Gene/Proteome Database (LMPD)

LMPD ID
LMP001294
Gene ID
8513
Species
Homo sapiens (Human)
Gene Name
lipase, gastric
Gene Symbol
LIPF
Synonyms
GL; HGL; HLAL
Alternate Names
gastric triacylglycerol lipase; gastric lipase
Chromosome
10
Map Location
10q23.31
EC Number
3.1.1.3
Summary
This gene encodes gastric lipase, an enzyme involved in the digestion of dietary triglycerides in the gastrointestinal tract, and responsible for 30% of fat digestion processes occurring in human. It is secreted by gastric chief cells in the fundic mucosa of the stomach, and it hydrolyzes the ester bonds of triglycerides under acidic pH conditions. The gene is a member of a conserved gene family of lipases that play distinct roles in neutral lipid metabolism. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]
Orthologs
View orthologs and multiple alignments for LIPF

Proteins

gastric triacylglycerol lipase isoform 1 precursor
Refseq ID NP_001185758
Protein GI 311771508
UniProt ID P07098
mRNA ID NM_001198829
Length 365
RefSeq Status REVIEWED
MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTDAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK
gastric triacylglycerol lipase isoform 2 precursor
Refseq ID NP_004181
Protein GI 4758676
UniProt ID P07098
mRNA ID NM_004190
Length 398
RefSeq Status REVIEWED
MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK
sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2045 peptide sequence: MWLLLTMASLISVLGTTHG mat_peptide: 20..365 product: gastric triacylglycerol lipase isoform 3 calculated_mol_wt: 39666 peptide sequence: LFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTDAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2771 peptide sequence: MFSNANSRSKMWLLLTMASLISVLG sig_peptide: 1..25 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2771 peptide sequence: MFSNANSRSKMWLLLTMASLISVLG sig_peptide: 1..19 inference: COORDINATES: ab initio prediction:SignalP:4.0 calculated_mol_wt: 2045 peptide sequence: MWLLLTMASLISVLGTTHG mat_peptide: 20..398 product: gastric triacylglycerol lipase isoform 2 calculated_mol_wt: 43211 peptide sequence: LFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTGQRPVVFLQHGLLASATNWISNLPNNSLAFILADAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK
gastric triacylglycerol lipase isoform 3 precursor
Refseq ID NP_001185757
Protein GI 311771508
UniProt ID P07098
mRNA ID NM_001198828
Length 365
RefSeq Status REVIEWED
MWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTDAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK
gastric triacylglycerol lipase isoform 4 precursor
Refseq ID NP_001185759
Protein GI 311771512
UniProt ID P07098
mRNA ID NM_001198830
Length 375
RefSeq Status REVIEWED
MFSNANSRSKMWLLLTMASLISVLGTTHGLFGKLHPGSPEVTMNISQMITYWGYPNEEYEVVTEDGYILEVNRIPYGKKNSGNTDAGYDVWLGNSRGNTWARRNLYYSPDSVEFWAFSFDEMAKYDLPATIDFIVKKTGQKQLHYVGHSQGTTIGFIAFSTNPSLAKRIKTFYALAPVATVKYTKSLINKLRFVPQSLFKFIFGDKIFYPHNFFDQFLATEVCSREMLNLLCSNALFIICGFDSKNFNTSRLDVYLSHNPAGTSVQNMFHWTQAVKSGKFQAYDWGSPVQNRMHYDQSQPPYYNVTAMNVPIAVWNGGKDLLADPQDVGLLLPKLPNLIYHKEIPFYNHLDFIWAMDAPQEVYNDIVSMISEDKK

Gene Information

Entrez Gene ID
8513
Gene Name
lipase, gastric
Gene Symbol
LIPF
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005576 IEA:UniProtKB-KW C extracellular region
GO:0005739 IEA:Ensembl C mitochondrion
GO:0008289 NAS:UniProtKB F lipid binding
GO:0016615 IEA:Ensembl F malate dehydrogenase activity
GO:0004806 TAS:UniProtKB F triglyceride lipase activity
GO:0016042 IEA:UniProtKB-KW P lipid catabolic process
GO:0006108 IEA:Ensembl P malate metabolic process
GO:0006641 NAS:UniProtKB P triglyceride metabolic process

KEGG Pathway Links

KEGG Pathway ID Description
hsa04975 Fat digestion and absorption
hsa00561 Glycerolipid metabolism

Domain Information

InterPro Annotations

Accession Description
IPR029058 Alpha/Beta hydrolase fold
IPR000073 Alpha/beta hydrolase fold-1
IPR025483 Lipase, eukaryotic
IPR006693 Partial AB-hydrolase lipase domain

UniProt Annotations

Entry Information

Gene Name
lipase, gastric
Protein Entry
LIPG_HUMAN
UniProt ID
P07098
Species
Human

