Gene/Proteome Database (LMPD)

LMPD ID
LMP001273
Gene ID
Species
Mus musculus (Mouse)
Gene Name
alkaline ceramidase 1
Gene Symbol
Synonyms
2310024P18Rik; AI662009; Alkcdase1; Asah3; Cer1
Alternate Names
alkaline ceramidase 1; maCER1; alkCDase 1; alkaline cdase 1; acylsphingosine deacylase 3; N-acylsphingosine amidohydrolase 3
Chromosome
17
Map Location
17 D|17
EC Number
3.5.1.23

Proteins

alkaline ceramidase 1
Refseq ID NP_783858
Protein GI 28376625
UniProt ID Q8R4X1
mRNA ID NM_175731
Length 273
RefSeq Status VALIDATED
MHVPGTRAKMSSIFAYQSSEVDWCESNFQHSELVAEFYNTFSNVFFLIFGPLMMFLMHPYAQKRTRCFYGVSVLFMLIGLFSMYFHMTLSFLGQLLDEISILWLLASGYSVWLPRCYFPKFVKGNRFYFSCLVTITTIISTFLTFVKPTVNAYALNSIAIHILYIVRTEYKKIRDDDLRHLIAVSVVLWAAALTSWISDRVLCSFWQRIHFYYLHSIWHVLISITFPYGIVTMALVDAKYEMPDKTLKVHYWPRDSWVIGLPYVEIQENDKNC

Gene Information

Entrez Gene ID
Gene Name
alkaline ceramidase 1
Gene Symbol
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0016021 IEA:UniProtKB-KW C integral component of membrane
GO:0017040 IDA:MGI F ceramidase activity
GO:0071633 IEA:Ensembl F dihydroceramidase activity
GO:0071277 IEA:Ensembl P cellular response to calcium ion
GO:0046514 IDA:MGI P ceramide catabolic process
GO:0030216 IEA:Ensembl P keratinocyte differentiation
GO:0019216 IDA:MGI P regulation of lipid metabolic process
GO:0010446 IEA:Ensembl P response to alkaline pH
GO:0006665 IDA:MGI P sphingolipid metabolic process
GO:0046512 IEA:Ensembl P sphingosine biosynthetic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00600 Sphingolipid metabolism

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY3DJ-11470 sphingosine and sphingosine-1-phosphate metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893777 Sphingolipid de novo biosynthesis

Domain Information

InterPro Annotations

Accession Description
IPR008901 Ceramidase

UniProt Annotations

Entry Information

Gene Name
alkaline ceramidase 1
Protein Entry
ACER1_MOUSE
UniProt ID
Species
Mouse

Comments

Comment Type Description
Biophysicochemical Properties pH dependence: Optimum pH is 8.0. {ECO:0000269|PubMed:12783875};
Catalytic Activity N-acylsphingosine + H(2)O = a carboxylate + sphingosine.
Enzyme Regulation Inhibited by sphingosine. Inhibited by Mn(2+), Zn(2+), and Cu(2+) in a dose-dependent manner. Slightly activated by Ca(2+) in a dose-dependent manner. {ECO:0000269|PubMed:12783875}.
Function Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo- phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids. {ECO:0000269|PubMed:12783875}.
Similarity Belongs to the alkaline ceramidase family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:12783875}; Multi-pass membrane protein {ECO:0000269|PubMed:12783875}.
Tissue Specificity Highly expressed in skin. Weakly or not expressed in other tissues. {ECO:0000269|PubMed:12783875}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001273 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
28376625 RefSeq NP_783858 273 alkaline ceramidase 1

Identical Sequences to LMP001273 proteins

Reference Database Accession Length Protein Name
GI:28376625 DBBJ BAC26186.1 273 unnamed protein product [Mus musculus]
GI:28376625 DBBJ BAC36029.1 273 unnamed protein product [Mus musculus]
GI:28376625 GenBank AAL83821.1 273 alkaline ceramidase [Mus musculus]
GI:28376625 GenBank AAI30255.1 273 Alkaline ceramidase 1 [Mus musculus]
GI:28376625 GenBank AGF22455.1 273 Sequence 15 from patent US 8372595
GI:28376625 SwissProt Q8R4X1.1 273 RecName: Full=Alkaline ceramidase 1; Short=AlkCDase 1; Short=Alkaline CDase 1; Short=maCER1; AltName: Full=Acylsphingosine deacylase 3; AltName: Full=N-acylsphingosine amidohydrolase 3 [Mus musculus]

Related Sequences to LMP001273 proteins

Reference Database Accession Length Protein Name
GI:28376625 GenBank EDL38214.1 274 N-acylsphingosine amidohydrolase (alkaline ceramidase) 3, partial [Mus musculus]
GI:28376625 GenBank EDL83598.1 273 similar to N-acylsphingosine amidohydrolase 3 [Rattus norvegicus]
GI:28376625 GenBank EGV93739.1 264 Alkaline ceramidase 1 [Cricetulus griseus]
GI:28376625 RefSeq NP_001100345.1 273 alkaline ceramidase 1 [Rattus norvegicus]
GI:28376625 RefSeq XP_005371164.1 264 PREDICTED: alkaline ceramidase 1 [Microtus ochrogaster]
GI:28376625 RefSeq XP_006982337.1 273 PREDICTED: alkaline ceramidase 1 [Peromyscus maniculatus bairdii]