Gene/Proteome Database (LMPD)

LMPD ID
LMP001285
Gene ID
18607
Species
Mus musculus (Mouse)
Gene Name
3-phosphoinositide dependent protein kinase 1
Gene Symbol
Pdpk1
Synonyms
Pdk1
Chromosome
17
Map Location
17 A3.3|17

Proteins

3-phosphoinositide-dependent protein kinase 1 isoform A
Refseq ID NP_035192
Protein GI 124107594
UniProt ID Q9Z2A0
mRNA ID NM_011062
Length 559
RefSeq Status VALIDATED
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRSQTEPGSSPGIPSGVSRQGSTMDGTTAEARPSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQSNPDAAVQ
3-phosphoinositide-dependent protein kinase 1 isoform B
Refseq ID NP_001074242
Protein GI 124107598
UniProt ID Q3TRL2
mRNA ID NM_001080773
Length 522
RefSeq Status VALIDATED
MARTTSQLYDAVPIQSSVVLCSCPSPSMVRSQTEPGSSPGIPSGVSRQGSTMDGTTAEARPSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTM
3-phosphoinositide-dependent protein kinase 1 isoform C
Refseq ID NP_001273591
Protein GI 557786185
UniProt ID Q3UGN6
mRNA ID NM_001286662
Length 532
RefSeq Status VALIDATED
MVRSQTEPGSSPGIPSGVSRQGSTMDGTTAEARPSTNPLQQHPAQLPPQPRKKRPEDFKFGKILGEGSFSTVVLARELATSREYAIKILEKRHIIKENKVPYVTRERDVMSRLDHPFFVKLYFTFQDDEKLYFGLSYAKNGELLKYIRKIGSFDETCTRFYTAEIVSALEYLHGKGIIHRDLKPENILLNEDMHIQITDFGTAKVLSPESKQARANSFVGTAQYVSPELLTEKSACKSSDLWALGCIIYQLVAGLPPFRAGNEYLIFQKIIKLEYHFPEKFFPKARDLVEKLLVLDATKRLGCEEMEGYGPLKAHPFFETITWENLHQQTPPKLTAYLPAMSEDDEDCYGNYDNLLSQFGFMQVSSSSSSHSLSTVETSLPQRSGSNIEQYIHDLDTNSFELDLQFSEDEKRLLLEKQAGGNPWHQFVENNLILKMGPVDKRKGLFARRRQLLLTEGPHLYYVDPVNKVLKGEIPWSQELRPEAKNFKTFFVHTPNRTYYLMDPSGNAHKWCRKIQEVWRQQYQSNPDAAVQ

Gene Information

Entrez Gene ID
18607
Gene Name
3-phosphoinositide dependent protein kinase 1
Gene Symbol
Pdpk1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0042995 IEA:Ensembl C cell projection
GO:0005737 IDA:MGI C cytoplasm
GO:0016023 IDA:MGI C cytoplasmic membrane-bounded vesicle
GO:0005829 IEA:Ensembl C cytosol
GO:0005886 IEA:Ensembl C plasma membrane
GO:0004676 IDA:MGI F 3-phosphoinositide-dependent protein kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0016004 IEA:Ensembl F phospholipase activator activity
GO:0032148 IEA:Ensembl P activation of protein kinase B activity
GO:0019722 IEA:Ensembl P calcium-mediated signaling
GO:0016477 IEA:Ensembl P cell migration
GO:0071364 IEA:Ensembl P cellular response to epidermal growth factor stimulus
GO:0032869 IEA:Ensembl P cellular response to insulin stimulus
GO:0007173 IEA:Ensembl P epidermal growth factor receptor signaling pathway
GO:0097191 IEA:Ensembl P extrinsic apoptotic signaling pathway
GO:0048041 IEA:Ensembl P focal adhesion assembly
GO:0006972 IDA:MGI P hyperosmotic response
GO:0006469 IEA:Ensembl P negative regulation of protein kinase activity
GO:0030512 IEA:Ensembl P negative regulation of transforming growth factor beta receptor signaling pathway
GO:0018107 IEA:Ensembl P peptidyl-threonine phosphorylation
GO:0090004 IEA:Ensembl P positive regulation of establishment of protein localization to plasma membrane
GO:0010518 IEA:Ensembl P positive regulation of phospholipase activity
GO:0051281 IEA:Ensembl P positive regulation of release of sequestered calcium ion into cytosol
GO:0043122 IEA:Ensembl P regulation of I-kappaB kinase/NF-kappaB signaling
GO:0007165 TAS:MGI P signal transduction

