AAX29479.1 133 fatty acid binding protein 4 adipocyte, partial [synthetic construct]
GI:4557579 GenBank ACM81913.1 136 Sequence 7411 from patent US 6812339
GI:4557579 PDB 2HNX 136 Chain A, Crystal Structure Of Ap2
GI:4557579 PDB 3P6D 139 Chain A, Human Adipocyte Lipid-Binding Protein Fabp4 In Complex With 3-(4- Methoxy-3-Methylphenyl) Propionic Acid