Gene/Proteome Database (LMPD)

LMPD ID
LMP001342
Gene ID
2181
Species
Homo sapiens (Human)
Gene Name
acyl-CoA synthetase long-chain family member 3
Gene Symbol
ACSL3
Synonyms
ACS3; FACL3; PRO2194
Chromosome
2
Map Location
2q34-q35
Summary
The protein encoded by this gene is an isozyme of the long-chain fatty-acid-coenzyme A ligase family. Although differing in substrate specificity, subcellular localization, and tissue distribution, all isozymes of this family convert free long-chain fatty acids into fatty acyl-CoA esters, and thereby play a key role in lipid biosynthesis and fatty acid degradation. This isozyme is highly expressed in brain, and preferentially utilizes myristate, arachidonate, and eicosapentaenoate as substrates. The amino acid sequence of this isozyme is 92% identical to that of rat homolog. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
Orthologs
View orthologs and multiple alignments for ACSL3

Proteins

long-chain-fatty-acid--CoA ligase 3
Refseq ID NP_004448
Protein GI 42794752
UniProt ID O95573
mRNA ID NM_004457
Length 720
RefSeq Status REVIEWED
MNNHVSSKPSTMKLKHTINPILLYFIHFLISLYTILTYIPFYFFSESRQEKSNRIKAKPVNSKPDSAYRSVNSLDGLASVLYPGCDTLDKVFTYAKNKFKNKRLLGTREVLNEEDEVQPNGKIFKKVILGQYNWLSYEDVFVRAFNFGNGLQMLGQKPKTNIAIFCETRAEWMIAAQACFMYNFQLVTLYATLGGPAIVHALNETEVTNIITSKELLQTKLKDIVSLVPRLRHIITVDGKPPTWSEFPKGIIVHTMAAVEALGAKASMENQPHSKPLPSDIAVIMYTSGSTGLPKGVMISHSNIIAGITGMAERIPELGEEDVYIGYLPLAHVLELSAELVCLSHGCRIGYSSPQTLADQSSKIKKGSKGDTSMLKPTLMAAVPEIMDRIYKNVMNKVSEMSSFQRNLFILAYNYKMEQISKGRNTPLCDSFVFRKVRSLLGGNIRLLLCGGAPLSATTQRFMNICFCCPVGQGYGLTESAGAGTISEVWDYNTGRVGAPLVCCEIKLKNWEEGGYFNTDKPHPRGEILIGGQSVTMGYYKNEAKTKADFFEDENGQRWLCTGDIGEFEPDGCLKIIDRKKDLVKLQAGEYVSLGKVEAALKNLPLVDNICAYANSYHSYVIGFVVPNQKELTELARKKGLKGTWEELCNSCEMENEVLKVLSEAAISASLEKFEIPVKIRLSPEPWTPETGLVTDAFKLKRKELKTHYQADIERMYGRK
long-chain-fatty-acid--CoA ligase 3
Refseq ID NP_976251
Protein GI 42794754
UniProt ID O95573
mRNA ID NM_203372
Length 720
RefSeq Status REVIEWED
Protein sequence is identical to GI:42794752 (mRNA isoform)

Gene Information

Entrez Gene ID
2181
Gene Name
acyl-CoA synthetase long-chain family member 3
Gene Symbol
ACSL3
Species
Homo sapiens

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0004467 IEA:Ensembl F long-chain fatty acid-CoA ligase activity
GO:0007420 IEA:Ensembl P brain development
GO:0006633 IEA:Ensembl P fatty acid biosynthetic process
GO:0007584 IEA:Ensembl P response to nutrient
GO:0014070 IEA:Ensembl P response to organic cyclic compound

KEGG Pathway Links

KEGG Pathway ID Description
hsa04920 Adipocytokine signaling pathway
hsa03320 PPAR signaling pathway
hsa04146 Peroxisome

BIOCYC Pathway Links

BIOCYC Pathway ID Description
PWY66-387 fatty acid alpha-oxidation II

Domain Information

InterPro Annotations

Accession Description
IPR020845 AMP-binding, conserved site
IPR000873 AMP-dependent synthetase/ligase

UniProt Annotations

Entry Information

Gene Name
acyl-CoA synthetase long-chain family member 3
Protein Entry
ACSL3_HUMAN
UniProt ID
O95573
Species
Human

Identical and Related Proteins

Unique RefSeq proteins for LMP001342 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
42794752 RefSeq NP_004448 720 long-chain-fatty-acid--CoA ligase 3

Identical Sequences to LMP001342 proteins

Reference Database Accession Length Protein Name
GI:42794752 GenBank AGX56964.1 720 Sequence 14247 from patent US 8541208
GI:42794752 GenBank AHD71217.1 720 Sequence 5911 from patent US 8586006
GI:42794752 GenBank AHD71218.1 720 Sequence 5912 from patent US 8586006
GI:42794752 RefSeq XP_008970284.1 720 PREDICTED: long-chain-fatty-acid--CoA ligase 3 [Pan paniscus]
GI:42794752 RefSeq XP_008970286.1 720 PREDICTED: long-chain-fatty-acid--CoA ligase 3 [Pan paniscus]
GI:42794752 RefSeq XP_009442680.1 720 PREDICTED: long-chain-fatty-acid--CoA ligase 3 [Pan troglodytes]

Related Sequences to LMP001342 proteins

Reference Database Accession Length Protein Name
GI:42794752 DBBJ BAA37142.1 720 Acyl-CoA synthetase 3 [Homo sapiens]
GI:42794752 DBBJ BAB72074.1 720 Acyl-CoA synthetase 3 [Homo sapiens]
GI:42794752 DBBJ BAB72139.1 720 Acyl-CoA synthetase 3 [Homo sapiens]
GI:42794752 DBBJ BAG37187.1 720 unnamed protein product [Homo sapiens]
GI:42794752 GenBank ACM81859.1 722 Sequence 7357 from patent US 6812339
GI:42794752 GenBank AEN34694.1 720 Sequence 622 from patent US 7998689