Gene/Proteome Database (LMPD)
LMPD ID
LMP001273
Gene ID
Species
Mus musculus (Mouse)
Gene Name
alkaline ceramidase 1
Gene Symbol
Synonyms
2310024P18Rik; AI662009; Alkcdase1; Asah3; Cer1
Alternate Names
alkaline ceramidase 1; maCER1; alkCDase 1; alkaline cdase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
Chromosome
17
Map Location
17 D|17
EC Number
3.5.1.23
Proteins
alkaline ceramidase 1 | |
---|---|
Refseq ID | NP_783858 |
Protein GI | 28376625 |
UniProt ID | Q8R4X1 |
mRNA ID | NM_175731 |
Length | 273 |
RefSeq Status | VALIDATED |
MHVPGTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFYGVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILWLLASGYSVWLPRCYFPKFVKGNRFYFSCLVTITTIISTFLTFVKPTVNAYALNSIAIHILYIVRTEYKKIRDDDLRHLIAVSVVLWAAALTSWISDRVLCSFWQRIHFYYLHSIWHVLISITFPYGIVTMALVDAKYEMPDKTLKVHYWPRDSWVIGLPYVEIQENDKNC |
Gene Information
Gene Ontology (GO Annotations)
GO ID | Source | Type | Description |
---|---|---|---|
GO:0005783 | IDA:MGI | C | endoplasmic reticulum |
GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
GO:0017040 | IDA:MGI | F | ceramidase activity |
GO:0071633 | IEA:Ensembl | F | dihydroceramidase activity |
GO:0071277 | IEA:Ensembl | P | cellular response to calcium ion |
GO:0046514 | IDA:MGI | P | ceramide catabolic process |
GO:0030216 | IEA:Ensembl | P | keratinocyte differentiation |
GO:0019216 | IDA:MGI | P | regulation of lipid metabolic process |
GO:0010446 | IEA:Ensembl | P | response to alkaline pH |
GO:0006665 | IDA:MGI | P | sphingolipid metabolic process |
GO:0046512 | IEA:Ensembl | P | sphingosine biosynthetic process |
KEGG Pathway Links
KEGG Pathway ID | Description |
---|---|
mmu00600 | Sphingolipid metabolism |
BIOCYC Pathway Links
BIOCYC Pathway ID | Description |
---|---|
PWY3DJ-11470 | sphingosine and sphingosine-1-phosphate metabolism |
REACTOME Pathway Links
REACTOME Pathway ID | Description |
---|---|
5893777 | Sphingolipid de novo biosynthesis |
Domain Information
InterPro Annotations
Accession | Description |
---|---|
IPR008901 | Ceramidase |
UniProt Annotations
Entry Information
Comments
Comment Type | Description |
---|---|
Biophysicochemical Properties | pH dependence: Optimum pH is 8.0. {ECO:0000269|PubMed:12783875}; |
Catalytic Activity | N-acylsphingosine + H(2)O = a carboxylate + sphingosine. |
Enzyme Regulation | Inhibited by sphingosine. Inhibited by Mn(2+), Zn(2+), and Cu(2+) in a dose-dependent manner. Slightly activated by Ca(2+) in a dose-dependent manner. {ECO:0000269|PubMed:12783875}. |
Function | Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. {ECO:0000269|PubMed:12783875}. |
Similarity | Belongs to the alkaline ceramidase family. {ECO:0000305}. |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:12783875}; Multi-pass membrane protein {ECO:0000269|PubMed:12783875}. |
Tissue Specificity | Highly expressed in skin. Weakly or not expressed in other tissues. {ECO:0000269|PubMed:12783875}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001273 (as displayed in Record Overview)
Protein GI | Database | Accession | Length | Protein Name |
---|---|---|---|---|
28376625 | RefSeq | NP_783858 | 273 | alkaline ceramidase 1 |
Identical Sequences to LMP001273 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:28376625 | DBBJ | BAC26186.1 | 273 | unnamed protein product [Mus musculus] |
GI:28376625 | DBBJ | BAC36029.1 | 273 | unnamed protein product [Mus musculus] |
GI:28376625 | GenBank | AAL83821.1 | 273 | alkaline ceramidase [Mus musculus] |
GI:28376625 | GenBank | AAI30255.1 | 273 | Alkaline ceramidase 1 [Mus musculus] |
GI:28376625 | GenBank | AGF22455.1 | 273 | Sequence 15 from patent US 8372595 |
GI:28376625 | SwissProt | Q8R4X1.1 | 273 | RecName: Full=Alkaline ceramidase 1; Short=AlkCDase 1; Short=Alkaline CDase 1; Short=maCER1; AltName: Full=Acylsphingosine deacylase 3; AltName: Full=N-acylsphingosine amidohydrolase 3 [Mus musculus] |
Related Sequences to LMP001273 proteins
Reference | Database | Accession | Length | Protein Name |
---|---|---|---|---|
GI:28376625 | GenBank | EDL38214.1 | 274 | N-acylsphingosine amidohydrolase (alkaline ceramidase) 3, partial [Mus musculus] |
GI:28376625 | GenBank | EDL83598.1 | 273 | similar to N-acylsphingosine amidohydrolase 3 [Rattus norvegicus] |
GI:28376625 | GenBank | EGV93739.1 | 264 | Alkaline ceramidase 1 [Cricetulus griseus] |
GI:28376625 | RefSeq | NP_001100345.1 | 273 | alkaline ceramidase 1 [Rattus norvegicus] |
GI:28376625 | RefSeq | XP_005371164.1 | 264 | PREDICTED: alkaline ceramidase 1 [Microtus ochrogaster] |
GI:28376625 | RefSeq | XP_006982337.1 | 273 | PREDICTED: alkaline ceramidase 1 [Peromyscus maniculatus bairdii] |