Gene/Proteome Database (LMPD)
LMPD ID
LMP001279
Gene ID
Species
Mus musculus (Mouse)
Gene Name
phosphate cytidylyltransferase 1, choline, alpha isoform
Gene Symbol
Synonyms
CTalpha; Cctalpha; Ctpct; Cttalpha
Alternate Names
choline-phosphate cytidylyltransferase A; CT A; CCT A; CCT-alpha; phosphorylcholine transferase A; CTP phosphocholine cytidylyl transferase; CTP:phosphocholine cytidylyltransferase A; CTP:phosphocholine cytidylyltransferase alpha
Chromosome
16
Map Location
16 B3|16 22.69 cM
EC Number
2.7.7.15
Proteins
| choline-phosphate cytidylyltransferase A | |
|---|---|
| Refseq ID | NP_001156631 |
| Protein GI | 253683456 |
| UniProt ID | P49586 |
| mRNA ID | NM_001163159 |
| Length | 367 |
| RefSeq Status | VALIDATED |
| MDAQSSAKVNSRKRRKEAPGPNGATEEDGIPSKVQRCAVGLRQPAPFSDEIEVDFSKPYVRVTMEEACRGTPCERPVRVYADGIFDLFHSGHARALMQAKNLFPNTYLIVGVCSDELTHNFKGFTVMNENERYDAVQHCRYVDEVVRNAPWTLTPEFLAEHRIDFVAHDDIPYSSAGSDDVYKHIKDAGMFAPTQRTEGISTSDIITRIVRDYDVYARRNLQRGYTAKELNVSFINEKKYHLQERVDKVKKKVKDVEEKSKEFVQKVEEKSIDLIQKWEEKSREFIGSFLEMFGPEGALKHMLKEGKGRMLQAISPKQSPSSSPTHERSPSPSFRWPFSGKTSPSSSPASLSRCRAVTCDISEDEED | |
| choline-phosphate cytidylyltransferase A | |
|---|---|
| Refseq ID | NP_034111 |
| Protein GI | 6753552 |
| UniProt ID | P49586 |
| mRNA ID | NM_009981 |
| Length | 367 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:253683456 (mRNA isoform) | |
| choline-phosphate cytidylyltransferase A | |
|---|---|
| Refseq ID | NP_001156632 |
| Protein GI | 253683458 |
| UniProt ID | P49586 |
| mRNA ID | NM_001163160 |
| Length | 367 |
| RefSeq Status | VALIDATED |
| Protein sequence is identical to GI:253683456 (mRNA isoform) | |
Gene Information
Entrez Gene ID
Gene Name
phosphate cytidylyltransferase 1, choline, alpha isoform
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005789 | IDA:MGI | C | endoplasmic reticulum membrane |
| GO:0042587 | IDA:MGI | C | glycogen granule |
| GO:0004105 | ISS:UniProtKB | F | choline-phosphate cytidylyltransferase activity |
| GO:0008289 | IEA:Ensembl | F | lipid binding |
| GO:0006657 | ISS:UniProtKB | P | CDP-choline pathway |
| GO:0006656 | IDA:MGI | P | phosphatidylcholine biosynthetic process |
KEGG Pathway Links
| KEGG Pathway ID | Description |
|---|---|
| mmu00564 | Glycerophospholipid metabolism |
Domain Information
UniProt Annotations
Entry Information
Gene Name
phosphate cytidylyltransferase 1, choline, alpha isoform
Protein Entry
PCY1A_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Catalytic Activity | CTP + phosphocholine = diphosphate + CDP- choline. |
| Enzyme Regulation | By phosphorylation. {ECO:0000250}. |
| Function | Controls phosphatidylcholine synthesis. |
| Pathway | Phospholipid metabolism; phosphatidylcholine biosynthesis; phosphatidylcholine from phosphocholine: step 1/2. |
| Ptm | Monoubiquitinated by the SCF(FBXL2) complex, leading to proteasomal degradation. |
| Ptm | The serine residues of the C-terminus are phosphorylated. The inactive soluble form is stabilized by phosphorylation, the active membrane bound form is promoted by anionic lipids or diacylglycerol, and is stabilized by dephosphorylation (By similarity). {ECO:0000250}. |
| Similarity | Belongs to the cytidylyltransferase family. {ECO:0000305}. |
| Subcellular Location | Cytoplasm, cytosol {ECO:0000250}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Note=It can interconvert between an inactive cytosolic form and an active membrane-bound form. {ECO:0000250}. |
| Subunit | Homodimer. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001279 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 253683456 | RefSeq | NP_001156631 | 367 | choline-phosphate cytidylyltransferase A |
Identical Sequences to LMP001279 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:253683456 | EMBL | CBF65898.1 | 367 | unnamed protein product [Mus musculus] |
| GI:253683456 | EMBL | CBU90769.1 | 367 | unnamed protein product [Mus musculus] |
| GI:253683456 | GenBank | EDK97791.1 | 367 | phosphate cytidylyltransferase 1, choline, alpha isoform, isoform CRA_a [Mus musculus] |
| GI:253683456 | GenBank | EDK97792.1 | 367 | phosphate cytidylyltransferase 1, choline, alpha isoform, isoform CRA_a [Mus musculus] |
| GI:253683456 | GenBank | AGX57861.1 | 367 | Sequence 16023 from patent US 8541208 |
| GI:253683456 | RefSeq | NP_001156632.1 | 367 | choline-phosphate cytidylyltransferase A [Mus musculus] |
Related Sequences to LMP001279 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:253683456 | GenBank | AAB59683.1 | 367 | CTP:phosphocholine cytidylyltransferase, partial [Rattus norvegicus] |
| GI:253683456 | GenBank | AAA53526.1 | 367 | CTP:phosphocholine cytidylyltransferase, partial [Mus musculus] |
| GI:253683456 | GenBank | EDM11414.1 | 367 | phosphate cytidylyltransferase 1, choline, alpha isoform, isoform CRA_a [Rattus norvegicus] |
| GI:253683456 | GenBank | EDM11415.1 | 367 | phosphate cytidylyltransferase 1, choline, alpha isoform, isoform CRA_a [Rattus norvegicus] |
| GI:253683456 | RefSeq | XP_008766916.1 | 367 | PREDICTED: choline-phosphate cytidylyltransferase A isoform X1 [Rattus norvegicus] |
| GI:253683456 | SwissProt | P19836.2 | 367 | RecName: Full=Choline-phosphate cytidylyltransferase A; AltName: Full=CCT-alpha; AltName: Full=CTP:phosphocholine cytidylyltransferase A; Short=CCT A; Short=CT A; AltName: Full=Phosphorylcholine transferase A [Rattus norvegicus] |