Gene/Proteome Database (LMPD)

LMPD ID
LMP001287
Gene ID
13106
Species
Mus musculus (Mouse)
Gene Name
cytochrome P450, family 2, subfamily e, polypeptide 1
Gene Symbol
Cyp2e1
Synonyms
Cyp2e
Alternate Names
cytochrome P450 2E1; CYPIIE1; cytochrome P450-J; cytochrome P450-ALC; 4-nitrophenol 2-hydroxylase; cytochrome P450, 2e1, ethanol inducible
Chromosome
7
Map Location
7 F5|7 85.94 cM
EC Number
1.14.13.-

Proteins

cytochrome P450 2E1
Refseq ID NP_067257
Protein GI 11276065
UniProt ID Q05421
mRNA ID NM_021282
Length 493
RefSeq Status PROVISIONAL
MAVLGITVALLVWIATLLLVSIWKQIYRSWNLPPGPFPIPFFGNIFQLDLKDIPKSLTKLAKRFGPVFTLHLGQRRIVVLHGYKAVKEVLLNHKNEFSGRGDIPVFQEYKNKGIIFNNGPTWKDVRRFSLSILRDWGMGKQGNEARIQREAHFLVEELKKTKGQPFDPTFLIGCAPCNVIADILFNKRFDYDDKKCLELMSLFNENFYLLSTPWIQAYNYFSDYLQYLPGSHRKVMKNVSEIRQYTLGKAKEHLKSLDINCPRDVTDCLLIEMEKEKHSQEPMYTMENISVTLADLFFAGTETTSTTLRYGLLILMKYPEIEEKLHEEIDRVIGPSRAPAVRDRMNMPYMDAVVHEIQRFINLVPSNLPHEATRDTVFRGYVIPKGTVVIPTLDSLLFDNYEFPDPETFKPEHFLNENGKFKYSDYFKAFSAGKRVCVGEGLARMELFLLLSAILQHFNLKSLVDPKDIDLSPVTIGFGSIPREFKLCVIPRS

Gene Information

Entrez Gene ID
13106
Gene Name
cytochrome P450, family 2, subfamily e, polypeptide 1
Gene Symbol
Cyp2e1
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0000139 IEA:Ensembl C Golgi membrane
GO:0005783 IDA:MGI C endoplasmic reticulum
GO:0031227 IEA:Ensembl C intrinsic component of endoplasmic reticulum membrane
GO:0005739 IEA:Ensembl C mitochondrion
GO:0020037 ISS:UniProtKB F heme binding
GO:0005506 IEA:InterPro F iron ion binding
GO:0004497 IDA:MGI F monooxygenase activity
GO:0016709 IEA:UniProtKB-EC F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen
GO:0016712 IEA:Ensembl F oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
GO:0017144 IEA:Ensembl P drug metabolic process
GO:0046483 IEA:Ensembl P heterocycle metabolic process
GO:0016098 IEA:Ensembl P monoterpenoid metabolic process
GO:0042493 IEA:Ensembl P response to drug
GO:0045471 IEA:Ensembl P response to ethanol
GO:0010243 IEA:Ensembl P response to organonitrogen compound
GO:0010193 IEA:Ensembl P response to ozone
GO:0008202 IEA:Ensembl P steroid metabolic process
GO:0006641 IEA:Ensembl P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu05204 Chemical carcinogenesis
mmu04932 Non-alcoholic fatty liver disease (NAFLD)

Domain Information

InterPro Annotations

Accession Description
IPR001128 Cytochrome P450
IPR002401 Cytochrome P450, E-class, group I
IPR008070 Cytochrome P450, E-class, group I, CYP2E-like
IPR017972 Cytochrome P450, conserved site

UniProt Annotations

Entry Information

Gene Name
cytochrome P450, family 2, subfamily e, polypeptide 1
Protein Entry
CP2E1_MOUSE
UniProt ID
Q05421
Species
Mouse

Comments

Comment Type Description
Catalytic Activity 4-nitrophenol + NADPH + O(2) = 4-nitrocatechol + NADP(+) + H(2)O.
Cofactor Name=heme; Xref=ChEBI:CHEBI:30413; Evidence={ECO:0000250};
Developmental Stage Detectable in the female liver on day 1 and reaches steady state levels on days 16-20.
Function Metabolizes several precarcinogens, drugs, and solvents to reactive metabolites. {ECO:0000250}.
Induction By ethanol and acetone in the liver and by testosterone in the kidney and adrenal tissues.
Similarity Belongs to the cytochrome P450 family. {ECO:0000305}.
Subcellular Location Endoplasmic reticulum membrane; Peripheral membrane protein. Microsome membrane; Peripheral membrane protein.
Tissue Specificity Highest level in the liver and to a lesser extent in the kidney, with a higher level in the male kidney than in the female.

Identical and Related Proteins

Unique RefSeq proteins for LMP001287 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
11276065 RefSeq NP_067257 493 cytochrome P450 2E1

Identical Sequences to LMP001287 proteins

Reference Database Accession Length Protein Name
GI:11276065 EMBL CAA44481.1 493 mouse Cyp2e1 [Mus musculus]
GI:11276065 GenBank AAA39879.1 493 cytochrome P-450 IIE1 [Mus musculus domesticus]
GI:11276065 GenBank AAH13451.1 493 Cytochrome P450, family 2, subfamily e, polypeptide 1 [Mus musculus]
GI:11276065 GenBank EDL17945.1 493 cytochrome P450, family 2, subfamily e, polypeptide 1, isoform CRA_e [Mus musculus]
GI:11276065 PRF - 493 cytochrome P450J [Mus musculus]
GI:11276065 SwissProt Q05421.1 493 RecName: Full=Cytochrome P450 2E1; AltName: Full=4-nitrophenol 2-hydroxylase; AltName: Full=CYPIIE1; AltName: Full=Cytochrome P450-ALC; AltName: Full=Cytochrome P450-J [Mus musculus]

Related Sequences to LMP001287 proteins

Reference Database Accession Length Protein Name
GI:11276065 GenBank AAA41033.1 493 cytochrome P450IIE1 [Rattus norvegicus]
GI:11276065 GenBank AAC15991.1 493 cytochrome P450 2E1 [Rattus norvegicus]
GI:11276065 GenBank AAH81774.1 493 Cytochrome P450, family 2, subfamily e, polypeptide 1 [Rattus norvegicus]
GI:11276065 GenBank EDM11924.1 493 cytochrome P450, family 2, subfamily e, polypeptide 1, isoform CRA_d [Rattus norvegicus]
GI:11276065 RefSeq XP_006230582.1 558 PREDICTED: cytochrome P450 2E1 isoform X1 [Rattus norvegicus]
GI:11276065 SwissProt P05182.4 493 RecName: Full=Cytochrome P450 2E1; AltName: Full=4-nitrophenol 2-hydroxylase; AltName: Full=CYPIIE1; AltName: Full=Cytochrome P450-J; AltName: Full=Cytochrome P450RLM6 [Rattus norvegicus]