Gene/Proteome Database (LMPD)

LMPD ID
LMP001277
Gene ID
5130
Species
Homo sapiens (Human)
Gene Name
phosphate cytidylyltransferase 1, choline, alpha
Gene Symbol
PCYT1A
Synonyms
CCTA; CT; CTA; CTPCT; PCYT1; SMDCRD
Alternate Names
choline-phosphate cytidylyltransferase A; CT A; CCT A; CCT-alpha; phosphorylcholine transferase A; CTP:phosphocholine cytidylyltransferase A
Chromosome
3
Map Location
3q29
EC Number
2.7.7.15

Proteins

choline-phosphate cytidylyltransferase A
Refseq ID NP_005008
Protein GI 31543385
UniProt ID P49585
mRNA ID NM_005017
Length 367
RefSeq Status PROVISIONAL
MDAQCSAKVNARKRRKEAPGPNGATEEDGVPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEASRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKEAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTRERSPSPSFRWPFSGKTSPPCSPANLSRHKAAAYDISEDEED

Gene Information

Entrez Gene ID
5130
Gene Name
phosphate cytidylyltransferase 1, choline, alpha
Gene Symbol
PCYT1A
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005789 ISS:UniProtKB C endoplasmic reticulum membrane
GO:0042587 ISS:UniProtKB C glycogen granule
GO:0004105 ISS:UniProtKB F choline-phosphate cytidylyltransferase activity
GO:0008289 IEA:Ensembl F lipid binding
GO:0006657 ISS:UniProtKB P CDP-choline pathway
GO:0046474 TAS:Reactome P glycerophospholipid biosynthetic process
GO:0006656 ISS:UniProtKB P phosphatidylcholine biosynthetic process
GO:0006644 TAS:Reactome P phospholipid metabolic process
GO:0044281 TAS:Reactome P small molecule metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa00564 Glycerophospholipid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
REACT_121238 Synthesis of PC

Domain Information

InterPro Annotations

Accession Description
IPR004821 Cytidyltransferase-like domain
IPR014729 Rossmann-like alpha/beta/alpha sandwich fold

UniProt Annotations

Entry Information

Gene Name
phosphate cytidylyltransferase 1, choline, alpha
Protein Entry
PCY1A_HUMAN
UniProt ID
P49585
Species
Human

Comments

Comment Type Description
Catalytic Activity CTP + phosphocholine = diphosphate + CDP- choline.
Disease Spondylometaphyseal dysplasia with cone-rod dystrophy (SMDCRD) [MIM
Enzyme Regulation By phosphorylation.
Function Controls phosphatidylcholine synthesis.
Pathway Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2.
Ptm Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation.
Ptm The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity).
Similarity Belongs to the cytidylyltransferase family.
Subcellular Location Cytoplasm, cytosol . Membrane {ECO
Subunit Homodimer.
Web Resource Name=SeattleSNPs; URL="http://pga.gs.washington.edu/data/pcyt1a/";

Identical and Related Proteins

Unique RefSeq proteins for LMP001277 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
31543385 RefSeq NP_005008 367 choline-phosphate cytidylyltransferase A

Identical Sequences to LMP001277 proteins

Reference Database Accession Length Protein Name
GI:31543385 GenBank ADT51032.1 367 Sequence 3049 from patent US 7842467
GI:31543385 GenBank ADT51034.1 367 Sequence 3051 from patent US 7842467
GI:31543385 GenBank ADT51035.1 367 Sequence 3052 from patent US 7842467
GI:31543385 GenBank AIC49350.1 367 PCYT1A, partial [synthetic construct]
GI:31543385 RefSeq XP_003806468.1 367 PREDICTED: choline-phosphate cytidylyltransferase A [Pan paniscus]
GI:31543385 RefSeq XP_008951642.1 367 PREDICTED: choline-phosphate cytidylyltransferase A [Pan paniscus]

Related Sequences to LMP001277 proteins

Reference Database Accession Length Protein Name
GI:31543385 EMBL CBX51349.1 367 unnamed protein product [Homo sapiens]
GI:31543385 GenBank AAA72127.1 367 CTP:phosphocholine cytidylyltransferase [Homo sapiens]
GI:31543385 GenBank ACM82126.1 369 Sequence 7624 from patent US 6812339
GI:31543385 GenBank ADT51033.1 367 Sequence 3050 from patent US 7842467
GI:31543385 PRF - 367 CTP/phosphocholine cytidylyltransferase [Homo sapiens]
GI:31543385 RefSeq XP_002814492.1 367 PREDICTED: choline-phosphate cytidylyltransferase A [Pongo abelii]