Gene/Proteome Database (LMPD)

LMPD ID
LMP001331
Gene ID
18705
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Gene Symbol
Pik3c2g
Synonyms
C80387; PI3K-C2-gamma
Alternate Names
phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; ptdIns-3-kinase C2 subunit gamma
Chromosome
6
Map Location
6 G2|6 69.7 cM
EC Number
2.7.1.154

Proteins

phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 1
Refseq ID NP_997566
Protein GI 46810282
UniProt ID O70167
mRNA ID NM_207683
Length 1506
RefSeq Status VALIDATED
MAYSWQTEPNRTEPQEDGSDTQQFHHTNQHLSSRQVRLGFDQLVEEINNKTPLSESEKEEDTYFVPDAPNLGSKWPSIYETHPRYFSEFTSQSPDSSQLRFGKLSAIGFNPAVLPTHQLIHEGASWRNPSGKYHGIEYPRFDALPPSSTGQGECNPQGQSGTKHHNYCGEHEGNLPHHHSSYSIDSIPNREKRRSGDVNLVEPSLEFSKDSFLPRTSENVSVESTEPIGCPIEIVEVPQGSNKNLASFCNKVKKIRESYHASDINSNSGKIWAITTAYPSRLFADTKFRVKISIDNSAQLLLLMPHANYLVKDLIAEILLLCANEPLSPKEYLLSVCGSEEFLQMDHSLGSHKIFQKNKSVIQLHLQKNRDTPGKLSRKSEDDHSPFHLNQLLEFTHIWKISRQCLSTVMKKYNLHVEHLLKPQKDMEEKHLSSMVSGNQHTSQPHVNNVLEEVKNICSVLGCIETKQVSDAVKELNLILQRPSQNFHQNSETSKKGFIERVTAELSRSIYQLIDVYCSSFCTDFQPVHTPGGVSHVHAGLQSHLSFTVCSLHNVPETWAHSYKAFSFSCWLTYAGKKLCQVKSCRPLPVTKSFSLLVNWNEIINFPLEIKSLPRESMLVIKLFGIDSATHSTNLLAWTCLPLFPRQESVLGSRLFSVTLQSEPPIEMIAPGVWDGSQPSPLTLQIDFPDAGWEYLKPESEENRTDHEEPPRECLKHIAKLSQKKSPLLLSEEKRRYLWFYRLYCNNENSSLPLVLGSAPGWDEETVSEMHAILRRWTFSHPWEALGLLTSRFPDQDIREVAVQQLDTLLTDELLDCLPQLVQAVKFEWNLESPLVELLPRRPLQSIRVAHCLYWLLRDAQGEAYFKSWYQELLAALQFCAGEALNEELSKEQKLVKLLGDIGEKVKSASDPQRKDVLKKEIGSLEEFFKDIKTCHLPLNPALCIKGIDRDACSYFTSNASPLKITFINANPMGKNISVIFKAGDDLRQDMLALQIIQVMDNAWLQEGLDMQMITYGCLSTGRAQGFIEMVPDAVTLAKIHLHSGLIGPLKENTIKKWFSQHNHLKEDYEKALRNFFYSCAGWCVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGKNIQHFQDFVELCCRAYNIVRKHSQLILSLLEMMLHAGLPELRGIEDLKYVHNNLRPQDTDLEATSHFTKKIKESLECFPVKLNNLIHTLAQMPALSLAKPAPQTLLQESCILNKTRTIQRVTILGFSKTHSNLYLMEVTCSDNRRSLTKKSFEQFYRLHSQMQKQFSSLALPEFPHWWHLPFTDSDHKRIRDLSHYVEQVLRGSYEVANSDCVLSFFLSEHIQPTLEDSPFVDPGENSLDKSPKVQLLMTYEDSRLTILVKHLKNIHLPDGSVPSAHVEIYLLPHPSEVRRKKTKCVPKCTDPTYNEIVVYDEVLGLQGHVLMLIVKSKTVFVGAVNIQLCSVPLNEEKWYPLGNSII

