Gene/Proteome Database (LMPD)

LMPD ID
LMP001251
Gene ID
2710
Species
Homo sapiens (Human)
Gene Name
glycerol kinase
Gene Symbol
GK
Synonyms
GK1; GKD
Chromosome
X
Map Location
Xp21.3
Summary
The protein encoded by this gene belongs to the FGGY kinase family. This protein is a key enzyme in the regulation of glycerol uptake and metabolism. It catalyzes the phosphorylation of glycerol by ATP, yielding ADP and glycerol-3-phosphate. Mutations in this gene are associated with glycerol kinase deficiency (GKD). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011]
Orthologs
View orthologs and multiple alignments for GK

Proteins

glycerol kinase isoform a
Refseq ID NP_976325
Protein GI 42794763
UniProt ID P32189
mRNA ID NM_203391
Length 530
RefSeq Status REVIEWED
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGIP
glycerol kinase isoform b
Refseq ID NP_000158
Protein GI 4504007
UniProt ID P32189
mRNA ID NM_000167
Length 524
RefSeq Status REVIEWED
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGIP
glycerol kinase isoform c
Refseq ID NP_001121599
Protein GI 189409120
UniProt ID P32189
mRNA ID NM_001128127
Length 553
RefSeq Status REVIEWED
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLMKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP
glycerol kinase isoform d
Refseq ID NP_001191948
Protein GI 326381123
UniProt ID P32189
mRNA ID NM_001205019
Length 559
RefSeq Status REVIEWED
MAASKKAVLGPLVGAVDQGTSSTRFLVFNSKTAELLSHHQVEIKQEFPREGWVEQDPKEILHSVYECIEKTCEKLGQLNIDISNIKAIGVSNQRETTVVWDKITGEPLYNAVVWLDLRTQSTVESLSKRIPGNNNFVKSKTGLPLSTYFSAVKLRWLLDNVRKVQKAVEEKRALFGTIDSWLIWSLTGGVNGGVHCTDVTNASRTMLFNIHSLEWDKQLCEFFGIPMEILPNVRSSSEIYGLMKISHSVKAGALEGVPISGCLGDQSAALVGQMCFQIGQAKNTYGTGCFLLCNTGHKCVFSDHGLLTTVAYKLGRDKPVYYALEGSVAIAGAVIRWLRDNLGIIKTSEEIEKLAKEVGTSYGCYFVPAFSGLYAPYWEPSARGIICGLTQFTNKCHIAFAALEAVCFQTREILDAMNRDCGIPLSHLQVDGGMTSNKILMQLQADILYIPVVKPSMPETTALGAAMAAGAAEGVGVWSLEPEDLSAVTMERFEPQINAEESEIRYSTWKKAVMKSMGWVTTQSPESGDPSIFCSLPLGFFIVSSMVMLIGARYISGIP

Gene Information

Entrez Gene ID
2710
Gene Name
glycerol kinase
Gene Symbol
GK
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0016301 IEA:UniProtKB-KW F kinase activity
GO:0016773 IEA:InterPro F phosphotransferase activity, alcohol group as acceptor
GO:0005975 IEA:InterPro P carbohydrate metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00561 Glycerolipid metabolism
hsa03320 PPAR signaling pathway

Domain Information

InterPro Annotations

Accession Description
IPR018485 Carbohydrate kinase, FGGY, C-terminal
IPR018484 Carbohydrate kinase, FGGY, N-terminal
IPR018483 Carbohydrate kinase, FGGY, conserved site

UniProt Annotations

Entry Information

Gene Name
glycerol kinase
Protein Entry
GLPK_HUMAN
UniProt ID
P32189
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001251 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42794763 RefSeq NP_976325 530 glycerol kinase isoform a
4504007 RefSeq NP_000158 524 glycerol kinase isoform b
189409120 RefSeq NP_001121599 553 glycerol kinase isoform c
326381123 RefSeq NP_001191948 559 glycerol kinase isoform d

