Gene/Proteome Database (LMPD)
LMPD ID
LMP001327
Gene ID
Species
Mus musculus (Mouse)
Gene Name
inositol 1,4,5-trisphosphate receptor 1
Gene Symbol
Synonyms
D6Pas2; ENSMUSG00000072853; Gm10429; IP3R1; InsP3R; Ip3r; Itpr-1; P400; Pcp-1; Pcp1; opt
Alternate Names
inositol 1,4,5-trisphosphate receptor type 1; IP3R 1; insP3R1; IP3 receptor; opisthotonus; InsP3R type I; protein PCD-6; InsP>3<R type I; type 1 InsP3 receptor; Purkinje cell protein 1; inositol 1,4,5-triphosphate receptor 1; type 1 inositol 1,4,5-trisphosphate receptor; inositol 1,4,5-trisphosphate-binding protein P400
Chromosome
6
Map Location
6 E1-E2|6 49.74 cM
Proteins
| inositol 1,4,5-trisphosphate receptor type 1 | |
|---|---|
| Refseq ID | NP_034715 |
| Protein GI | 291327470 |
| UniProt ID | P11881 |
| mRNA ID | NM_010585 |
| Length | 2749 |
| RefSeq Status | VALIDATED |
| MSDKMSSFLHIGDICSLYAEGSTNGFISTLGLVDDRCVVQPEAGDLNNPPKKFRDCLFKLCPMNRYSAQKQFWKAAKPGANSTTDAVLLNKLHHAADLEKKQNETENRKLLGTVIQYGNVIQLLHLKSNKYLTVNKRLPALLEKNAMRVTLDEAGNEGSWFYIQPFYKLRSIGDSVVIGDKVVLNPVNAGQPLHASSHQLVDNPGCNEVNSVNCNTSWKIVLFMKWSDNKDDILKGGDVVRLFHAEQEKFLTCDEHRKKQHVFLRTTGRQSATSATSSKALWEVEVVQHDPCRGGAGYWNSLFRFKHLATGHYLAAEVDPDFEEECLEFQPSVDPDQDASRSRLRNAQEKMVYSLVSVPEGNDISSIFELDPTTLRGGDSLVPRNSYVRLRHLCTNTWVHSTNIPIDKEEEKPVMLKIGTSPLKEDKEAFAIVPVSPAEVRDLDFANDASKVLGSIAGKLEKGTITQNERRSVTKLLEDLVYFVTGGTNSGQDVLEVVFSKPNRERQKLMREQNILKQIFKLLQAPFTDCGDGPMLRLEELGDQRHAPFRHICRLCYRVLRHSQQDYRKNQEYIAKQFGFMQKQIGYDVLAEDTITALLHNNRKLLEKHITAAEIDTFVSLVRKNREPRFLDYLSDLCVSMNKSIPVTQELICKAVLNPTNADILIETKLVLSRFEFEGVSTGENALEAGEDEEEVWLFWRDSNKEIRSKSVRELAQDAKEGQKEDRDILSYYRYQLNLFARMCLDRQYLAINEISGQLDVDLILRCMSDENLPYDLRASFCRLMLHMHVDRDPQEQVTPVKYARLWSEIPSEIAIDDYDSSGTSKDEIKERFAQTMEFVEEYLRDVVCQRFPFSDKEKNKLTFEVVNLARNLIYFGFYNFSDLLRLTKILLAILDCVHVTTIFPISKMTKGEENKGSNVMRSIHGVGELMTQVVLRGGGFLPMTPMAAAPEGNVKQAEPEKEDIMVMDTKLKIIEILQFILNVRLDYRISCLLCIFKREFDESNSQSSETSSGNSSQEGPSNVPGALDFEHIEEQAEGIFGGSEENTPLDLDDHGGRTFLRVLLHLTMHDYPPLVSGALQLLFRHFSQRQEVLQAFKQVQLLVTSQDVDNYKQIKQDLDQLRSIVEKSELWVYKGQGPDEPMDGASGENEHKKTEEGTSKPLKHESTSSYNYRVVKEILIRLSKLCVQESASVRKSRKQQQRLLRNMGAHAVVLELLQIPYEKAEDTKMQEIMRLAHEFLQNFCAGNQQNQALLHKHINLFLNPGILEAVTMQHIFMNNFQLCSEINERVVQHFVHCIETHGRNVQYIKFLQTIVKAEGKFIKKCQDMVMAELVNSGEDVLVFYNDRASFQTLIQMMRSERDRMDENSPLMYHIHLVELLAVCTEGKNVYTEIKCNSLLPLDDIVRVVTHEDCIPEVKIAYINFLNHCYVDTEVEMKEIYTSNHMWKLFENFLVDICRACNNTSDRKHADSILEKYVTEIVMSIVTTFFSSPFSDQSTTLQTRQPVFVQLLQGVFRVYHCNWLMPSQKASVESCIRVLSDVAKSRAIAIPVDLDSQVNNLFLKSHNIVQKTALNWRLSARNAARRDSVLAASRDYRNIIERLQDIVSALEDRLRPLVQAELSVLVDVLHRPELLFPENTDARRKCESGGFICKLIKHTKQLLEENEEKLCIKVLQTLREMMTKDRGYGEKQISIDESENAELPQAPEAENSTEQELEPSPPLRQLEDHKRGEALRQILVNRYYGNIRPSGRRESLTSFGNGPLSPGGPSKPGGGGGGPGSSSTSRGEMSLAEVQCHLDKEGASNLVIDLIMNASSDRVFHESILLAIALLEGGNTTIQHSFFCRLTEDKKSEKFFKVFYDRMKVAQQEIKATVTVNTSDLGNKKKDDEVDRDAPSRKKAKEPTTQITEEVRDQLLEASAATRKAFTTFRREADPDDHYQSGEGTQATTDKAKDDLEMSAVITIMQPILRFLQLLCENHNRDLQNFLRCQNNKTNYNLVCETLQFLDCICGSTTGGLGLLGLYINEKNVALINQTLESLTEYCQGPCHENQNCIATHESNGIDIITALILNDINPLGKKRMDLVLELKNNASKLLLAIMESRHDSENAERILYNMRPKELVEVIKKAYMQGEVEFEDGENGEDGAASPRNVGHNIYILAHQLARHNKELQTMLKPGGQVDGDEALEFYAKHTAQIEIVRLDRTMEQIVFPVPSICEFLTKESKLRIYYTTERDEQGSKINDFFLRSEDLFNEMNWQKKLRAQPVLYWCARNMSFWSSISFNLAVLMNLLVAFFYPFKGVRGGTLEPHWSGLLWTAMLISLAIVIALPKPHGIRALIASTILRLIFSVGLQPTLFLLGAFNVCNKIIFLMSFVGNCGTFTRGYRAMVLDVEFLYHLLYLLICAMGLFVHEFFYSLLLFDLVYREETLLNVIKSVTRNGRSIILTAVLALILVYLFSIVGYLFFKDDFILEVDRLPNETAVPETGESLANDFLYSDVCRVETGENCTSPAPKEELLPAEETEQDKEHTCETLLMCIVTVLSHGLRSGGGVGDVLRKPSKEEPLFAARVIYDLLFFFMVIIIVLNLIFGVIIDTFADLRSEKQKKEEILKTTCFICGLERDKFDNKTVTFEEHIKEEHNMWHYLCFIVLVKVKDSTEYTGPESYVAEMIRERNLDWFPRMRAMSLVSSDSEGEQNELRNLQEKLESTMKLVTNLSGQLSELKDQMTEQRKQKQRIGLLGHPPHMNVNPQQPA | |
Gene Information
Entrez Gene ID
Gene Name
inositol 1,4,5-trisphosphate receptor 1
Gene Symbol
Species
Mus musculus
Gene Ontology (GO Annotations)
| GO ID | Source | Type | Description |
|---|---|---|---|
| GO:0005955 | IDA:MGI | C | calcineurin complex |
| GO:0005737 | IDA:MGI | C | cytoplasm |
| GO:0005783 | TAS:MGI | C | endoplasmic reticulum |
| GO:0005789 | IDA:MGI | C | endoplasmic reticulum membrane |
| GO:0016021 | IEA:UniProtKB-KW | C | integral component of membrane |
| GO:0005635 | IDA:MGI | C | nuclear envelope |
| GO:0005637 | IDA:MGI | C | nuclear inner membrane |
| GO:0005730 | IDA:MGI | C | nucleolus |
| GO:0031088 | IEA:Ensembl | C | platelet dense granule membrane |
| GO:0031094 | IEA:Ensembl | C | platelet dense tubular network |
| GO:0014069 | IDA:MGI | C | postsynaptic density |
| GO:0043234 | IPI:MGI | C | protein complex |
| GO:0016529 | IDA:MGI | C | sarcoplasmic reticulum |
| GO:0005220 | IDA:UniProtKB | F | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity |
| GO:0005218 | IDA:UniProtKB | F | intracellular ligand-gated calcium channel activity |
| GO:0035091 | IDA:UniProtKB | F | phosphatidylinositol binding |
| GO:0006816 | IDA:MGI | P | calcium ion transport |
| GO:0032469 | IGI:MGI | P | endoplasmic reticulum calcium ion homeostasis |
| GO:0048016 | IDA:GOC | P | inositol phosphate-mediated signaling |
| GO:0070059 | IMP:UniProtKB | P | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress |
| GO:0009791 | IMP:MGI | P | post-embryonic development |
| GO:0051209 | IMP:UniProtKB | P | release of sequestered calcium ion into cytosol |
| GO:0001666 | IDA:BHF-UCL | P | response to hypoxia |
| GO:0050882 | IMP:MGI | P | voluntary musculoskeletal movement |
KEGG Pathway Links
Domain Information
InterPro Annotations
