Gene/Proteome Database (LMPD)

LMPD ID
LMP001352
Gene ID
18718
Species
Mus musculus (Mouse)
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Gene Symbol
Pip4k2a
Synonyms
AW742916; Pip5k2a
Alternate Names
phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; PIP4KII-alpha; PI(5)P 4-kinase type II alpha; diphosphoinositide kinase 2-alpha; ptdIns(5)P-4-kinase isoform 2-alpha; 1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; 1-phosphatidylinositol-5-phosphate 4-kinase 2-alpha; phosphatidylinositol-5-phosphate 4-kinase type-2 alpha; phosphatidylinositol 5-phosphate 4-kinase type II alpha; phosphatidylinositol-4-phosphate 5-kinase, type II, alpha
Chromosome
2
Map Location
2 A3|2
EC Number
2.7.1.149

Proteins

phosphatidylinositol 5-phosphate 4-kinase type-2 alpha
Refseq ID NP_032871
Protein GI 125490368
UniProt ID O70172
mRNA ID NM_008845
Length 405
RefSeq Status VALIDATED
MATPGNLGSSVLASKTKTKKKHFVAQKVKLFRASDPLLSVLMWGVNHSINELSHVQIPVMLMPDDFKAYSKIKVDNHLFNKENMPSHFKFKEYCPMVFRNLRERFGIDDQDFQNSLTRSAPLPNDSQARSGARFHTSYDKRYVIKTITSEDVAEMHNILKKYHQYIVECHGVTLLPQFLGMYRLNVDGVEIYVIVTRNVFSHRLSVYRKYDLKGSTVAREASDKEKAKELPTLKDNDFINEGQKIYIDDNNKKIFLEKLKKDVEFLAQLKLMDYSLLVGIHDVERAEQEEVECEENDGEEEGESDSTHPIGTPPDSPGNTLNSSPPLAPGEFDPNIDVYAIKCHENAPRKEVYFMAIIDILTHYDAKKKAAHAAKTVKHGAGAEISTVNPEQYSKRFLDFIGHIL

Gene Information

Entrez Gene ID
18718
Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Gene Symbol
Pip4k2a
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0005634 IEA:UniProtKB-KW C nucleus
GO:0005886 IEA:UniProtKB-KW C plasma membrane
GO:0016309 IEA:UniProtKB-EC F 1-phosphatidylinositol-5-phosphate 4-kinase activity
GO:0005524 IEA:UniProtKB-KW F ATP binding
GO:0035855 IMP:UniProtKB P megakaryocyte development

KEGG Pathway Links

KEGG Pathway ID Description
mmu00562 Inositol phosphate metabolism
mmu04810 Regulation of actin cytoskeleton

Domain Information

InterPro Annotations

Accession Description
IPR023610 Phosphatidylinositol-4-phosphate 5-kinase
IPR027483 Phosphatidylinositol-4-phosphate 5-kinase, C-terminal
IPR027484 Phosphatidylinositol-4-phosphate 5-kinase, N-terminal domain
IPR002498 Phosphatidylinositol-4-phosphate 5-kinase, core
IPR016034 Phosphatidylinositol-4-phosphate 5-kinase, core, subgroup

UniProt Annotations

Entry Information

Gene Name
phosphatidylinositol-5-phosphate 4-kinase, type II, alpha
Protein Entry
PI42A_MOUSE
UniProt ID
O70172
Species
Mouse

Comments

Comment Type Description
Catalytic Activity ATP + 1-phosphatidyl-1D-myo-inositol 5- phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
Function Catalyzes the phosphorylation of phosphatidylinositol 5- phosphate (PtdIns5P) on the fourth hydroxyl of the myo-inositol ring, to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). May exert its function by regulating the levels of PtdIns5P, which functions in the cytosol by increasing AKT activity and in the nucleus signals through ING2. May regulate the pool of cytosolic PtdIns5P in response to the activation of tyrosine phosphorylation. May negatively regulate insulin- stimulated glucose uptake by lowering the levels of PtdIns5P (By similarity). May be involved in thrombopoiesis and the terminal maturation of megakaryocytes and regulation of their size. {ECO:0000250, ECO:0000269|PubMed:16434494}.
Similarity Contains 1 PIPK domain. {ECO:0000255|PROSITE- ProRule:PRU00781}.
Subcellular Location Nucleus {ECO:0000250}. Cytoplasm. Cell membrane. Note=Localization to the nucleus is modulated by the interaction with PIP4K2B (By similarity). Localized to the demarcation membrane system (DMS). May translocate from the cytosol to the cell membrane upon activation of tyrosine phosphorylation. May translocate from the inner to the outer segments of the rod photoreceptor cells in response to light. {ECO:0000250}.
Subunit Homodimer. Interacts with PIP4K2B. Interaction with PIP4K2B may modulate localization to the nucleus (By similarity). {ECO:0000250}.
Tissue Specificity Detected in rod photoreceptor cells. {ECO:0000269|PubMed:20204506}.

Identical and Related Proteins

Unique RefSeq proteins for LMP001352 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
125490368 RefSeq NP_032871 405 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha

Identical Sequences to LMP001352 proteins

Reference Database Accession Length Protein Name
GI:125490368 DBBJ BAA25676.1 405 type II phosphatidylinositolphosphate kinase-alpha [Mus musculus]
GI:125490368 DBBJ BAC30626.1 405 unnamed protein product [Mus musculus]
GI:125490368 GenBank AAH11097.1 405 Phosphatidylinositol-5-phosphate 4-kinase, type II, alpha [Mus musculus]
GI:125490368 GenBank ABK42323.1 405 phosphoinositide 5-phosphate 4-kinase type II-alpha [synthetic construct]
GI:125490368 GenBank EDL08108.1 405 phosphatidylinositol-4-phosphate 5-kinase, type II, alpha [Mus musculus]
GI:125490368 SwissProt O70172.1 405 RecName: Full=Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha; AltName: Full=1-phosphatidylinositol 5-phosphate 4-kinase 2-alpha; AltName: Full=Diphosphoinositide kinase 2-alpha; AltName: Full=Phosphatidylinositol 5-phosphate 4-kinase type II alpha; Short=PI(5)P 4-kinase type II alpha; Short=PIP4KII-alpha; AltName: Full=PtdIns(5)P-4-kinase isoform 2-alpha [Mus musculus]

Related Sequences to LMP001352 proteins

Reference Database Accession Length Protein Name
GI:125490368 DBBJ BAB28093.1 405 unnamed protein product [Mus musculus]
GI:125490368 GenBank JAB04499.1 406 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Callithrix jacchus]
GI:125490368 GenBank JAB15457.1 406 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Callithrix jacchus]
GI:125490368 GenBank JAB15458.1 406 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Callithrix jacchus]
GI:125490368 GenBank JAB33762.1 406 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Callithrix jacchus]
GI:125490368 GenBank JAB40404.1 406 phosphatidylinositol 5-phosphate 4-kinase type-2 alpha [Callithrix jacchus]