Gene Information

Entrez Gene ID
18705
Gene Name
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Gene Symbol
Pik3c2g
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005942 IBA:RefGenome C phosphatidylinositol 3-kinase complex
GO:0005886 IBA:RefGenome C plasma membrane
GO:0016303 IBA:RefGenome F 1-phosphatidylinositol-3-kinase activity
GO:0035005 IBA:RefGenome F 1-phosphatidylinositol-4-phosphate 3-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035091 IEA:InterPro F phosphatidylinositol binding
GO:0006935 IMP:UniProtKB P chemotaxis
GO:0036092 IBA:GOC P phosphatidylinositol-3-phosphate biosynthetic process
GO:0048015 IEA:InterPro P phosphatidylinositol-mediated signaling

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR000008 C2 domain
IPR000403 Phosphatidylinositol 3-/4-kinase, catalytic domain
IPR000341 Phosphatidylinositol 3-kinase Ras-binding (PI3K RBD) domain
IPR002420 Phosphatidylinositol 3-kinase, C2 domain
IPR018936 Phosphatidylinositol 3/4-kinase, conserved site
IPR015433 Phosphatidylinositol Kinase
IPR001263 Phosphoinositide 3-kinase, accessory (PIK) domain
IPR001683 Phox homologous domain
IPR011009 Protein kinase-like domain
IPR029071 Ubiquitin-related domain

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide
Protein Entry
P3C2G_MOUSE
UniProt ID
O70167
Species
Mouse

Comments

Comment Type Description
Alternative Products Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O70167-1; Sequence=Displayed; Name=2; IsoId=O70167-2; Sequence=VSP_004706, VSP_004707;
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 4- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,4-bisphosphate.
Function Generates phosphatidylinositol 3-phosphate (PtdIns3P) and phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) that act as second messengers. May play a role in SDF1A-stimulated chemotaxis. {ECO:0000269|PubMed:20536348, ECO:0000269|PubMed:9514948}.
Similarity Belongs to the PI3/PI4-kinase family. {ECO:0000255|PROSITE-ProRule:PRU00879, ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 C2 PI3K-type domain. {ECO:0000255|PROSITE- ProRule:PRU00880}.
Similarity Contains 1 C2 domain. {ECO:0000305}.
Similarity Contains 1 PI3K-RBD domain. {ECO:0000255|PROSITE- ProRule:PRU00879}.
Similarity Contains 1 PI3K/PI4K domain. {ECO:0000255|PROSITE- ProRule:PRU00269}.
Similarity Contains 1 PIK helical domain. {ECO:0000255|PROSITE- ProRule:PRU00878}.
Similarity Contains 1 PX (phox homology) domain. {ECO:0000255|PROSITE-ProRule:PRU00147}.
Subcellular Location Membrane {ECO:0000269|PubMed:9514948}; Peripheral membrane protein {ECO:0000269|PubMed:9514948}.
Tissue Specificity Expressed predominantly in liver. Also found in kidney, lung and lymphoid tissue. Down-regulated in BeF3 cells expressing the BCR-ABL oncogene p185. {ECO:0000269|PubMed:20536348, ECO:0000269|PubMed:9514948}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001331 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
46810282 RefSeq NP_997566 1506 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform 1

Identical Sequences to LMP001331 proteins

Reference Database Accession Length Protein Name
GI:46810282 DBBJ BAA25427.1 1506 Phosphoinositide 3-Kinase-C2gamma [Mus musculus]
GI:46810282 SwissProt O70167.1 1506 RecName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Short=PI3K-C2-gamma; Short=PtdIns-3-kinase C2 subunit gamma; AltName: Full=Phosphoinositide 3-kinase-C2-gamma [Mus musculus]

Related Sequences to LMP001331 proteins

Reference Database Accession Length Protein Name
GI:46810282 DBBJ BAA25634.1 1505 phosphoinositide 3-kinase [Rattus norvegicus]
GI:46810282 GenBank AAI50814.1 1506 Phosphatidylinositol 3-kinase, C2 domain containing, gamma polypeptide [Mus musculus]
GI:46810282 RefSeq NP_446375.1 1505 phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma [Rattus norvegicus]
GI:46810282 RefSeq XP_006976552.1 1506 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [Peromyscus maniculatus bairdii]
GI:46810282 RefSeq XP_008761570.1 1539 PREDICTED: phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma isoform X1 [Rattus norvegicus]
GI:46810282 SwissProt O70173.1 1505 RecName: Full=Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit gamma; Short=PI3K-C2-gamma; Short=PtdIns-3-kinase C2 subunit gamma; AltName: Full=Phosphoinositide 3-kinase-C2-gamma [Rattus norvegicus]