Domain Information

InterPro Annotations

Accession Description
IPR011993 Pleckstrin homology-like domain
IPR000719 Protein kinase domain
IPR017441 Protein kinase, ATP binding site
IPR011009 Protein kinase-like domain
IPR008271 Serine/threonine-protein kinase, active site
IPR002290 Serine/threonine/dual specificity protein kinase, catalytic domain

UniProt Annotations

Entry Information

Gene Name
3-phosphoinositide dependent protein kinase 1
Protein Entry
PDPK1_MOUSE
UniProt ID
Q9Z2A0
Species
Mouse

Identical and Related Proteins

Unique RefSeq proteins for LMP001285 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
124107594 RefSeq NP_035192 559 3-phosphoinositide-dependent protein kinase 1 isoform A
124107598 RefSeq NP_001074242 522 3-phosphoinositide-dependent protein kinase 1 isoform B
557786185 RefSeq NP_001273591 532 3-phosphoinositide-dependent protein kinase 1 isoform C

Identical Sequences to LMP001285 proteins

Reference Database Accession Length Protein Name
GI:124107598 DBBJ BAE37017.1 522 unnamed protein product [Mus musculus]
GI:124107594 GenBank AAD38505.1 559 phosphoinositide-dependent protein kinase 1 [Mus musculus]
GI:124107594 GenBank ABK42305.1 559 Pdpk1 [synthetic construct]
GI:124107594 GenBank EDL22291.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:124107594 GenBank AAI46004.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:124107594 GenBank AAI46002.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:557786185 RefSeq XP_006523886.1 532 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 isoform X1 [Mus musculus]
GI:557786185 RefSeq XP_006523887.1 532 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 isoform X2 [Mus musculus]
GI:557786185 RefSeq XP_006523888.1 532 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 isoform X3 [Mus musculus]
GI:557786185 RefSeq XP_006523889.1 532 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 isoform X4 [Mus musculus]
GI:557786185 RefSeq XP_006523892.1 532 PREDICTED: 3-phosphoinositide-dependent protein kinase 1 isoform X7 [Mus musculus]
GI:124107594 SwissProt Q9Z2A0.2 559 RecName: Full=3-phosphoinositide-dependent protein kinase 1; Short=mPDK1 [Mus musculus]

Related Sequences to LMP001285 proteins

Reference Database Accession Length Protein Name
GI:124107594 DBBJ BAE27716.1 559 unnamed protein product [Mus musculus]
GI:124107594 DBBJ BAE28171.1 559 unnamed protein product [Mus musculus]
GI:124107594 GenBank AAC67544.1 559 phosphoinositide-dependent protein kinase PDK1 [Mus musculus]
GI:124107594 GenBank AAC96115.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:124107594 GenBank AAO17164.1 551 PDK1, partial [Mus musculus]
GI:557786185 GenBank AAO17164.1 551 PDK1, partial [Mus musculus]
GI:557786185 GenBank ABK42305.1 559 Pdpk1 [synthetic construct]
GI:124107598 GenBank ABK42305.1 559 Pdpk1 [synthetic construct]
GI:124107598 GenBank EDL22291.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:557786185 GenBank EDL22291.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:124107598 GenBank AAI46004.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:557786185 GenBank AAI46004.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:124107598 GenBank AAI46002.1 559 3-phosphoinositide dependent protein kinase-1 [Mus musculus]
GI:557786185 RefSeq NP_035192.2 559 3-phosphoinositide-dependent protein kinase 1 isoform A [Mus musculus]
GI:124107598 RefSeq NP_035192.2 559 3-phosphoinositide-dependent protein kinase 1 isoform A [Mus musculus]
GI:124107598 SwissProt Q9Z2A0.2 559 RecName: Full=3-phosphoinositide-dependent protein kinase 1; Short=mPDK1 [Mus musculus]
GI:557786185 SwissProt Q9Z2A0.2 559 RecName: Full=3-phosphoinositide-dependent protein kinase 1; Short=mPDK1 [Mus musculus]
GI:124107594 SwissProt O55173.2 559 RecName: Full=3-phosphoinositide-dependent protein kinase 1; AltName: Full=Protein kinase B kinase; Short=PkB kinase [Rattus norvegicus]