Gene/Proteome Database (LMPD)

LMPD ID
LMP001264
Gene ID
26423
Species
Mus musculus (Mouse)
Gene Name
nuclear receptor subfamily 5, group A, member 1
Gene Symbol
Nr5a1
Synonyms
Ad4BP; ELP; ELP-3; Ftz-F1; Ftzf1; SF-1; SF1
Alternate Names
steroidogenic factor 1; STF-1; adrenal 4-binding protein; embryonal LTR-binding protein; fushi tarazu 1 factor homolog; fushi tarazu factor homolog 1; steroid hormone receptor Ad4BP; steroid hydroxylase positive regulator; embryonal long terminal repeat-binding protein
Chromosome
2
Map Location
2 B|2 24.42 cM

Proteins

steroidogenic factor 1
Refseq ID NP_620639
Protein GI 20522231
UniProt ID P33242
mRNA ID NM_139051
Length 462
RefSeq Status VALIDATED
MDYSYDEDLDELCPVCGDKVSGYHYGLLTCESCKGFFKRTVQNNKHYTCTESQSCKIDKTQRKRCPFCRFQKCLTVGMRLEAVRADRMRGGRNKFGPMYKRDRALKQQKKAQIRANGFKLETGPPMGVPPPPPPPPDYMLPPSLHAPEPKALVSGPPSGPLGDFGAPSLPMAVPGPHGPLAGYLYPAFSNRTIKSEYPEPYASPPQQPGPPYSYPEPFSGGPNVPELILQLLQLEPEEDQVRARIVGCLQEPAKSRSDQPAPFSLLCRMADQTFISIVDWARRCMVFKELEVADQMTLLQNCWSELLVLDHIYRQVQYGKEDSILLVTGQEVELSTVAVQAGSLLHSLVLRAQELVLQLHALQLDRQEFVCLKFLILFSLDVKFLNNHSLVKDAQEKANAALLDYTLCHYPHCGDKFQQLLLCLVEVRALSMQAKEYLYHKHLGNEMPRNNLLIEMLQAKQT

Gene Information

Entrez Gene ID
26423
Gene Name
nuclear receptor subfamily 5, group A, member 1
Gene Symbol
Nr5a1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005634 IDA:HGNC C nucleus
GO:0003677 IDA:MGI F DNA binding
GO:0003705 IEA:Ensembl F RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0003682 IDA:MGI F chromatin binding
GO:0003690 IEA:Ensembl F double-stranded DNA binding
GO:0005543 IEA:Ensembl F phospholipid binding
GO:0043565 IEA:Ensembl F sequence-specific DNA binding
GO:0003707 IEA:InterPro F steroid hormone receptor activity
GO:0008270 IEA:InterPro F zinc ion binding
GO:0030325 IMP:MGI P adrenal gland development
GO:0030154 IGI:MGI P cell differentiation
GO:0042445 IMP:MGI P hormone metabolic process
GO:0001553 IMP:MGI P luteinization
GO:0051457 IDA:MGI P maintenance of protein location in nucleus
GO:0008584 IMP:MGI P male gonad development
GO:0010259 IMP:MGI P multicellular organismal aging
GO:2000195 IMP:UniProtKB P negative regulation of female gonad development
GO:2000020 IMP:UniProtKB P positive regulation of male gonad development
GO:0045944 IDA:MGI P positive regulation of transcription from RNA polymerase II promoter
GO:0045893 IMP:UniProtKB P positive regulation of transcription, DNA-templated
GO:0006357 IDA:MGI P regulation of transcription from RNA polymerase II promoter
GO:0006355 IDA:MGI P regulation of transcription, DNA-templated
GO:0022414 IMP:MGI P reproductive process
GO:0009888 IMP:MGI P tissue development

REACTOME Pathway Links

REACTOME Pathway ID Description
5893658 Nuclear Receptor transcription pathway

Domain Information

InterPro Annotations

Accession Description
IPR008946 Nuclear hormone receptor, ligand-binding
IPR000536 Nuclear hormone receptor, ligand-binding, core
IPR001723 Steroid hormone receptor
IPR016355 Steroidogenic_factor_1
IPR013088 Zinc finger, NHR/GATA-type
IPR001628 Zinc finger, nuclear hormone receptor-type