| Accession | Description |
|---|---|
| IPR000493 | Inositol 1,4,5-trisphosphate-binding protein receptor |
| IPR014821 | Inositol 1,4,5-trisphosphate/ryanodine receptor |
| IPR005821 | Ion transport domain |
| IPR016093 | MIR_motif |
| IPR000699 | RIH (RyR and IP3R Homology) domain |
| IPR013662 | RyR/IP3R Homology associated domain |
| IPR015925 | Ryanodine receptor-related |
UniProt Annotations
Entry Information
Gene Name
inositol 1,4,5-trisphosphate receptor 1
Protein Entry
ITPR1_MOUSE
UniProt ID
Species
Mouse
Comments
| Comment Type | Description |
|---|---|
| Alternative Products | Event=Alternative splicing; Named isoforms=8; Comment=There is a combination of two alternatively spliced domains at site SI and site SII (A, B and C). Experimental confirmation may be lacking for some isoforms.; Name=1; Synonyms=SISIIABC; IsoId=P11881-1; Sequence=Displayed; Name=2; Synonyms=SI-SIIABC; IsoId=P11881-2; Sequence=VSP_002691; Name=3; Synonyms=SISIIAC; IsoId=P11881-3; Sequence=VSP_002693; Name=4; Synonyms=SI-SIIAC; IsoId=P11881-4; Sequence=VSP_002691, VSP_002693; Name=5; Synonyms=SISIIA; IsoId=P11881-5; Sequence=VSP_002693, VSP_002694; Name=6; Synonyms=SI-SIIA; IsoId=P11881-6; Sequence=VSP_002691, VSP_002693, VSP_002694; Name=7; Synonyms=SISII; IsoId=P11881-7; Sequence=VSP_002692, VSP_002693, VSP_002694; Name=8; Synonyms=SI-SII; IsoId=P11881-8; Sequence=VSP_002691, VSP_002692, VSP_002693, VSP_002694; |
| Domain | The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand- binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. |
| Function | Intracellular channel that mediates calcium release from the endoplasmic reticulum following stimulation by inositol 1,4,5- trisphosphate. Plays a role in ER stress-induced apoptosis. Cytoplasmic calcium released from the ER triggers apoptosis by the activation of CaM kinase II, eventually leading to the activation of downstream apoptosis pathways. {ECO:0000269|PubMed:19752026, ECO:0000269|PubMed:20813840, ECO:0000269|PubMed:2554142}. |
| Interaction | Q9D1Q6:Erp44; NbExp=5; IntAct=EBI-541478, EBI-541567; |
| Miscellaneous | Calcium appears to inhibit ligand binding to the receptor, most probably by interacting with a distinct calcium- binding protein which then inhibits the receptor. |
| Ptm | Phosphorylated by cAMP kinase. Phosphorylation prevents the ligand-induced opening of the calcium channels. {ECO:0000269|PubMed:18630941}. |
| Ptm | Phosphorylated on tyrosine residues. {ECO:0000250}. |
| Ptm | Ubiquitination at multiple lysines targets ITPR1 for proteasomal degradation. Approximately 40% of the ITPR1-associated ubiquitin is monoubiquitin, and polyubiquitins are both 'Lys-48'- and 'Lys-63'-linked (By similarity). {ECO:0000250}. |
