Gene/Proteome Database (LMPD)

LMPD ID
LMP001258
Gene ID
55512
Species
Homo sapiens (Human)
Gene Name
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Gene Symbol
SMPD3
Synonyms
NSMASE2
Chromosome
16
Map Location
16q22.1

Proteins

sphingomyelin phosphodiesterase 3
Refseq ID NP_061137
Protein GI 8923946
UniProt ID Q9NY59
mRNA ID NM_018667
Length 655
RefSeq Status VALIDATED
MVLYTTPFPNSCLSALHCVSWALIFPCYWLVDRLAASFIPTTYEKRQRADDPCCLQLLCTALFTPIYLALLVASLPFAFLGFLFWSPLQSARRPYIYSRLEDKGLAGGAALLSEWKGTGPGKSFCFATANVCLLPDSLARVNNLFNTQARAKEIGQRIRNGAARPQIKIYIDSPTNTSISAASFSSLVSPQGGDGVARAVPGSIKRTASVEYKGDGGRHPGDEAANGPASGDPVDSSSPEDACIVRIGGEEGGRPPEADDPVPGGQARNGAGGGPRGQTPNHNQQDGDSGSLGSPSASRESLVKGRAGPDTSASGEPGANSKLLYKASVVKKAAARRRRHPDEAFDHEVSAFFPANLDFLCLQEVFDKRAATKLKEQLHGYFEYILYDVGVYGCQGCCSFKCLNSGLLFASRYPIMDVAYHCYPNKCNDDALASKGALFLKVQVGSTPQDQRIVGYIACTHLHAPQEDSAIRCGQLDLLQDWLADFRKSTSSSSAANPEELVAFDVVCGDFNFDNCSSDDKLEQQHSLFTHYRDPCRLGPGEEKPWAIGTLLDTNGLYDEDVCTPDNLQKVLESEEGRREYLAFPTSKSSGQKGRKELLKGNGRRIDYMLHAEEGLCPDWKAEVEEFSFITQLSGLTDHLPVAMRLMVSSGEEEA

Gene Information

Entrez Gene ID
55512
Gene Name
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Gene Symbol
SMPD3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000137 IEA:Ensembl C Golgi cis cisterna
GO:0005886 TAS:Reactome C plasma membrane
GO:0046872 IEA:UniProtKB-KW F metal ion binding
GO:0004767 IEA:UniProtKB-EC F sphingomyelin phosphodiesterase activity
GO:0007049 IEA:UniProtKB-KW P cell cycle
GO:0006687 TAS:Reactome P glycosphingolipid metabolic process
GO:0002244 IEA:Ensembl P hematopoietic progenitor cell differentiation
GO:0030072 IEA:Ensembl P peptide hormone secretion
GO:0044281 TAS:Reactome P small molecule metabolic process
GO:0006665 TAS:Reactome P sphingolipid metabolic process
GO:0006685 TAS:ProtInc P sphingomyelin catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa01100 Metabolic pathways
hsa00600 Sphingolipid metabolism
ko00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11281 sphingomyelin metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_116105 Glycosphingolipid metabolism
REACT_111217 Metabolism
REACT_22258 Metabolism of lipids and lipoproteins
REACT_19323 Sphingolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR005135 Endonuclease/exonuclease/phosphatase

UniProt Annotations

Entry Information

Gene Name
sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II)
Protein Entry
NSMA2_HUMAN
UniProt ID
Q9NY59
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NY59-1; Sequence=Displayed; Name=2; IsoId=Q9NY59-2; Sequence=VSP_054334; Note=No experimental confirmation available.;
Biophysicochemical Properties pH dependence: Optimum pH is 7.5.;
Catalytic Activity Sphingomyelin + H(2)O = N-acylsphingosine + phosphocholine.
Cofactor Name=Mg(2+); Xref=ChEBI:CHEBI:18420; Evidence={ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:15051724};
Developmental Stage Up-regulated during G0/G1 phases.
Enzyme Regulation Activated by unsaturated fatty acids and phosphatidylserine. {ECO:0000269|PubMed:10823942}.
Function Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization. {ECO:0000269|PubMed:10823942, ECO:0000269|PubMed:14741383, ECO:0000269|PubMed:15051724}.
Pathway Lipid metabolism; sphingolipid metabolism.
Ptm Palmitoylated, palmitoylation-deficient proteins are targeted for lysosomal degradation. {ECO:0000250}.
Similarity Belongs to the neutral sphingomyelinase family. {ECO:0000305}.
Subcellular Location Golgi apparatus membrane; Lipid-anchor. Cell membrane; Lipid-anchor. Note=May localize to detergent-resistant subdomains of Golgi membranes of hypothalamic neurosecretory neurons. According to PubMed:15051724, it localizes to plasma membrane in confluent contact-inhibited cells.
Tissue Specificity Predominantly expressed in brain. {ECO:0000269|PubMed:10823942}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001258 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
8923946 RefSeq NP_061137 655 sphingomyelin phosphodiesterase 3

Identical Sequences to LMP001258 proteins

Reference Database Accession Length Protein Name
GI:8923946 EMBL CCF76927.1 655 unnamed protein product [Homo sapiens]
GI:8923946 GenBank ADR83107.1 655 sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II), partial [synthetic construct]
GI:8923946 GenBank AIC51789.1 655 SMPD3, partial [synthetic construct]
GI:8923946 RefSeq XP_005256088.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Homo sapiens]
GI:8923946 RefSeq XP_005256089.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 isoform X2 [Homo sapiens]
GI:8923946 RefSeq XP_006721293.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 isoform X3 [Homo sapiens]

Related Sequences to LMP001258 proteins

Reference Database Accession Length Protein Name
GI:8923946 DBBJ BAF82340.1 655 unnamed protein product [Homo sapiens]
GI:8923946 RefSeq XP_003814620.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 [Pan paniscus]
GI:8923946 RefSeq XP_009429370.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Pan troglodytes]
GI:8923946 RefSeq XP_009429372.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Pan troglodytes]
GI:8923946 RefSeq XP_009429373.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Pan troglodytes]
GI:8923946 RefSeq XP_009429374.1 655 PREDICTED: sphingomyelin phosphodiesterase 3 isoform X1 [Pan troglodytes]