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=P07098-1; Sequence=Displayed; Name=2; IsoId=P07098-2; Sequence=VSP_047296; Note=No experimental confirmation available.; Name=3; IsoId=P07098-3; Sequence=VSP_047295; Note=No experimental confirmation available.; Name=4; IsoId=P07098-4; Sequence=VSP_047295, VSP_047296; Note=No experimental confirmation available.;
Catalytic Activity Triacylglycerol + H(2)O = diacylglycerol + a carboxylate.
Sequence Caution Sequence=CAA29414.1; Type=Erroneous initiation; Evidence= ;
Similarity Belongs to the AB hydrolase superfamily. Lipase family.
Subcellular Location Secreted.
Web Resource Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/lipf/";

Identical and Related Proteins

Unique RefSeq proteins for LMP001294 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
311771508 RefSeq NP_001185758 365 gastric triacylglycerol lipase isoform 1 precursor
4758676 RefSeq NP_004181 398 gastric triacylglycerol lipase isoform 2 precursor
311771508 RefSeq NP_001185757 365 gastric triacylglycerol lipase isoform 3 precursor
311771512 RefSeq NP_001185759 375 gastric triacylglycerol lipase isoform 4 precursor

Identical Sequences to LMP001294 proteins

Reference Database Accession Length Protein Name
GI:4758676 DBBJ BAG35782.1 398 unnamed protein product [Homo sapiens]
GI:311771508 DBBJ BAH13457.1 365 unnamed protein product [Homo sapiens]
GI:311771508 DBBJ BAH13457.1 365 unnamed protein product [Homo sapiens]
GI:311771512 EMBL CAH56244.1 375 hypothetical protein [Homo sapiens]
GI:4758676 GenBank ABW60422.1 398 Sequence 65 from patent US 7276593
GI:4758676 GenBank ACW02568.1 398 Sequence 445 from patent US 7547766
GI:4758676 GenBank AEN51656.1 398 Sequence 445 from patent US 8003334
GI:4758676 GenBank AGN09442.1 398 Sequence 17 from patent US 8445250
GI:4758676 GenBank AHE02390.1 398 Sequence 61327 from patent US 8586006

Related Sequences to LMP001294 proteins

Reference Database Accession Length Protein Name
GI:311771512 DBBJ BAH13457.1 365 unnamed protein product [Homo sapiens]
GI:311771512 DBBJ BAH13459.1 408 unnamed protein product [Homo sapiens]
GI:4758676 DBBJ BAH13459.1 408 unnamed protein product [Homo sapiens]
GI:311771508 EMBL CAH56244.1 375 hypothetical protein [Homo sapiens]
GI:311771508 EMBL CAH56244.1 375 hypothetical protein [Homo sapiens]
GI:4758676 GenBank AAI12273.1 398 Lipase, gastric [Homo sapiens]
GI:4758676 GenBank AAI13712.1 398 Lipase, gastric [Homo sapiens]
GI:4758676 GenBank ADR83149.1 398 lipase, gastric, partial [synthetic construct]
GI:4758676 GenBank AIC55420.1 398 LIPF, partial [synthetic construct]
GI:311771512 RefSeq XP_001139318.1 375 PREDICTED: gastric triacylglycerol lipase isoform X3 [Pan troglodytes]
GI:311771508 RefSeq XP_001139318.1 375 PREDICTED: gastric triacylglycerol lipase isoform X3 [Pan troglodytes]
GI:311771508 RefSeq XP_001139318.1 375 PREDICTED: gastric triacylglycerol lipase isoform X3 [Pan troglodytes]
GI:311771512 RefSeq NP_001185757.1 365 gastric triacylglycerol lipase isoform 3 precursor [Homo sapiens]
GI:4758676 RefSeq NP_001185758.1 408 gastric triacylglycerol lipase isoform 1 precursor [Homo sapiens]
GI:311771512 RefSeq NP_001185758.1 408 gastric triacylglycerol lipase isoform 1 precursor [Homo sapiens]
GI:311771508 RefSeq NP_001185759.1 375 gastric triacylglycerol lipase isoform 4 precursor [Homo sapiens]
GI:311771508 RefSeq NP_001185759.1 375 gastric triacylglycerol lipase isoform 4 precursor [Homo sapiens]
GI:311771508 RefSeq XP_003312759.1 365 PREDICTED: gastric triacylglycerol lipase isoform X4 [Pan troglodytes]
GI:311771508 RefSeq XP_003312759.1 365 PREDICTED: gastric triacylglycerol lipase isoform X4 [Pan troglodytes]
GI:311771508 RefSeq XP_003810554.1 365 PREDICTED: gastric triacylglycerol lipase isoform X4 [Pan paniscus]
GI:311771508 RefSeq XP_003810554.1 365 PREDICTED: gastric triacylglycerol lipase isoform X4 [Pan paniscus]
GI:311771508 RefSeq XP_003810555.1 375 PREDICTED: gastric triacylglycerol lipase isoform X3 [Pan paniscus]
GI:311771512 RefSeq XP_003810555.1 375 PREDICTED: gastric triacylglycerol lipase isoform X3 [Pan paniscus]
GI:311771508 RefSeq XP_003810555.1 375 PREDICTED: gastric triacylglycerol lipase isoform X3 [Pan paniscus]