Gene/Proteome Database (LMPD)
LMPD ID
LMP001290
Gene ID
Species
Mus musculus (Mouse)
Gene Name
gamma-glutamyltransferase 5
Gene Symbol
Synonyms
AI551243; GGL; GGT-REL; Ggtla1
Alternate Names
gamma-glutamyltransferase 5; GGT 5; glutathione hydrolase 5; leukotriene-C4 hydrolase; gamma-glutamyl leukotrienase; gamma-glutamyltranspeptidase 5; gamma-glutamyltransferase-like activity 1
Chromosome
10
Map Location
10 C1|10
EC Number
2.3.2.2
Proteins
| gamma-glutamyltransferase 5 | |
|---|---|
| Refseq ID | NP_035950 |
| Protein GI | 31542891 |
| UniProt ID | Q9Z2A9 |
| mRNA ID | NM_011820 |
| Length | 573 |
| RefSeq Status | PROVISIONAL |
| MAWGHRATVCLVLLGVGLGLVIVVLAAVLSPRQASCGPGAFTRAAVAADSKICSDIGRAILQQRGSPVDAAIAALVCTGVVNPQSMGLGGGVVFTIYNASTGKVEIINARETVPASYDQGLLNQCKNVLPLGTGAQWIGVPGELRGYAEAHRRHGRLPWAQLFQPTIALLREGFRVPFILSQFLNNSILRPHLSASTLRQLFFNGTETLRSQDPFPWPALANTLETVAKEGAEVLYTGRLGRMLVEDIAKQGSLLTVQDLAAFQPEVVEPLEMPLGNYTLYSPPPPAGGAILSFILNVLKGFNFSAETVARPGGEVNMYHHLVETLKFAVGQRWRLWDPSSHPGIQNISRDLLREDLAQRIRQQIDGRGDHHQLSHYNLTGVRGNRMGTSHVSVLGEDGSAVAATSTINTPFGAMVYSPRTGILLNNELLDLCWRHMPTSPITPPPVPGERPPSSMVPSILVNKGQGSKLVIGGAGGELIISAVAQTIMNKLWLGFDLTEAIASPILHVNSKGHVEYEPKFNQEVQKGLQDRGQIQSQSQRPVFLNAVQAVFQEGPCVYAASDLRKAGKASGY | |
Gene Information
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005886 | IDA:MGI | C | plasma membrane |
| GO:0003840 | IDA:MGI | F | gamma-glutamyltransferase activity |
| GO:0036374 | IEA:UniProtKB-EC | F | glutathione hydrolase activity |
| GO:0006750 | IEA:UniProtKB-KW | P | glutathione biosynthetic process |
| GO:0006954 | IMP:MGI | P | inflammatory response |
| GO:0019370 | IMP:MGI | P | leukotriene biosynthetic process |
KEGG Pathway Links
Domain Information
UniProt Annotations
Entry Information
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Z2A9-1; Sequence=Displayed; Name=2; IsoId=Q9Z2A9-2; Sequence=VSP_008147, VSP_008148; Note=Very low expression.; |
| Catalytic Activity | A (5-L-glutamyl)-peptide + an amino acid = a peptide + a 5-L-glutamyl amino acid. |
| Catalytic Activity | Glutathione + H(2)O = L-cysteinylglycine + L- glutamate. |
| Catalytic Activity | Leukotriene C(4) + H(2)O = leukotriene D(4) + L-glutamate. |
| Function | Cleaves the gamma-glutamyl peptide bond of glutathione conjugates, but maybe not glutathione itself. Converts leukotriene C4 (LTC4) to leukotriene D4 (LTD4). |
| Pathway | Lipid metabolism; leukotriene D4 biosynthesis. |
| Pathway | Sulfur metabolism; glutathione metabolism. |
| Ptm | Cleaved by autocatalysis into a large and a small subunit. {ECO:0000250}. |
| Similarity | Belongs to the gamma-glutamyltransferase family. {ECO:0000305}. |
| Subcellular Location | Membrane {ECO:0000250}; Single-pass type II membrane protein {ECO:0000250}. |
| Subunit | Heterodimer composed of the light and heavy chains. The active site is located in the light chain (By similarity). {ECO:0000250}. |
| Tissue Specificity | Very low level of expression. Detected in spleen lymphocytes, medullary and paracortical thymic lymphocytes, lung interstitial cells, bronchial epithelium, proximal tubules in kidney, crypt cells in small intestine, neurons in brain stem and cerebral cortex and in Purkinje cells. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001290 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31542891 | RefSeq | NP_035950 | 573 | gamma-glutamyltransferase 5 |
Identical Sequences to LMP001290 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31542891 | DBBJ | BAC34873.1 | 573 | unnamed protein product [Mus musculus] |
| GI:31542891 | DBBJ | BAE41720.1 | 573 | unnamed protein product [Mus musculus] |
| GI:31542891 | GenBank | AAI13776.1 | 573 | Gamma-glutamyltransferase 5 [Mus musculus] |
| GI:31542891 | GenBank | EDL31901.1 | 573 | gamma-glutamyltransferase-like activity 1, isoform CRA_d [Mus musculus] |
| GI:31542891 | SwissProt | Q9Z2A9.2 | 573 | RecName: Full=Gamma-glutamyltransferase 5; Short=GGT 5; AltName: Full=Gamma-glutamyl leukotrienase; Short=GGL; AltName: Full=Gamma-glutamyltransferase-like activity 1; AltName: Full=Gamma-glutamyltranspeptidase 5; AltName: Full=Glutathione hydrolase 5; AltName: Full=Leukotriene-C4 hydrolase; Contains: RecName: Full=Gamma-glutamyltransferase 5 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 5 light chain; Flags: Precursor [Mus musculus] |
Related Sequences to LMP001290 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31542891 | GenBank | AAC23546.1 | 572 | gamma glutamyl transpeptidase-related enzyme [Rattus norvegicus] |
| GI:31542891 | GenBank | AAC71001.1 | 573 | gamma-glutamyl leukotrienase [Mus musculus] |
| GI:31542891 | GenBank | AAH87018.1 | 572 | Gamma-glutamyltransferase 5 [Rattus norvegicus] |
| GI:31542891 | RefSeq | NP_062108.2 | 572 | gamma-glutamyltransferase 5 [Rattus norvegicus] |
| GI:31542891 | RefSeq | XP_007619957.1 | 570 | PREDICTED: gamma-glutamyltransferase 5 [Cricetulus griseus] |
| GI:31542891 | SwissProt | Q9QWE9.1 | 572 | RecName: Full=Gamma-glutamyltransferase 5; Short=GGT 5; AltName: Full=Gamma-glutamyl leukotrienase; Short=GGL; AltName: Full=Gamma-glutamyl transpeptidase-related enzyme; Short=GGT-rel; AltName: Full=Gamma-glutamyltransferase-like activity 1; AltName: Full=Gamma-glutamyltranspeptidase 5; AltName: Full=Glutathione hydrolase 5; AltName: Full=Leukotriene-C4 hydrolase; Contains: RecName: Full=Gamma-glutamyltransferase 5 heavy chain; Contains: RecName: Full=Gamma-glutamyltransferase 5 light chain; Flags: Precursor [Rattus norvegicus] |