Identical Sequences to LMP001251 proteins

Reference Database Accession Length Protein Name
GI:326381123 EMBL CAB54859.1 559 glycerol kinase [Homo sapiens]
GI:42794763 EMBL CBV16771.1 530 unnamed protein product [Homo sapiens]
GI:42794763 EMBL CBV23462.1 530 unnamed protein product [Homo sapiens]
GI:326381123 GenBank JAA05349.1 559 glycerol kinase [Pan troglodytes]
GI:189409120 GenBank JAA16759.1 553 glycerol kinase [Pan troglodytes]
GI:326381123 GenBank JAA16760.1 559 glycerol kinase [Pan troglodytes]
GI:4504007 GenBank JAA16761.1 524 glycerol kinase [Pan troglodytes]
GI:189409120 GenBank JAA29195.1 553 glycerol kinase [Pan troglodytes]
GI:326381123 GenBank JAA39481.1 559 glycerol kinase [Pan troglodytes]
GI:42794763 GenBank AGX94616.1 530 Sequence 69501 from patent US 8541208
GI:42794763 GenBank AGY01483.1 530 Sequence 83180 from patent US 8541208
GI:4504007 GenBank AHD75729.1 524 Sequence 18112 from patent US 8586006
GI:42794763 GenBank AHD75730.1 530 Sequence 18113 from patent US 8586006
GI:189409120 RefSeq XP_003261228.1 553 PREDICTED: glycerol kinase isoform 1 [Nomascus leucogenys]
GI:4504007 RefSeq XP_003261229.1 524 PREDICTED: glycerol kinase isoform 2 [Nomascus leucogenys]
GI:4504007 RefSeq XP_003317451.1 524 PREDICTED: glycerol kinase isoform X8 [Pan troglodytes]
GI:189409120 RefSeq XP_003317452.1 553 PREDICTED: glycerol kinase isoform X6 [Pan troglodytes]
GI:42794763 RefSeq XP_003317453.1 530 PREDICTED: glycerol kinase isoform X7 [Pan troglodytes]
GI:326381123 RefSeq XP_003317454.1 559 PREDICTED: glycerol kinase isoform X4 [Pan troglodytes]
GI:4504007 RefSeq XP_004064001.1 524 PREDICTED: putative glycerol kinase 3 [Gorilla gorilla gorilla]
GI:189409120 RefSeq XP_005593291.1 553 PREDICTED: glycerol kinase isoform X5 [Macaca fascicularis]
GI:189409120 RefSeq XP_007989546.1 553 PREDICTED: glycerol kinase isoform X7 [Chlorocebus sabaeus]
GI:4504007 RefSeq XP_007989548.1 524 PREDICTED: glycerol kinase isoform X9 [Chlorocebus sabaeus]
GI:326381123 SwissProt P32189.3 559 RecName: Full=Glycerol kinase; Short=GK; Short=Glycerokinase; AltName: Full=ATP:glycerol 3-phosphotransferase [Homo sapiens]

Related Sequences to LMP001251 proteins

Reference Database Accession Length Protein Name
GI:4504007 GenBank AAQ02574.1 525 glycerol kinase, partial [synthetic construct]
GI:326381123 GenBank AFE77752.1 559 glycerol kinase isoform d [Macaca mulatta]
GI:189409120 GenBank JAA16760.1 559 glycerol kinase [Pan troglodytes]
GI:42794763 GenBank JAA16760.1 559 glycerol kinase [Pan troglodytes]
GI:4504007 GenBank JAA29195.1 553 glycerol kinase [Pan troglodytes]
GI:42794763 GenBank JAA39481.1 559 glycerol kinase [Pan troglodytes]
GI:4504007 RefSeq NP_001121599.1 553 glycerol kinase isoform c [Homo sapiens]
GI:42794763 RefSeq XP_003261230.1 530 PREDICTED: glycerol kinase isoform 3 [Nomascus leucogenys]
GI:326381123 RefSeq XP_003261231.1 559 PREDICTED: glycerol kinase isoform 4 [Nomascus leucogenys]
GI:189409120 RefSeq XP_003917588.1 551 PREDICTED: glycerol kinase isoform X4 [Papio anubis]
GI:189409120 RefSeq XP_003924116.1 553 PREDICTED: glycerol kinase isoform X2 [Saimiri boliviensis boliviensis]
GI:326381123 RefSeq XP_005593289.1 559 PREDICTED: glycerol kinase isoform X3 [Macaca fascicularis]
GI:4504007 RefSeq XP_005593291.1 553 PREDICTED: glycerol kinase isoform X5 [Macaca fascicularis]
GI:326381123 RefSeq XP_007989543.1 559 PREDICTED: glycerol kinase isoform X4 [Chlorocebus sabaeus]
GI:42794763 RefSeq XP_007989547.1 530 PREDICTED: glycerol kinase isoform X8 [Chlorocebus sabaeus]
GI:326381123 RefSeq XP_009232963.1 559 PREDICTED: glycerol kinase isoform X1 [Pongo abelii]
GI:189409120 RefSeq XP_009232964.1 553 PREDICTED: glycerol kinase isoform X2 [Pongo abelii]
GI:4504007 RefSeq XP_009232965.1 524 PREDICTED: glycerol kinase isoform X3 [Pongo abelii]
GI:326381123 RefSeq XP_010356466.1 559 PREDICTED: glycerol kinase isoform X1 [Rhinopithecus roxellana]
GI:189409120 RefSeq XP_010356468.1 553 PREDICTED: glycerol kinase isoform X3 [Rhinopithecus roxellana]
GI:189409120 RefSeq XP_010356469.1 551 PREDICTED: glycerol kinase isoform X4 [Rhinopithecus roxellana]
GI:42794763 RefSeq XP_010356470.1 530 PREDICTED: glycerol kinase isoform X5 [Rhinopithecus roxellana]
GI:4504007 RefSeq XP_010356471.1 524 PREDICTED: glycerol kinase isoform X6 [Rhinopithecus roxellana]
GI:42794763 SwissProt P32189.3 559 RecName: Full=Glycerol kinase; Short=GK; Short=Glycerokinase; AltName: Full=ATP:glycerol 3-phosphotransferase [Homo sapiens]