| Sequence Caution | Sequence=AAA88319.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH03271.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; |
| Similarity | Belongs to the InsP3 receptor family. {ECO:0000305}. |
| Similarity | Contains 5 MIR domains. {ECO:0000255|PROSITE- ProRule:PRU00131}. |
| Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:2554142}; Multi-pass membrane protein {ECO:0000269|PubMed:2554142}. |
| Subunit | Homotetramer. Interacts with TRPC4. The PPXXF motif binds HOM1, HOM2 and HOM3. Interacts with RYR1, RYR2, ITPR1, SHANK1 and SHANK3. Part of cGMP kinase signaling complex at least composed of ACTA2/alpha-actin, CNN1/calponin H1, PLN/phospholamban, PRKG1 and ITPR1 (By similarity). Interacts with ERP44 in a pH-, redox state- and calcium-dependent manner which results in the inhibition the calcium channel activity. The strength of this interaction inversely correlates with calcium concentration. Interacts with AHCYL1 and MRVI1. Interacts with CABP1 (By similarity). Interacts with TESPA1. {ECO:0000250, ECO:0000269|PubMed:12442173, ECO:0000269|PubMed:12525476, ECO:0000269|PubMed:15652484, ECO:0000269|PubMed:16527252, ECO:0000269|PubMed:16990611, ECO:0000269|PubMed:23650607}. |
Identical and Related Proteins
Unique RefSeq proteins for LMP001327 (as displayed in Record Overview)
| Protein GI | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| 291327470 | RefSeq | NP_034715 | 2749 | inositol 1,4,5-trisphosphate receptor type 1 |
Identical Sequences to LMP001327 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:291327470 | SwissProt | P11881.2 | 2749 | RecName: Full=Inositol 1,4,5-trisphosphate receptor type 1; AltName: Full=IP3 receptor isoform 1; Short=IP3R 1; Short=InsP3R1; AltName: Full=Inositol 1,4,5-trisphosphate-binding protein P400; AltName: Full=Protein PCD-6; AltName: Full=Purkinje cell protein 1; AltName: Full=Type 1 inositol 1,4,5-trisphosphate receptor; Short=Type 1 InsP3 receptor [Mus musculus] |
Related Sequences to LMP001327 proteins
| Reference | Database | Accession | Length | Protein Name |
|---|---|---|---|---|
| GI:291327470 | EMBL | CAA33433.1 | 2749 | unnamed protein product [Mus musculus] |
| GI:291327470 | GenBank | AAN94183.1 | 2749 | Sequence 4 from patent US 6465211 |
| GI:291327470 | GenBank | ABH73376.1 | 2749 | Sequence 4 from patent US 7041440 |
| GI:291327470 | GenBank | EDK99409.1 | 2751 | inositol 1,4,5-triphosphate receptor 1, isoform CRA_b [Mus musculus] |
| GI:291327470 | GenBank | AAI72648.1 | 2749 | Inositol 1,4,5-triphosphate receptor 1 [synthetic construct] |
| GI:291327470 | PRF | - | 2749 | inositol trisphosphate binding protein P400 [Mus musculus] |