Gene/Proteome Database (LMPD)
LMPD ID
LMP001298
Gene ID
Species
Homo sapiens (Human)
Gene Name
neutral sphingomyelinase (N-SMase) activation associated factor
Gene Symbol
Synonyms
FAN
Alternate Names
protein FAN; factor associated with N-SMase activation; factor associated with neutral sphingomyelinase activation
Chromosome
8
Map Location
8q12-q13
Summary
This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jan 2009]
Orthologs
Proteins
| protein FAN isoform 1 | |
|---|---|
| Refseq ID | NP_003571 |
| Protein GI | 31543297 |
| UniProt ID | Q92636 |
| mRNA ID | NM_003580 |
| Length | 917 |
| RefSeq Status | REVIEWED |
| MAFIRKKQQEQQLQLYSKERFSLLLLNLEEYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLRDCIKIGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY | |
| protein FAN isoform 2 | |
|---|---|
| Refseq ID | NP_001138244 |
| Protein GI | 221625547 |
| UniProt ID | Q92636 |
| mRNA ID | NM_001144772 |
| Length | 948 |
| RefSeq Status | REVIEWED |
| MTGQARFHRGAEACRAIRQCRSRRPRAAHPEGRAGSGRGSRHASPGVRRGGFSLLLLNLEEYYFEQHRANHILHKGSHHERKIRGSLKICSKSVIFEPDSISQPIIKIPLRDCIKIGKHGENGANRHFTKAKSGGISLIFSQVYFIKEHNVVAPYKIERGKMEYVFELDVPGKVEDVVETLLQLHRASCLDKLGDQTAMITAILQSRLARTSFDKNRFQNISEKLHMECKAEMVTPLVTNPGHVCITDTNLYFQPLNGYPKPVVQITLQDVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTAESYMLQWQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSSSELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPKFMYGSHYSSPGYVLFYLVRIAPEYMLCLQNGRFDNADRMFNSIAETWKNCLDGATDFKELIPEFYGDDVSFLVNSLKLDLGKRQGGQMVDDVELPPWASSPEDFLQKSKDALESNYVSEHLHEWIDLIFGYKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRRITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTGITVSRNGSSVFTTSQDSTLKMFSKESKMLQRSISFSNMALSSCLLLPGDATVITSSWDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKRHHFDLLAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIVCDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCFVWDGNSVLSGSQSGELLVWDLLGAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQIIFWKLQY | |
Gene Information
Entrez Gene ID
Gene Name
neutral sphingomyelinase (N-SMase) activation associated factor
Gene Symbol
Species
Homo sapiens
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005737 | TAS:ProtInc | C | cytoplasm |
| GO:0005057 | TAS:ProtInc | F | receptor signaling protein activity |
| GO:0016230 | IEA:Ensembl | F | sphingomyelin phosphodiesterase activator activity |
| GO:0006672 | TAS:ProtInc | P | ceramide metabolic process |
| GO:0035556 | TAS:GOC | P | intracellular signal transduction |
| GO:0043065 | IEA:Ensembl | P | positive regulation of apoptotic process |
| GO:0007165 | TAS:ProtInc | P | signal transduction |
Domain Information
UniProt Annotations
Entry Information
Gene Name
neutral sphingomyelinase (N-SMase) activation associated factor
Protein Entry
FAN_HUMAN
UniProt ID
Species
Human
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q92636-1; Sequence=Displayed; Name=2; IsoId=Q92636-2; Sequence=VSP_042036; Note=No experimental confirmation available.; |
| Function | Couples the p55 TNF-receptor (TNF-R55 / TNFR1) to neutral sphingomyelinase (N-SMASE). Specifically binds to the N- smase activation domain of TNF-R55. May regulate ceramide production by N-SMASE. |
| Interaction | P60709:ACTB; NbExp=2; IntAct=EBI-2947053, EBI-353944; O95166:GABARAP; NbExp=2; IntAct=EBI-2947053, EBI-712001; Q9H0R8:GABARAPL1; NbExp=6; IntAct=EBI-2947053, EBI-746969; P50552:VASP; NbExp=2; IntAct=EBI-2947053, EBI-748201; |
| Similarity | Contains 1 BEACH domain. {ECO |
| Similarity | Contains 1 GRAM domain. |
| Similarity | Contains 6 WD repeats. {ECO |
| Tissue Specificity | Ubiquitous. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001298 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 31543297 | RefSeq | NP_003571 | 917 | protein FAN isoform 1 |
| 221625547 | RefSeq | NP_001138244 | 948 | protein FAN isoform 2 |
Identical Sequences to LMP001298 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31543297 | GenBank | AAH41124.1 | 917 | Neutral sphingomyelinase (N-SMase) activation associated factor [Homo sapiens] |
| GI:31543297 | GenBank | EAW86817.1 | 917 | neutral sphingomyelinase (N-SMase) activation associated factor [Homo sapiens] |
| GI:31543297 | GenBank | AHD78578.1 | 917 | Sequence 26576 from patent US 8586006 |
| GI:31543297 | GenBank | AIC55409.1 | 917 | NSMAF, partial [synthetic construct] |
| GI:31543297 | SwissProt | Q92636.2 | 917 | RecName: Full=Protein FAN; AltName: Full=Factor associated with neutral sphingomyelinase activation; Short=Factor associated with N-SMase activation [Homo sapiens] |
Related Sequences to LMP001298 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:31543297 | DBBJ | BAF85368.1 | 917 | unnamed protein product [Homo sapiens] |
| GI:31543297 | DBBJ | BAG36703.1 | 917 | unnamed protein product [Homo sapiens] |
| GI:221625547 | DBBJ | BAG57371.1 | 948 | unnamed protein product [Homo sapiens] |
| GI:31543297 | EMBL | CAA65405.1 | 917 | FAN protein [Homo sapiens] |
| GI:31543297 | GenBank | AAV21104.1 | 917 | Sequence 1364 from patent US 6753314 |
| GI:221625547 | GenBank | JAA24931.1 | 951 | neutral sphingomyelinase (N-SMase) activation associated factor [Pan troglodytes] |
| GI:31543297 | GenBank | JAA34691.1 | 920 | neutral sphingomyelinase (N-SMase) activation associated factor [Pan troglodytes] |
| GI:221625547 | RefSeq | XP_003256059.1 | 952 | PREDICTED: LOW QUALITY PROTEIN: protein FAN [Nomascus leucogenys] |
| GI:221625547 | RefSeq | XP_008973712.1 | 951 | PREDICTED: protein FAN isoform X1 [Pan paniscus] |
| GI:221625547 | RefSeq | XP_009453701.1 | 951 | PREDICTED: protein FAN isoform X1 [Pan troglodytes] |
| GI:31543297 | RefSeq | XP_009453702.1 | 920 | PREDICTED: protein FAN isoform X2 [Pan troglodytes] |
| GI:221625547 | RefSeq | XP_010385096.1 | 955 | PREDICTED: LOW QUALITY PROTEIN: protein FAN [Rhinopithecus roxellana] |