Gene/Proteome Database (LMPD)
LMPD ID
LMP001257
Gene ID
Species
Mus musculus (Mouse)
Gene Name
UDP galactosyltransferase 8A
Gene Symbol
Synonyms
AI850488; AW455908; Cgt; Ugt8; mCerGT
Alternate Names
2-hydroxyacylsphingosine 1-beta-galactosyltransferase; cerebroside synthase; UDP-glucuronosyltransferase 8; ceramide UDP-galactosyltransferase; UDP-galactose-ceramide galactosyltransferase 8A
Chromosome
3
Map Location
3|3 E3-F1
EC Number
2.4.1.45
Proteins
| 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor | |
|---|---|
| Refseq ID | NP_035804 |
| Protein GI | 31543926 |
| UniProt ID | Q64676 |
| mRNA ID | NM_011674 |
| Length | 541 |
| RefSeq Status | PROVISIONAL |
| MKSYTPYFMLLWSAVGIARAAKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSYVTKFIYRKIKSLWSKNEHSTVNGHYQNGIRNGKYKGNGRVKHEKKVR | |
| sig_peptide: 1..20 inference: non-experimental evidence, no additional details recorded note: Potential; propagated from UniProtKB/Swiss-Prot (Q64676.2) calculated_mol_wt: 2306 peptide sequence: MKSYTPYFMLLWSAVGIARA mat_peptide: 21..541 product: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase experiment: experimental evidence, no additional details recorded note: propagated from UniProtKB/Swiss-Prot (Q64676.2) calculated_mol_wt: 58962 peptide sequence: AKIIIVPPIMFESHLYIFKTLASALHERGHHTVLLLSEGRDIAPSNHYSLQRYPGIFNSTTSDAFLQSKMRNIFSGRLTAVELVDILDHYTKNCDMMVGNQALIQGLKKEKFDLLLVDPNDMCGFVIAHLLGVKYAVFSTGLWYPAEVGAPAPLAYVPEFNSLLTDRMNFLERMKNTGVYLISRIGVSFLVLPKYERIMQKYNLLPAKSMYDLVHGSSLWMLCTDVALEFPRPTLPNVVYVGGILTKPASPLPEDLQRWVSGAQEHGFVLVSFGAGVKYLSEDIANKLAGALGRLPQKVIWRFSGTKPKNLGNNTKLIEWLPQNDLLGHSNIRAFLSHGGLNSIFETMYHGVPVVGIPLFGDHYDTMTRVQAKGMGILLEWNTVTEGELYDALVKVINNPSYRQRAQKLSEIHKDQPGHPVNRTTYWIDYILRHDGARHLRSAVHQISFCQYFLLDIAFVLLLGAVLLYFILSYVTKFIYRKIKSLWSKNEHSTVNGHYQNGIRNGKYKGNGRVKHEKKVR | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0003851 | IEA:UniProtKB-EC | F | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity |
| GO:0008489 | IEA:Ensembl | F | UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity |
| GO:0008120 | TAS:MGI | F | ceramide glucosyltransferase activity |
| GO:0008088 | IMP:BHF-UCL | P | axon cargo transport |
| GO:0007010 | IMP:BHF-UCL | P | cytoskeleton organization |
| GO:0006682 | IEA:UniProtKB-UniPathway | P | galactosylceramide biosynthetic process |
| GO:0009247 | TAS:MGI | P | glycolipid biosynthetic process |
| GO:0042552 | TAS:MGI | P | myelination |
| GO:0048812 | IMP:BHF-UCL | P | neuron projection morphogenesis |
| GO:0030913 | IMP:BHF-UCL | P | paranodal junction assembly |
| GO:0002175 | IMP:BHF-UCL | P | protein localization to paranode region of axon |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR002213 | UDP-glucuronosyl/UDP-glucosyltransferase |
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | UDP-alpha-D-galactose + 2-(2- hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2- hydroxyacyl)sphingosine. |
| Function | Catalyzes the transfer of galactose to ceramide, a key enzymatic step in the biosynthesis of galactocerebrosides, which are abundant sphingolipids of the myelin membrane of the central nervous system and peripheral nervous system. |
| Pathway | Sphingolipid metabolism; galactosylceramide biosynthesis. |
| Similarity | Belongs to the UDP-glycosyltransferase family. {ECO:0000305}. |
| Subcellular Location | Membrane {ECO:0000305}; Single-pass membrane protein {ECO:0000305}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001257 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31543926 | RefSeq | NP_035804 | 541 | 2-hydroxyacylsphingosine 1-beta-galactosyltransferase precursor |
Identical Sequences to LMP001257 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31543926 | DBBJ | BAE23325.1 | 541 | unnamed protein product [Mus musculus] |
| GI:31543926 | GenBank | AAH16885.1 | 541 | Ugt8a protein [Mus musculus] |
| GI:31543926 | RefSeq | XP_006501373.1 | 541 | PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X2 [Mus musculus] |
| GI:31543926 | SwissProt | Q64676.2 | 541 | RecName: Full=2-hydroxyacylsphingosine 1-beta-galactosyltransferase; AltName: Full=Ceramide UDP-galactosyltransferase; AltName: Full=Cerebroside synthase; AltName: Full=UDP-galactose-ceramide galactosyltransferase; Flags: Precursor [Mus musculus] |
Related Sequences to LMP001257 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31543926 | EMBL | CAA63090.1 | 541 | UDP-galactose ceramide galactosyltransferase [Mus musculus] |
| GI:31543926 | EMBL | CAA63091.1 | 541 | UDP-galactose ceramide galactosyltransferase [Mus musculus] |
| GI:31543926 | GenBank | AAA16108.1 | 541 | ceramide UDP-galactosyltransferase [Rattus norvegicus] |
| GI:31543926 | GenBank | AAC53576.1 | 541 | UDP-galactose:ceramide galactosyltransferase [Mus musculus] |
| GI:31543926 | GenBank | EDL12286.1 | 541 | UDP galactosyltransferase 8A [Mus musculus] |
| GI:31543926 | RefSeq | XP_006501372.1 | 555 | PREDICTED: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase isoform X1 [Mus musculus] |