UniProt Annotations

Entry Information

Gene Name
nuclear receptor subfamily 5, group A, member 1
Protein Entry
STF1_MOUSE
UniProt ID
P33242
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P33242-1; Sequence=Displayed; Name=2; IsoId=P33242-2; Sequence=VSP_003715;
Developmental Stage Expressed during early embryonic development. Expressed only in undifferentiated embryonal carcinoma cells.
Function Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO- NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity (By similarity). Transcription repressor of the Moloney leukemia virus long terminal repeat in undifferentiated murine embryonal carcinoma cells. Binds phosphatidylcholine and phospholipids with a phosphatidylinositol (PI) headgroup, in particular phosphatidyl(3,4)bisphosphate, phosphatidyl(3,5)bisphosphate and phosphatidyl(3,4,5)triphosphate. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation. {ECO:0000250, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:18988706}.
Ptm Acetylation stimulates the transcriptional activity. {ECO:0000250}.
Ptm Phosphorylated on Ser-203 by CDK7. This phosphorylation promotes transcriptional activity (By similarity). {ECO:0000250}.
Ptm Sumoylation reduces CDK7-mediated phosophorylation on Ser- 203. {ECO:0000250}.
Sequence Caution Sequence=BAA01441.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Similarity Belongs to the nuclear hormone receptor family. NR5 subfamily. {ECO:0000305}.
Similarity Contains 1 nuclear receptor DNA-binding domain. {ECO:0000255|PROSITE-ProRule:PRU00407}.
Subcellular Location Nucleus.
Subunit Binds DNA as a monomer (By similarity). Part of a complex consisting of SFPQ, NONO and NR5A1. Interacts with DGKQ and CDK7 (By similarity). Interacts with NR0B2, NCOA2 and PPARGC1A. Binds to and activated by HIPK3. {ECO:0000250, ECO:0000269|PubMed:15707893, ECO:0000269|PubMed:15721253, ECO:0000269|PubMed:17210646, ECO:0000269|PubMed:18988706, ECO:0000269|PubMed:8395013}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001264 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
20522231 RefSeq NP_620639 462 steroidogenic factor 1

Identical Sequences to LMP001264 proteins

Reference Database Accession Length Protein Name
GI:20522231 DBBJ BAE22121.1 462 unnamed protein product [Mus musculus]
GI:20522231 DBBJ BAE25855.1 462 unnamed protein product [Mus musculus]
GI:20522231 GenBank AAI10477.1 462 Nuclear receptor subfamily 5, group A, member 1 [Mus musculus]
GI:20522231 GenBank AAI10478.1 462 Nuclear receptor subfamily 5, group A, member 1 [Mus musculus]
GI:20522231 RefSeq XP_006498125.1 462 PREDICTED: steroidogenic factor 1 isoform X7 [Mus musculus]
GI:20522231 SwissProt P33242.3 462 RecName: Full=Steroidogenic factor 1; Short=SF-1; Short=STF-1; AltName: Full=Adrenal 4-binding protein; AltName: Full=Embryonal LTR-binding protein; Short=ELP; AltName: Full=Embryonal long terminal repeat-binding protein; AltName: Full=Fushi tarazu factor homolog 1; AltName: Full=Nuclear receptor subfamily 5 group A member 1; AltName: Full=Steroid hormone receptor Ad4BP; AltName: Full=Steroid hydroxylase positive regulator [Mus musculus]

Related Sequences to LMP001264 proteins

Reference Database Accession Length Protein Name
GI:20522231 DBBJ BAA07722.1 462 Ad4BP [Rattus norvegicus]
GI:20522231 DBBJ BAE33893.1 462 unnamed protein product [Mus musculus]
GI:20522231 GenBank EDL26824.1 462 nuclear receptor subfamily 5, group A, member 1, isoform CRA_b [Mus musculus]
GI:20522231 GenBank EDM00510.1 462 rCG37716, isoform CRA_a [Rattus norvegicus]
GI:20522231 RefSeq NP_001178028.1 462 steroidogenic factor 1 [Rattus norvegicus]
GI:20522231 SwissProt P50569.1 462 RecName: Full=Steroidogenic factor 1; Short=SF-1; Short=STF-1; AltName: Full=Adrenal 4-binding protein; AltName: Full=Fushi tarazu factor homolog 1; AltName: Full=Nuclear receptor subfamily 5 group A member 1; AltName: Full=Steroid hormone receptor Ad4BP [Rattus norvegicus]