Gene/Proteome Database (LMPD)

LMPD ID
LMP001363
Gene ID
16993
Species
Mus musculus (Mouse)
Gene Name
leukotriene A4 hydrolase
Gene Symbol
Lta4h
Synonyms
-
Alternate Names
leukotriene A-4 hydrolase; LTA4 hydrodase; LTA-4 hydrolase
Chromosome
10
Map Location
10|10 C3
EC Number
3.3.2.6

Proteins

leukotriene A-4 hydrolase
Refseq ID NP_032543
Protein GI 116734870
UniProt ID P24527
mRNA ID NM_008517
Length 611
RefSeq Status VALIDATED
MPEVADTCSLASPASVCRTQHLHLRCSVDFARRTLTGTAALTVQSQEENLRSLTLDTKDLTIEKVVINGQEVKYTLGESQGYKGSPMEISLPIALSKNQEIVIEISFETSPKSSALQWLTPEQTSGKQHPYLFSQCQAIHCRAILPCQDTPSVKLTYTAEVSVPKELVALMSAIRDGEAPDPEDPSRKIYRFNQRVPIPCYLIALVVGALESRQIGPRTLVWSEKEQVEKSANEFSETESMLKIAEDLGGPYVWGQYDLLVLPPSFPYGGMENPCLTFVTPTLLAGDKSLSNVIAHEISHSWTGNLVTNKTWDHFWLNEGHTVYLERHICGRLFGEKFRHFHALGGWGELQNTIKTFGESHPFTKLVVDLKDVDPDVAYSSIPYEKGFALLFYLEQLLGGPEVFLGFLKAYVKKFSYQSVTTDDWKSFLYSHFKDKVDLLNQVDWNTWLYAPGLPPVKPNYDVTLTNACIALSQRWVTAKEEDLSSFSIADLKDLSSHQLNEFLAQVLQKAPLPLGHIKRMQEVYNFNAINNSEIRFRWLRLCIQSKWEEAIPLALKMATEQGRMKFTRPLFKDLAAFDKSHDQAVHTYQEHKASMHPVTAMLVGRDLKVD

Gene Information

Entrez Gene ID
16993
Gene Name
leukotriene A4 hydrolase
Gene Symbol
Lta4h
Species
Mus musculus

Gene Ontology (GO Annotations)

GO ID Source Type Description
GO:0005737 IEA:UniProtKB-KW C cytoplasm
GO:0070062 IEA:Ensembl C extracellular vesicular exosome
GO:0005634 IEA:Ensembl C nucleus
GO:0004177 ISS:UniProtKB F aminopeptidase activity
GO:0004301 ISS:UniProtKB F epoxide hydrolase activity
GO:0004463 ISS:UniProtKB F leukotriene-A4 hydrolase activity
GO:0008237 IEA:UniProtKB-KW F metallopeptidase activity
GO:0044822 IEA:Ensembl F poly(A) RNA binding
GO:0008270 ISS:UniProtKB F zinc ion binding
GO:0019370 ISS:UniProtKB P leukotriene biosynthetic process
GO:0043171 ISS:UniProtKB P peptide catabolic process

KEGG Pathway Links

KEGG Pathway ID Description
mmu00590 Arachidonic acid metabolism

REACTOME Pathway Links

REACTOME Pathway ID Description
5893593 Synthesis of Leukotrienes (LT) and Eoxins (EX)

Domain Information

InterPro Annotations

Accession Description
IPR016024 Armadillo-type fold
IPR012777 Leukotriene A4 hydrolase
IPR001930 Peptidase M1, alanine aminopeptidase/leukotriene A4 hydrolase
IPR015211 Peptidase M1, leukotriene A4 hydrolase, aminopeptidase C-terminal
IPR014782 Peptidase M1, membrane alanine aminopeptidase, N-terminal

UniProt Annotations

Entry Information

Gene Name
leukotriene A4 hydrolase
Protein Entry
LKHA4_MOUSE
UniProt ID
P24527
Species
Mouse

Comments

Comment Type Description
Biophysicochemical Properties Kinetic parameters: KM=5 uM for leukotriene A4 {ECO:0000269|PubMed:9287304}; Vmax=1030 nmol/min/mg enzyme for leukotriene A4 {ECO:0000269|PubMed:9287304};
Catalytic Activity (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa- 7,9,11,14-tetraenoate + H(2)O = (6Z,8E,10E,14Z)-(5S,12R)-5,12- dihydroxyicosa-6,8,10,14-tetraenoate. {ECO:0000269|PubMed:9287304}.
Cofactor Name=Zn(2+); Xref=ChEBI:CHEBI:29105; Note=Binds 1 zinc ion per subunit.;
Enzyme Regulation Inhibited by bestatin. Subject to suicide inhibition by leukotriene A4. {ECO:0000269|PubMed:9287304}.
Function Epoxide hydrolase that catalyzes the final step in the biosynthesis of the proinflammatory mediator leukotriene B4. Has also aminopeptidase activity. {ECO:0000269|PubMed:9287304}.
Pathway Lipid metabolism; leukotriene B4 biosynthesis.
Ptm Phosphorylation at Ser-416 inhibits enzymatic activity. {ECO:0000250}.
Similarity Belongs to the peptidase M1 family. {ECO:0000305}.
Subcellular Location Cytoplasm.

Identical and Related Proteins

Unique RefSeq proteins for LMP001363 (as displayed in Record Overview)

Protein GI Database Accession Length Protein Name
116734870 RefSeq NP_032543 611 leukotriene A-4 hydrolase

Identical Sequences to LMP001363 proteins

Reference Database Accession Length Protein Name
GI:116734870 DBBJ BAE22342.1 611 unnamed protein product [Mus musculus]
GI:116734870 SwissProt P24527.4 611 RecName: Full=Leukotriene A-4 hydrolase; Short=LTA-4 hydrolase; AltName: Full=Leukotriene A(4) hydrolase [Mus musculus]

Related Sequences to LMP001363 proteins

Reference Database Accession Length Protein Name
GI:116734870 GenBank AAB59675.1 611 leukotriene A-4 hydrolase [Mus musculus]
GI:116734870 GenBank AAH21417.1 611 Lta4h protein [Mus musculus]
GI:116734870 GenBank AAH99819.1 611 Leukotriene A4 hydrolase [Rattus norvegicus]
GI:116734870 RefSeq NP_001025202.1 611 leukotriene A-4 hydrolase [Rattus norvegicus]
GI:116734870 RefSeq XP_005068057.1 611 PREDICTED: leukotriene A-4 hydrolase isoform X1 [Mesocricetus auratus]
GI:116734870 RefSeq XP_007633300.1 611 PREDICTED: leukotriene A-4 hydrolase isoform X1 [Cricetulus griseus]